Results 81 to 90 of about 552,864 (311)

Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan, Anna K. McClain, Andrea Trementozzi, Sogu Sohn, Lingxia Qiao, Chi Zhao, Padmini Rangamani, Jeanne C. Stachowiak, Janet Zoldan   +8 more
wiley   +1 more source

Evolution of Minimally Invasive Approaches to the Sella and Parasellar Region

International Archives of Otorhinolaryngology, 2014
Introduction Given advancements in endoscopic image quality, instrumentation, surgical navigation, skull base closure techniques, and anatomical understanding, the endonasal endoscopic approach has rapidly evolved into a widely utilized technique for ...
Robert G. Louis, Amy Eisenberg, Garni Barkhoudarian, Chester Griffiths, Daniel F. Kelly   +4 more
doaj   +1 more source

Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat [PDF]

, 2001
The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress.
Boer, Sietse F. de,, Bohus, Béla,, Buwalda, Bauke,, Felszeghy, Klára,, Horváth, Katalin M.,, Koolhaas, Jaap M.,, Nyakas, Csaba,   +6 more
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Translational Windows in Chordoma: A Target Appraisal

Frontiers in Neurology, 2020
Chordomas are rare tumors that are notoriously refractory to chemotherapy and radiotherapy when radical surgical resection is not achieved or upon recurrence after maximally aggressive treatment.
Samantha E. Hoffman, Sally A. Al Abdulmohsen, Saksham Gupta, Blake M. Hauser, David M. Meredith, Ian F. Dunn, Wenya Linda Bi   +6 more
doaj   +1 more source

The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease [PDF]

, 1988
We investigated the effect of sodium valproate on plasma ACTH and serum cortisol concentrations in different pathological states of ACTH hypersecretion.
Allolio, B., Jaursch-Hancke, C., Kaulen, D., Reincke, Martin, Winkelmann, W.   +4 more
core   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Identifying Facial Features and Predicting Patients of Acromegaly Using Three-Dimensional Imaging Techniques and Machine Learning

Frontiers in Endocrinology, 2020
Objective: Facial changes are common among nearly all acromegalic patients. As they develop slowly, patients often fail to notice such changes before they become obvious. Consequently, diagnosis and treatment are often delayed.
Tian Meng, Xiaopeng Guo, Xiaopeng Guo, Xiaopeng Guo, Wei Lian, Wei Lian, Wei Lian, Kan Deng, Kan Deng, Kan Deng, Lu Gao, Lu Gao, Lu Gao, Zihao Wang, Zihao Wang, Zihao Wang, Jiuzuo Huang, Xiaojun Wang, Xiao Long, Bing Xing, Bing Xing, Bing Xing   +21 more
doaj   +1 more source

Educational Impact of Artificial Intelligence‐Navigation Surgery on Anatomical Landmark Recognition in Medical Students

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the educational impact of artificial intelligence (AI)‐navigation surgery that provides real‐time anatomical landmark recognition during laparoscopic cholecystectomy for medical students. Thirty students were randomized into surgeon‐guided, self‐learning, and AI‐learning groups, and their performance was assessed using Dice ...
Shigeo Ninomiya, Yusuke Matsunobu, Tabito Oyama, Hiroomi Takayama, Takashi Masuda, Teijiro Hirashita, Yuichi Endo, Tatsushi Tokuyasu, Masafumi Inomata   +8 more
wiley   +1 more source

A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A novel hybrid transfer learning approach for brain tumor classification achieves 99.47% accuracy using magnetic resonance imaging (MRI) images. By combining image preprocessing, ensemble deep learning, and explainable artificial intelligence (XAI) techniques like gradient‐weighted class activation mapping and SHapley Additive exPlanations (SHAP), the ...
Sadia Islam Tonni, Md. Alif Sheakh, Mst. Sazia Tahosin, Md. Zahid Hasan, Taslima Ferdaus Shuva, Touhid Bhuiyan, Muhammad Ali Abdullah Almoyad, Nabil Anan Orka, Md. Tanvir Rahman, Risala Tasin Khan, M. Shamim Kaiser, Mohammad Ali Moni   +11 more
wiley   +1 more source