Results 51 to 60 of about 65,702 (193)

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

open access: yesERJ Open Research, 2018
Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with ...
Elena K. Schneider   +10 more
doaj   +1 more source

Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data

open access: yesJMIR Research Protocols, 2021
BackgroundThe strengthening or substitution of intravenous cytotoxic chemotherapy cycles by oral targeted anticancer therapies, such as protein kinase inhibitors (PKIs), has provided impressive clinical benefits and autonomy as well as a better quality ...
Carole Bandiera   +20 more
doaj   +1 more source

Spillover in Sustainable Consumer Behavior: A Matter of Commitment

open access: yesJournal of Consumer Behaviour, Volume 24, Issue 6, Page 3152-3168, November 2025.
ABSTRACT Consumers express their commitment to environmental protection by engaging in a variety of environmentally protective behaviors. We thus suggest that strengthening consumers' commitment to environmental protection will cause behavioral spillover, which is the joint change in multiple environmentally protective behaviors. This idea differs from
Laura Henn   +4 more
wiley   +1 more source

Practical Implementation of Various Public Key Infrastructure Models

open access: yesБезопасность информационных технологий, 2016
The paper proposes a short comparative analysis of the contemporary models of public key infrastructure (PKI) and the issues of the PKI models real implementation. The Russian model of PKI is presented.
Dmitriy Anatolievich Melnikov   +3 more
doaj  

Transformative Learning for Controversial History of G 30 S/PKI

open access: yesParamita: Historical Studies Journal, 2020
G 30 S/PKI is a controversial issue in Indonesian history and a sensitive material because of past traumatic memories. It is a challenge for history teachers in learning in schools.
Yudi Hartono, Khoirul Huda
doaj   +1 more source

N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activation

open access: yesProtein Science, Volume 34, Issue 11, November 2025.
Abstract The RIβ subunit of cAMP‐dependent protein kinase (PKA) is highly expressed in the brain, yet it remains the least studied of the PKA regulatory subunits (R). As pathologic variants of its gene are increasingly implicated in neurodevelopmental disorders, neurodegeneration, and cancer, gaining more information about the structure/function of RIβ,
Jian Wu   +6 more
wiley   +1 more source

Fenomena Kehidupan Keturunan Eks Partai Komunis Indonesia Di Kabupaten Banyuwangi Tahun 2018

open access: yesJurnal Darussalam: Jurnal Pendidikan, Komunikasi dan Pemikiran Hukum Islam, 2019
This type of phenomenological qualitative research intends to explore and describe the religious, social and cultural life of people descended from the former Indonesian Communist Party (PKI) in the Banyuwangi Regency. By analyzing interactive model data,
Mundir Mundir
doaj   +1 more source

Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. [PDF]

open access: yesPLoS ONE, 2012
The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors.
Hilda H T Au, Eric Jan
doaj   +1 more source

Blockchain-based high transparent PKI authentication protocol

open access: yes网络与信息安全学报, 2022
The public key infrastructure (PKI), as an significant component of the current Internet security infrastructure, guarantees the information transmission with the necessary authenticity, integrity, confidentiality and non-repudiation.However, the ...
Liquan CHEN   +1 more
doaj   +1 more source

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