Results 41 to 50 of about 320,211 (227)

MF-SuP-pKa: Multi-fidelity modeling with subgraph pooling mechanism for pKa prediction

Acta Pharmaceutica Sinica B, 2023
Acid-base dissociation constant (pKa) is a key physicochemical parameter in chemical science, especially in organic synthesis and drug discovery. Current methodologies for pKa prediction still suffer from limited applicability domain and lack of chemical
Jialu Wu, Yue Wan, Zhenxing Wu, Shengyu Zhang, Dongsheng Cao, Chang-Yu Hsieh, Tingjun Hou   +6 more
doaj   +1 more source

Theoretical study on the protonation of AZA-aromatics [PDF]

, 1975
The protonation of azanaphthalenes and azabenzenes has been studied theoretically using CNDO/2 wavefunctions and perturbation theory in order to examine the correlation between pKa values and quantum-mechanical ...
Meer, Douwe van der, Weijer, Peter van de   +1 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The Potentially Therapeutic Role of EPAC in Curbing the Process of Idiopathic Pulmonary Fibrosis via Differential Cellular Pathways

Journal of Inflammation Research, 2021
Xinwei Cao,1 Yajun Li,1 Jianrong Shi,2 Huifang Tang1 1Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital ...
Cao X, Li Y, Shi J, Tang H
doaj  

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination

Cells, 2019
Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary ...
Neus Garcia, Cori Balañà, Maria A. Lanuza, Marta Tomàs, Víctor Cilleros-Mañé, Laia Just-Borràs, Josep Tomàs   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Molecules, 2019
Great effort is put into seeking a new and effective strategies to control insect pests. One of them is to combine natural products with chemical insecticides to increase their effectiveness.
Milena Jankowska, Justyna Wiśniewska, Łukasz Fałtynowicz, Bruno Lapied, Maria Stankiewicz   +4 more
doaj   +1 more source

Phase-dependent molecular requirements for memory reconsolidation: differential roles for protein synthesis and protein kinase A activity [PDF]

, 2006
After consolidation, a process that requires gene expression and protein synthesis, memories are stable and highly resistant to disruption by amnestic influences.
Kemenes, György, Kemenes, Ildikó, Michel, Maximilian, Mueller, Uli, Papp, Andrea   +4 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum japonicum. Methods: The cytotoxicity of ligustroside was tested via MTT assay.
Xian-Rong Zhou, Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Chang-Suk Kong   +4 more
doaj   +1 more source