Results 151 to 160 of about 416,939 (310)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Leptomeningeal Carcinomatosis: A Diagnosis Challenge

open access: yesDiagnostic Cytopathology, EarlyView.
ABSTRACT Background Leptomeningeal carcinomatosis (LC) in patients with disseminated cancer has a grave prognosis and limited therapeutic options. Diagnosis is delayed due to low CSF volume and scant cellularity. This quality improvement project was undertaken to evaluate the diagnostic performance of CSF cytology in cases with radiologic evidence and ...
Makayla Hyde   +3 more
wiley   +1 more source

Intra‐Individual Variability of Blood and Urinary Steroid Markers and the Response to Codeine Intake in Healthy Men and Women

open access: yesDrug Testing and Analysis, EarlyView.
Short‐term codeine administration (1–3 days) caused individual alterations in Athlete Biological Passport steroid markers, including elevated urinary T/E ratios and decreased serum testosterone concentrations below individual thresholds, despite no significant changes at the group level.
Alexander Andersson   +5 more
wiley   +1 more source

Acute visual deterioration following endoscopic transsphenoidal resection of a pituitary adenoma secondary to a de novo cyst of normal pituitary origin: illustrative case. [PDF]

open access: yesJ Neurosurg Case Lessons
Gilbert M   +9 more
europepmc   +1 more source

Pituitary-induced lactation in mammary gland explants from the pregnant tammar (Macropus eugenii): A negative role for cyclic AMP

open access: yes, 1987
Pituitary-induced lactation in mammary gland explants from the pregnant tammar (Macropus eugenii): A negative role for cyclic ...
F Maher (13407936)   +1 more
core  

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

open access: yesDevelopmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr.   +5 more
wiley   +1 more source

Patient-reported outcomes in a pituitary tumor center of excellence (PTCOE)–aligned pituitary clinic compared with general endocrinology care

open access: yes
Purpose: Pituitary Tumor Centers of Excellence (PTCOE) were developed to standardize multidisciplinary care for pituitary disorders; however, their impact on patient-reported outcomes remains insufficiently characterized.
Yağcı, Ali Nail   +6 more
core   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han   +14 more
wiley   +1 more source

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