Results 171 to 180 of about 793,066 (378)

The mechanisms in glucose metabolism of aging hippocampus

open access: yesIbrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He   +6 more
wiley   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

open access: yes, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S.   +7 more
core  

ACT001 Inhibits Tumor Progression and Modulates Immune Responses in Non‐Small Cell Lung Cancer

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
ACT001, a novel small‐molecule inhibitor, demonstrates significant antitumoral and immunomodulatory effects in NSCLC by inhibiting cell proliferation, migration, and invasion, inducing cell cycle arrest, and suppressing tumor growth. Mechanistically, it targets STAT1/STAT3, reduces PD‐L1 expression, and enhances granzyme B release in CD3+ T cells ...
Zhijing Shi   +7 more
wiley   +1 more source

Growth but Not Corticosterone, Oxidative Stress, or Telomere Length Is Negatively Affected by Microplastic Exposure in a Filter‐Feeding Amphibian

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Microplastics (MPs) are of increasing global concern for species inhabiting aquatic habitats. However, the mechanisms behind animal responses to MPs still require comprehensive exploration. Amphibians are the most threatened vertebrate group with most species having a complex life cycle, commonly with an aquatic larval stage.
Colette Martin   +3 more
wiley   +1 more source

Elevating Testosterone and Androstenedione Produces Temporary Sex‐Dependent Variation in Japanese Quail (Coturnix japonica) Embryonic Development

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Vertebrate growth rates may respond to maternally supplied steroids, yet injections of individual hormones into avian eggs of different species have produced inconsistent results. This might be because diverse steroids' concentrations are naturally correlated in yolks, injections are not elevating hormones at critical times in development, or ...
S. K. Winnicki   +4 more
wiley   +1 more source

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine   +24 more
wiley   +1 more source

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