Results 161 to 170 of about 95,096 (261)

Empagliflozin-pirfenidone dual therapy improves cardiac function and structure in a preclinical two-hit HFpEF model. [PDF]

Front Pharmacol
Yu Y, Xu Y, Chen J, Yao Y, Liu Y, Huang T, Yang S, Ling KH, Guyette JP, Shaharuddin B, Guo Z, Tan JJ.   +11 more
europepmc   +1 more source

Quality of life assessment for colorectal cancer follow‐up: A latent profile analysis of EORTC measures

Colorectal Disease, Volume 28, Issue 8, August 2026.
Abstract Aim To identify distinct health‐related quality of life (HRQoL) profiles among colorectal cancer (CRC) patients using patient‐reported outcome measures (PROMs), with the aim of informing more personalised follow‐up strategies. Methods Baseline HRQoL data from CRC patients enrolled in the FUTURE‐primary study, a multicentre implementation study
M. H. Elise van Driel, Lissa Wullaert, Kelly R. Voigt, Pascal G. Doornebosch, Koen C. M. J. Peeters, Jennifer M. J. Schreinemakers, Maria Verseveld, Cornelis Verhoef, Dirk J. Grünhagen, Olga Husson, Martijn A. H. Oude Voshaar   +10 more
wiley   +1 more source

PKC isoform-specific targeting of the phosphorylation site Serine¹⁹¹ in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity. [PDF]

Pflugers Arch
Inderwiedenstraße L, Kienitz MC.
europepmc   +1 more source

Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double‐Blind Phase II Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7073-7082, August 2026.
ABSTRACT Aim This study aimed to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in Chinese adults with T2DM and to preliminarily compare its efficacy and safety with semaglutide through multiple subcutaneous injections. Materials and Methods In this multicentre, randomised, placebo‐controlled and semaglutide‐positive‐
Ping Jin, Linong Ji, Yangqing Huang, Haifeng Ding, Daosheng Xie, Xiaohui Jiang, Xuemei Yuan, Zhao Cao, Haibin Zhang, Jiandong Yuan   +9 more
wiley   +1 more source

PKC-iota drives EGFR-TKI resistance in EGFR-mutated NSCLC by phosphorylating FASN to reprogram lipid metabolism. [PDF]

Transl Lung Cancer Res
Ma L, Han Y, Xu L, Sun Q, Song S, Yang H, Chen X, Xie W, Chen Y, Liu L.   +9 more
europepmc   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Special Issue "Recent Advances of Natural Products in Chemical and Biological Aspects". [PDF]

Int J Mol Sci
Les F, Valero MS, Arruebo MP.
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases. [PDF]

Chembiochem
Abbura T, Morris MC.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source