Results 191 to 200 of about 95,096 (261)

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam   +3 more
wiley   +1 more source

Combining Mendelian Randomization and Experimental Validation to Reveal the Causal Relationship Between Hallux Valgus and Serum Metabolites and to Identify Their Therapeutic Targets and Relevant Components

open access: yesFood Science &Nutrition, Volume 14, Issue 7, July 2026.
This study employed a two‐sample Mendelian randomization approach to investigate the causal relationship between 1400 serum metabolites and hallux valgus (HV). Cysteine was identified as a key metabolite with a significant negative causal association with HV.
Xin Li   +7 more
wiley   +1 more source

Brain-derived microvesicles induce activation of aspirin-treated platelets via the PLC/PKC pathway. [PDF]

open access: yesSci Rep
He YF   +7 more
europepmc   +1 more source

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

open access: yesGenes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li   +5 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

open access: yesInterdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione   +2 more
wiley   +1 more source

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 13, July 2026.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo   +5 more
wiley   +1 more source

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