Results 1 to 10 of about 322,068 (275)
Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder [PDF]
Journal of Medicine and Life Science, 2021 The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors.
Sung-Cherl Jung +5 more
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Tyk2-mediated homeostatic control by regulating the PGE2-PKA-IL-10 axis
AIMS Allergy and Immunology, 2021 Tyrosine kinase 2 (Tyk2), which associates with the receptors for type I interferon (IFN) and interleukins (IL)-6, IL-10, IL-12, and IL-23, is critical to mediate cytokine-induced signals.
Ryuta Muromoto +2 more
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Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
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PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice [PDF]
Communications Biology, 2021 AbstractTemporal lobe epilepsy (TLE) is one of the most common and intractable neurological disorders in adults. Dysfunctional PKA signaling is causally linked to the TLE. However, the mechanism underlying PKA involves in epileptogenesis is still poorly understood.
Jingliang Zhang +7 more
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Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2020 A theoretical approach to the pKA assessment for dimers of saturated carboxylic acids CnH2n+1COOH( n = 6 - 16) and amines CnH2n+1NH2 (n = 6 — 16) at the air/water interface is proposed.
Yu.B. Vysotsky, E.S. Kartashynska
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The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro
Platelets, 2022 In the clinic, the supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, many scientists have established the derivation of functional platelets from CD34+ cells or human pluripotent stem cells (PSCs).
Weihua Huang +11 more
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Microorganisms, 2020 Efficient utilization of both glucose and xylose from lignocellulosic biomass would be economically beneficial for biofuel production. Recombinant Saccharomyces cerevisiae strains with essential genes and metabolic networks for xylose metabolism can ...
Meiling Wu +8 more
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Electrochemistry, 2021 A voltammetric method has been developed for the determination of the acid dissociation constant (pKa) of (RfSO2)2CHR (Rf = perfluoroalkyl), which is a strongly acidic molecule that serves as an acid catalyst.
Akira KOTANI +3 more
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Synthesis of sulfacetamide and pKa calculation of its derivatives using ab initio methods [PDF]
شیمی کاربردی روز, 2018 Sulfonamides are a class of pharmaceutical compounds included –SO2NH– group that show a variety of biological activities. Sulfacetamide is an N-acyl sulfonamide that has broad-spectrum antibiotic effects.
Mohammad Reza Noorbala +3 more
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High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
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