Results 61 to 70 of about 365,982 (310)

Temozolomide and Capecitabine Treatment for an Aggressive Somatotroph Pituitary Tumor: A Case Report and Literature Review

Frontiers in Oncology, 2022
Aggressive somatotroph pituitary tumor that causes acromegaly is extremely rare and resists conventional treatments such as multiple surgeries, radiotherapies, and various types of somatostatin analogs. Here, we propose a novel treatment option for these
Atsushi Ishida, Hiroki Shichi, Hidenori Fukuoka, Hideki Shiramizu, Naoko Inoshita, Shozo Yamada   +5 more
doaj   +1 more source

Skull base repair following endonasal pituitary and skull base tumour resection: a systematic review. [PDF]

, 2021
PURPOSE: Postoperative cerebrospinal fluid rhinorrhoea (CSFR) remains a frequent complication of endonasal approaches to pituitary and skull base tumours. Watertight skull base reconstruction is important in preventing CSFR.
Ali, AMS, Dorward, NL, Muirhead, W., Ali, Ahmad MS, Koh, Chan Hee, Grieve, Joan, Zamanipoor Najafabadi, Amir H, Ali, A.M.S., Horsfall, H.L., Zamanipoor Najafabadi, AH, Marcus, H.J., Najafabadi, A.H.Z., Khan, D.Z., Furth, W.R. van, Koh, CH, Layard Horsfall, H, Santarius, T., Muirhead, William, Khan, DZ, Marcus, HJ, Santarius, Thomas, Santarius, T, Van Furth, WR, Khan, Danyal Z, Grieve, J., Koh, C.H., Muirhead, W, Marcus, Hani J, Dorward, Neil L, Grieve, J, Dorward, N.L., Layard Horsfall, Hugo, Van Furth, Wouter R   +32 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Lactate dehydrogenase A promotes the invasion and proliferation of pituitary adenoma

Scientific Reports, 2017
Lactate dehydrogenase A (LDHA) has been reported to be involved in the initiation and progression of tumors. However, the potential role of LDHA in pituitary adenoma (PA) remains unknown.
Jiayin An, Yin Zhang, Jiaojiang He, Zhenle Zang, Zheng Zhou, Xiangdong Pei, Xin Zheng, Weihua Zhang, Hui Yang, Song Li   +9 more
doaj   +1 more source

A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A novel hybrid transfer learning approach for brain tumor classification achieves 99.47% accuracy using magnetic resonance imaging (MRI) images. By combining image preprocessing, ensemble deep learning, and explainable artificial intelligence (XAI) techniques like gradient‐weighted class activation mapping and SHapley Additive exPlanations (SHAP), the ...
Sadia Islam Tonni, Md. Alif Sheakh, Mst. Sazia Tahosin, Md. Zahid Hasan, Taslima Ferdaus Shuva, Touhid Bhuiyan, Muhammad Ali Abdullah Almoyad, Nabil Anan Orka, Md. Tanvir Rahman, Risala Tasin Khan, M. Shamim Kaiser, Mohammad Ali Moni   +11 more
wiley   +1 more source

The STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease

Journal of Translational Medicine
Background Cushing’s disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol.
Fang Liu, Yanting Liu, Tao Zhang, Ning Huang, Desheng Chen, Xiaobin Wang, Jiangong Ma, Li Xue, Shaojian Lin, Zhe Bao Wu   +9 more
doaj   +1 more source

Perioperative management of endoscopic transsphenoidal pituitary surgery

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2020
The contemporary embrace of endoscopic technology in the approach to the anterior skull base has altered the perioperative landscape for patients requiring pituitary surgery.
Martin Hanson, Hao Li, Eliza Geer, Sasan Karimi, Viviane Tabar, Marc A. Cohen   +5 more
doaj   +1 more source

Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study

American Journal of Hematology, EarlyView.
ABSTRACT Diamond–Blackfan Anemia Syndrome (DBAS) is a rare congenital anemia often requiring chronic red blood cell transfusions from infancy. Without appropriate chelation, iron overload develops early and may be severe; however, no data are available on chelation in patients under 3 years of age.
Francesca Torchio, Baptiste Lecalvez, Emanuela Garelli, Coralie Mallebranche, Adriana Carando, Marie‐Pierre Castex, Nathalie Garnier, Marco Zecca, Nathalie Aladjidi, Elisa Bertoni, Arthur Sterin, Maria Licciardello, Anne Sirvent, Antonella Sau, Isabelle Marie, Benedicte Bruno, Lydie M. Da Costa, Franca Fagioli, Paola Quarello, Thierry Leblanc   +19 more
wiley   +1 more source

Fully endoscopic far-lateral supracerebellar infratentorial approach for trigeminal neuralgia: illustrative case reports

Chinese Neurosurgical Journal
Background Trigeminal neuralgia (TN) is a common cause of craniofacial pain. The retrosigmoid approach is usually used to treat TN, but no cases of endoscopic far-lateral supracerebellar infratentorial approach (EF-SCITA) were used to undergo operation ...
Hong Yao, Wenlei Yang, Hao Tang, Yijun Cheng, Shaojian Lin, Zhe Bao Wu   +5 more
doaj   +1 more source