Results 51 to 60 of about 574,474 (315)

Temozolomide and Capecitabine Treatment for an Aggressive Somatotroph Pituitary Tumor: A Case Report and Literature Review

Frontiers in Oncology, 2022
Aggressive somatotroph pituitary tumor that causes acromegaly is extremely rare and resists conventional treatments such as multiple surgeries, radiotherapies, and various types of somatostatin analogs. Here, we propose a novel treatment option for these
Atsushi Ishida, Hiroki Shichi, Hidenori Fukuoka, Hideki Shiramizu, Naoko Inoshita, Shozo Yamada   +5 more
doaj   +1 more source

Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling

Journal of neuroendocrinology, 2018
Reproduction and fertility are regulated via hormones of the hypothalamic‐pituitary‐gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex ...
A. Acevedo-Rodriguez, A. Kauffman, Brian D. Cherrington, C. S. Borges, T. Roepke, M. Laconi, M. Laconi   +6 more
semanticscholar   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

The STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease

Journal of Translational Medicine
Background Cushing’s disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol.
Fang Liu, Yanting Liu, Tao Zhang, Ning Huang, Desheng Chen, Xiaobin Wang, Jiangong Ma, Li Xue, Shaojian Lin, Zhe Bao Wu   +9 more
doaj   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma

Scientific Reports, 2017
Lactate dehydrogenase A (LDHA) has been reported to be involved in the initiation and progression of tumors. However, the potential role of LDHA in pituitary adenoma (PA) remains unknown.
Jiayin An, Yin Zhang, Jiaojiang He, Zhenle Zang, Zheng Zhou, Xiangdong Pei, Xin Zheng, Weihua Zhang, Hui Yang, Song Li   +9 more
doaj   +1 more source

Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement

Pituitary, 2017
IntroductionWith the goal of generate uniform criteria among centers dealing with pituitary tumors and to enhance patient care, the Pituitary Society decided to generate criteria for developing Pituitary Tumors Centers of Excellence (PTCOE).MethodsTo ...
F. Casanueva, A. Barkan, Michael Buchfelder, A. Klibanski, E. Laws, J. Loeffler, S. Melmed, Pietro Mortini, J. Wass, A. Giustina, Alin Abreu Julio Cristina Ariel L Albert Anat Ignacio M Lomba Abucham Alvarez-Escola Barkan Beckers Ben-Sh, A. Lomba, J. Abucham, C. Alvarez-Escola, A. Barkan, Albert Beckers, Anat Ben-Shlomo, I. Bernabéu, M. Bidlingmaier, N. Biermasz, B. Biller, C. Boguszewski, M. Bolanowski, J. Bollerslev, V. Bonert, M. Bronstein, O. Bruno, Michael Buchfelder, J. Carmichael, P. Caron, P. Chanson, F. Casanueva, Richard N. Clayton, A. Colao, F. Cordido, L. De Marinis, R. Fahlbusch, M. Fleseriu, A. Formenti, P. Freda, H. Fukuoka, E. Ghigo, A. Giustina, Y. Greenman, E. Grineva, Ashley Grossman, M. Gurnell, A. Heaney, A. Hoffman, I. Ilovayskaya, G. Johannsson, P. Kadıoğlu, N. Karavitaki, L. Katznelson, F. Keleştimur, D. Kelly, A. Klibanski, Ken K. Y. Ho, M. Kršek, A. Lacroix, E. Laws, Jay StevenLoeffler, M. Losa, Jens Otto Lunde Jørgensen, A. Luger, Susana M. Mallea-Gil, A. Mamelak, G. Mazziotti, A. McCormack, S. Melmed, M. Mercado, Pietro Mortini, S. Neggers, G. Ning, N. Oyesiku, V. Popović, M. Petakov, S. Petersenn, Michael Pfeifer, A. Picó, M. Domingo, G. Raverot, M. Reincke, M. Gadelha, R. Salvatori, S. Samson, A. Shimatsu, Ilan Shimon, Paul Stewart, C. Strasburger, B. Swearingen, P. Trainer, N. Tritos, S. Tsagarakis, A. J. van der Lely, L. Vilar, R. Villar-Taibo, J. Wass, M. Zatelli   +98 more
semanticscholar   +1 more source

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Fully endoscopic far-lateral supracerebellar infratentorial approach for trigeminal neuralgia: illustrative case reports

Chinese Neurosurgical Journal
Background Trigeminal neuralgia (TN) is a common cause of craniofacial pain. The retrosigmoid approach is usually used to treat TN, but no cases of endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA) were used to undergo operation ...
Hong Yao, Wenlei Yang, Hao Tang, Yijun Cheng, Shaojian Lin, Zhe Bao Wu   +5 more
doaj   +1 more source