Results 21 to 30 of about 322,068 (275)

Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) [PDF]

, 2015
Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1.
Baillie, George, Sin, Yuan Yan
core   +1 more source

Exploring the pKa, Molecular Binding, and Caspase-3 Activation Potential of Coumarin Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Caspase-3 is a central executioner protease in apoptosis, and its activation by small molecules is considered a promising anticancer strategy. Coumarin derivatives are known for their diverse biological activities, but the influence of structural ...
Semra Altunterim Erkan, Emine Erdag, Louai Alsaloumi, Hayati Celik   +3 more
doaj   +1 more source

Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]

, 2017
Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio, D\u2019Avella, Domenico, Denaro, Luca, Mucignat-Caretta, Carla   +3 more
core   +2 more sources

Conceptual DFT as a Novel Chemoinformatics Tool for Studying the Chemical Reactivity Properties of the Amatoxin Family of Fungal Peptides

Open Chemistry, 2019
The chemical structures and molecular reactivities of the Amatoxin group of fungi-derived peptides have been determined by means of the consideration of a model chemistry that has been previously validated as well-behaved for our purposes. The reactivity
Flores-Holguín Norma, Frau Juan, Glossman-Mitnik Daniel   +2 more
doaj   +1 more source

Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP

Cells, 2020
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2).
Alessandro Dema, Dörte Faust, Katina Lazarow, Marc Wippich, Martin Neuenschwander, Kerstin Zühlke, Andrea Geelhaar, Tamara Pallien, Eileen Hallscheidt, Jenny Eichhorst, Burkhard Wiesner, Hana Černecká, Oliver Popp, Philipp Mertins, Gunnar Dittmar, Jens Peter von Kries, Enno Klussmann   +16 more
doaj   +1 more source

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

Adipocyte, 2020
The prevalence of obesity and its comorbidities has sparked a worldwide concern to address rates of adipose tissue accrual. Recent studies have demonstrated a novel role of Zyflamend, a blend of natural herbal extracts, in regulating lipid metabolism in ...
Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan, Ahmed Bettaieb   +8 more
doaj   +1 more source

Applicability of hybrid micelle liquid chromatography for practical determination of acid dissociation constant

Journal of Taibah University for Science, 2022
Hybrid micellar liquid chromatography was used for practical determination of acid dissociation constant (pKa) of three analytes, namely, ibuprofen (IBU), naproxen (NPX) and benzoic acid (BZA).
M. E. K. Wahba, D. El Sherbiny
doaj   +1 more source

OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program [PDF]

, 2019
A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic circuits mediating developmental decisions. A model in organogenesis is provided by the sex-specific
Chen, Yen-Shan, Phillips, Nelson, Racca, Joseph, Weiss, Michael   +3 more
core   +1 more source

Molecular pKa Prediction with Deep Learning and Chemical Fingerprints

Cumhuriyet Science Journal
Today, drug discovery and design, the determination of molecular properties, in particular the determination of a molecule's pKa value, is essential for understanding and optimising the biological activity of drugs.
Fatih Mehmet Avcu
doaj   +1 more source

Potential and limitations of PKA/ PKG inhibitors for platelet studies

Platelets, 2022
Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova, Natalia Rukoyatkina, Ulrich Walter, Stepan Gambaryan   +3 more
doaj   +1 more source