Results 51 to 60 of about 627,391 (362)

Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database

International Journal of Endocrinology, 2022
Objective. Adult growth hormone deficiency (AGHD) is an underdiagnosed disease associated with increased morbidity and mortality. Identifying people who may benefit from growth hormone (GH) therapy can be challenging, as many AGHD symptoms resemble those
Kevin C. J. Yuen, Anna Camilla Birkegard, Lewis S. Blevins, David R. Clemmons, Andrew R. Hoffman, Nicky Kelepouris, Janice M. Kerr, Jens M. Tarp, Maria Fleseriu   +8 more
doaj   +1 more source

Gene expression patterns in anterior pituitary associated with quantitative measure of oestrous behaviour in dairy cows [PDF]

, 2010
Intensive selection for high milk yield in dairy cows has raised production levels substantially but at the cost of reduced fertility, which manifests in different ways including reduced expression of oestrous behaviour.
Beerda, B., Frijters, A.C.J., Kommadath, A., Mulder, H.A., Pas, M.F.W., te, Smits, M.A., Veerkamp, R.F., Wit, A.A.C., de, Woelders, H.   +8 more
core   +2 more sources

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle [PDF]

, 2018
The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs).
Alvarado, M. Victoria, Andrade, André, Estêvão, M. Dulce, Felip, Alicia, Pinto, Patricia IS, Power, Deborah   +5 more
core   +1 more source

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

Advanced Materials, EarlyView.
A schematic illustration of how noble metals can be used to create nanoparticles (NPs) or nanoclusters (NCs). Noble metal NPs, due to their plasmonic properties, enable photothermal therapy and surface‐enhanced Raman scattering (SERS). In contrast, NCs, which lack a plasmonic resonance band, exhibit fluorescence, making them ideal for bioimaging ...
David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez   +3 more
wiley   +1 more source

Developmental and functional effects of steroid hormones on the neuroendocrine axis and spinal cord [PDF]

, 2016
This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual ...
Gonzalez Deniselle, Maria Claudia, Lara, H. E., Recabarren, S. E., Roselli, C. E., Zubeldia Brenner, Lautaro   +4 more
core   +2 more sources

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study

Human Genomics
Many researchers have explored the potential association between one neurosurgical disease and coronavirus disease 2019 (COVID-19), but few systematically analyzed the association and causality between COVID-19 and various neurosurgical diseases.
Lirui Dai, Liang Lyu, Peizhi Zhou, Shu Jiang   +3 more
doaj   +1 more source

Pituitary apoplexy

Indian Journal of Endocrinology and Metabolism, 2011
Pituitary apoplexy is rare endocrine emergency which can occur due to infarction or haemorrhage of pituitary gland. This disorder most often involves a pituitary adenoma. Occasionally it may be the first manifestation of an underlying adenoma. There is conflicting data regarding which type of pituitary adenoma is prone for apoplexy. Some studies showed
Salam Ranabir, Manash P Baruah
openaire   +3 more sources

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion

Advanced Science, EarlyView.
Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen, Shujun Jiang, Haolu Wang, Mengzhen Si, Haixia Wu, Xinyi Liang, Shenmeng Yao, Yanliang Zhang, Xiaodong Wen, Jie Yang   +9 more
wiley   +1 more source