The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites
Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with ...
Elena K. Schneider +10 more
doaj +1 more source
BackgroundThe strengthening or substitution of intravenous cytotoxic chemotherapy cycles by oral targeted anticancer therapies, such as protein kinase inhibitors (PKIs), has provided impressive clinical benefits and autonomy as well as a better quality ...
Carole Bandiera +20 more
doaj +1 more source
Spillover in Sustainable Consumer Behavior: A Matter of Commitment
ABSTRACT Consumers express their commitment to environmental protection by engaging in a variety of environmentally protective behaviors. We thus suggest that strengthening consumers' commitment to environmental protection will cause behavioral spillover, which is the joint change in multiple environmentally protective behaviors. This idea differs from
Laura Henn +4 more
wiley +1 more source
Practical Implementation of Various Public Key Infrastructure Models
The paper proposes a short comparative analysis of the contemporary models of public key infrastructure (PKI) and the issues of the PKI models real implementation. The Russian model of PKI is presented.
Dmitriy Anatolievich Melnikov +3 more
doaj
Transformative Learning for Controversial History of G 30 S/PKI
G 30 S/PKI is a controversial issue in Indonesian history and a sensitive material because of past traumatic memories. It is a challenge for history teachers in learning in schools.
Yudi Hartono, Khoirul Huda
doaj +1 more source
A Semidecentralized PKI System Based on Public Blockchains with Automatic Indemnification Mechanism [PDF]
Gwan‐Hwan Hwang +2 more
openalex +1 more source
N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activation
Abstract The RIβ subunit of cAMP‐dependent protein kinase (PKA) is highly expressed in the brain, yet it remains the least studied of the PKA regulatory subunits (R). As pathologic variants of its gene are increasingly implicated in neurodevelopmental disorders, neurodegeneration, and cancer, gaining more information about the structure/function of RIβ,
Jian Wu +6 more
wiley +1 more source
Fenomena Kehidupan Keturunan Eks Partai Komunis Indonesia Di Kabupaten Banyuwangi Tahun 2018
This type of phenomenological qualitative research intends to explore and describe the religious, social and cultural life of people descended from the former Indonesian Communist Party (PKI) in the Banyuwangi Regency. By analyzing interactive model data,
Mundir Mundir
doaj +1 more source
Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. [PDF]
The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors.
Hilda H T Au, Eric Jan
doaj +1 more source
Blockchain-based high transparent PKI authentication protocol
The public key infrastructure (PKI), as an significant component of the current Internet security infrastructure, guarantees the information transmission with the necessary authenticity, integrity, confidentiality and non-repudiation.However, the ...
Liquan CHEN +1 more
doaj +1 more source

