Results 161 to 170 of about 97,124 (258)

Design of PKC-Targeting Benzolactams as Gli Inhibitors. [PDF]

ACS Med Chem Lett
Haddad M, Chvatal J, Kifer A, Herdrich J, Poljak M, Billingsley KL.   +5 more
europepmc   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

PKCα-deficient mice show altered synaptic signaling and impaired fear extinction. [PDF]

Neurobiol Stress
An L, Yang M, Ding Q, Wang H.
europepmc   +1 more source

First‐In‐Human Study of Mirogabalin (BM2216) Sustained‐Release Tablets: Safety, Tolerability, Pharmacokinetics, Food Effect and Dose Proportionality With Comparison to Mirogabalin Besylate in Healthy Participants

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10795-10813, November 2026.
ABSTRACT Aim To characterise the pharmacokinetics (PKs) and safety of BM2216 sustained‐release (SR) tablets after single‐dose oral administration under fasted/fed conditions in healthy participants, assess the effect of food and dose proportionality, and compare the single and multiple‐dose PK of BM2216 SR tablets with mirogabalin besylate tablets to ...
Peiyang Song, Hongtao Zhao, Mingxue Zhu, Lei Wan, Yuan Chen, Zhongping Li, Chengyong Tang   +6 more
wiley   +1 more source

Editorial Note: Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

cAMP-Activated EPAC Signaling Is an Integral Component of Cardiac Pacemaker Cell Automaticity. [PDF]

Circ Arrhythm Electrophysiol
Vinogradova TM, Riordon DR, Yang D, Tarasov KV, Tarasova YS, Ziman B, Lakatta EG.   +6 more
europepmc   +1 more source

One‐Step Synthesis of Size‐Controlled Copper Oxide Nanoparticles on Laser‐Induced Graphene Sensor for L‐Cysteine Detection

Advanced Electronic Materials, Volume 12, Issue 19, 12 October 2026.
Oxygen plasma treatment enhances polyimide hydrophilicity and promotes uniform anchoring of copper ion precursors. A one‐step laser process then generates CuO‐decorated nanoparticles on laser‐induced graphene (LIG) electrodes, enabling controlled nanoparticle growth via precursor concentration tuning.
Gustavo Miguel Sousa, Ketley Caroline Rocha Pereira, Deissy Johanna Feria Garnica, Marcos Rocha Diniz da Silva, Matheus Santos Dias, Camila Marchetti Maroneze, Cecilia de Carvalho Castro Silva   +6 more
wiley   +1 more source

Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4⁺ T-cell activation. [PDF]

Front Immunol
Maeda K, Campbell PL, Wu Q, Tsou PS, Cooney LA, Mao-Draayer Y, Fox DA, Gurrea-Rubio M.   +7 more
europepmc   +1 more source

MIND diet–related plasma proteins are associated with Alzheimer's disease risk

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Adherence to the Mediterranean–Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet is associated with reduced dementia risk, but underlying mechanisms remain unclear. METHODS Plasma proteomics (SomaScan 7k) from 206 Indiana Alzheimer's Disease Research Center participants were analyzed ...
Shane Fernandez, Desarae A. Dempsey, Soumilee Chaudhuri, Yen‐Ning Huang, Tamina Park, Shiwei Liu, Frederick W. Unverzagt, Sujuan Gao, Global Neurodegeneration Proteomics Consortium, Donna M. Wilcock, Jiaqi Yang, Casey M. Rebholz, Shannon L. Risacher, Andrew J. Saykin, Kwangsik Nho   +14 more
wiley   +1 more source