Results 111 to 120 of about 322,068 (275)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Mistletoe‐ and Mussel‐Inspired Fabrication of Hierarchically Structured Protein‐Cellulose Scaffolds From Biomolecular Condensates

Advanced Materials, EarlyView.
Merging materials processing tricks inspired by mussel and mistletoe fiber fabrication, solutions of cationic mussel byssus proteins were mixed with modified anionic nanocrystalline cellulose, producing distinctive core‐shell condensates. Simple processing of condensate suspensions using freeze‐drying produced hierarchically structured porous protein ...
Hamideh R. Alanagh, Seyed Mohammad Amin Ojagh, Arman Jafari, Xinyu Zhan, Tara Sprules, Alexandre Poulhazan, Houman Savoji, Adam G. Hendricks, Theo G.M. van de Ven, Matthew J. Harrington   +9 more
wiley   +1 more source

Material Preparation Information File (MPIF): A Community‐Driven Standard for Reporting MOF Syntheses

Advanced Materials, EarlyView.
The Material Preparation Information File (MPIF) establishes a universal, community‐driven format for documenting the synthesis of metal–organic frameworks and related materials. By capturing complete, machine‐readable synthesis and characterization details, MPIF enhances reproducibility, supports FAIR data sharing, and bridges experimental chemistry ...
Ocean Cheung, Shun Tokuda, Damian Jędrzejowski, Evelyn Ploetz, Bettina Baumgartner, Marzena Pander, Fengxu Yang, Jack D. Evans, Romy Ettlinger, Stefan Wuttke, Dariusz Matoga   +10 more
wiley   +1 more source

Membrane Semi‐Permeability and Ion Selectivity in Chemiosmosis: Open Systems Volume Dependence of Electrolyte Chemistry

Advanced Materials Interfaces, EarlyView.
Very small cellular compartments can break electroneutrality and harness proton gradients without active transport structures, whereas larger volumes cannot, underscoring why life's critical energy processes are confined in microscopic spaces. ABSTRACT The effect of pH changes in external ionic solutions on liposomes entrapping non‐permeable weak acid ...
Josep M. Ribó, Isabel Herreros, David Hochberg, Federico Morán, Michael Stich   +4 more
wiley   +1 more source

Simulation of weak polyelectrolytes: A comparison between the constant pH and the reaction ensemble method

, 2017
The reaction ensemble and the constant pH method are well-known chemical equilibrium approaches to simulate protonation and deprotonation reactions in classical molecular dynamics and Monte Carlo simulations.
Holm, Christian, Landsgesell, Jonas, Smiatek, Jens   +2 more
core   +1 more source

Self‐Assembled Fluorescent Nanodiamond Layers for Quantum Imaging

Advanced Materials Interfaces, EarlyView.
We developed a simple, scalable method for coating surfaces with fluorescent nanodiamonds. By optimizing the coating process, we created uniform, dense layers that enable high‐resolution magnetic imaging using the nitrogen‐vacancy (NV) center in nanodiamonds. This approach enables the development of cost‐effective quantum‐sensing and imaging substrates
Katherine Chea, Erin S. Grant, Kevin J. Rietwyk, Hiroshi Abe, Takeshi Ohshima, David A. Broadway, Jean‐Philippe Tetienne, Gary Bryant, Philipp Reineck   +8 more
wiley   +1 more source

Amido‐Amine Co(II) Precursor‐Based Atomic/Molecular Layer Deposition Processes for Cobalt‐Organic Thin Films and Their Thermal Conversion to CoO Thin Films

Advanced Materials Technologies, EarlyView.
Three new atomic/molecular layer deposition processes are developed for Co‐organic thin films using a promising all‐nitrogen‐coordinated cobalt precursor. The study examines film growth, reaction mechanisms, chemical stability, and decomposition pathways of the resulting films through extensive characterization techniques and DFT calculations ...
Topias Jussila, Jorit Obenlüneschloß, Ji Liu, Olga Partanen, Sami Vasala, Detlef Rogalla, Pieter Glatzel, Michael Nolan, Anjana Devi, Maarit Karppinen   +9 more
wiley   +1 more source

Origin of the unique topology of the triangular water cluster in Rubrobacter xylanophilus rhodopsin

Biophysics and Physicobiology
The crystal structure of Rubrobacter xylanophilus rhodopsin (RxR) reveals a triangular cluster of three water molecules (W413, W415, and W419) at the extracellular proton-release site, near Glu187 and Glu197.
Tomoyasu Noji, Masaki Tsujimura, Keisuke Saito, Keiichi Kojima, Yuki Sudo, Hiroshi Ishikita   +5 more
doaj   +1 more source

pH dependence of charge multipole moments in proteins

, 2017
Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the changes in the ...
Bozic, Anze Losdorfer, Podgornik, Rudolf
core   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source