Results 51 to 60 of about 21,725 (207)

Machine Learning Based Diagnostic Models for Hip and Knee Prosthetic Joint Infection: A Systematic Review

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
ABSTRACT Prosthetic joint infection (PJI) is a devastating complication that affects up to 1.7% of patients within 2 years following total hip arthroplasty (THA) or total knee arthroplasty (TKA). PJI is associated with significant patient morbidity, reduction in quality of life, prolonged hospitalisation, and healthcare expenditure.
Jaiden Nairne‐Nagy, Rudraksh Gupta, Boopalan Ramasamy, Lucian Bogdan Solomon, Stuart A. Callary   +4 more
wiley   +1 more source

Practical Implementation of Various Public Key Infrastructure Models

Безопасность информационных технологий, 2016
The paper proposes a short comparative analysis of the contemporary models of public key infrastructure (PKI) and the issues of the PKI models real implementation. The Russian model of PKI is presented.
Dmitriy Anatolievich Melnikov, Vitaliy Grigorievich Ivanenko, Tatiana Alexandrovna Kondratyeva, Anton Dmitrievich Melnikov   +3 more
doaj  

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

ERJ Open Research, 2018
Ivacaftor–lumacaftor and ivacaftor are two new breakthrough cystic fibrosis transmembrane conductance modulators. The interactions of ivacaftor and its two metabolites hydroxymethylivacaftor (iva-M1) and ivacaftorcarboxylate (iva-M6) with ...
Elena K. Schneider, Rachel M. McQuade, Vincenzo C. Carbone, Felisa Reyes-Ortega, John W. Wilson, Brenda Button, Ayame Saito, Daniel P. Poole, Daniel Hoyer, Jian Li, Tony Velkov   +10 more
doaj   +1 more source

Transformative Learning for Controversial History of G 30 S/PKI

Paramita: Historical Studies Journal, 2020
G 30 S/PKI is a controversial issue in Indonesian history and a sensitive material because of past traumatic memories. It is a challenge for history teachers in learning in schools.
Yudi Hartono, Khoirul Huda
doaj   +1 more source

Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data

JMIR Research Protocols, 2021
BackgroundThe strengthening or substitution of intravenous cytotoxic chemotherapy cycles by oral targeted anticancer therapies, such as protein kinase inhibitors (PKIs), has provided impressive clinical benefits and autonomy as well as a better quality ...
Carole Bandiera, Evelina Cardoso, Isabella Locatelli, Antonia Digklia, Khalil Zaman, Antonella Diciolla, Valérie Cristina, Athina Stravodimou, Aedo Lopez Veronica, Ana Dolcan, Apostolos Sarivalasis, Aikaterini Liapi, Hasna Bouchaab, Angela Orcurto, Jennifer Dotta-Celio, Solange Peters, Laurent Decosterd, Nicolas Widmer, Dorothea Wagner, Chantal Csajka, Marie Paule Schneider   +20 more
doaj   +1 more source

Effects of Autophagy Inhibition by SAR405, a Selective VPS34 Inhibitor, on Pleural Mesothelioma Cells

Thoracic Cancer, Volume 17, Issue 5, March 2026.
SAR405, a selective VPS34 inhibitor, suppressed autophagic flux and reduced cell viability, colony formation, and invasion in pleural mesothelioma cell lines. SAR405 induced apoptosis only in H2452 cells. Cisplatin weakly induced autophagy, but its combination with SAR405 showed no synergistic cytotoxic effects. ABSTRACT Background Pleural mesothelioma
Yoshiki Kuwabara, Kosuke Sakai, Kota Shiraishi, Itsuka Matsumoto, Shigeru Ishii, Shin Yokosuka, Masatoshi Abe, Tomoyuki Takahashi, Yuichiro Kawano, Hiroaki Nishimura, Maiko Toda‐Sasaki, Yumiko Kobayashi‐Ogawa, Satoshi Kikuchi, Yusuke Hirata, Hiroyuki Kyoyama, Gaku Moriyama, Nobuyuki Koyama, Kazutsugu Uematsu   +17 more
wiley   +1 more source

Toward a global repository of insect traits (GRIT)

Insect Conservation and Diversity, Volume 19, Issue 2, Page 253-267, March 2026.
Biodiversity loss is accelerating, yet insect conservation is hindered by the absence of a centralised, comprehensive trait database. We propose the GRIT, a FAIR, open‐access platform uniting datasets and collaborators worldwide. GRIT will harness advanced computational tools for trait acquisition and imputation, enabling large‐scale ecological ...
Pedro Cardoso, Nathan Jay Baker, Mário Boieiro, Dries Bonte, Paulo A. V. Borges, Michael F. Braby, Vasco Branco, Dragan Chobanov, Luis Correia, Daniel T. Dalton, Mariana Damas‐Mora, Raphael K. Didham, Lynne Forster, Richard Glatz, Jacob A. Gorneau, Axel Hochkirch, Ameli Kirse, Elinor M. Lichtenberg, Nuria Macías‐Hernández, Marija Miličić, Melinda Moir, Pablo Moreno‐García, Ruth Neessen, Jorge Ari Noriega, Clint A. Penick, Kayla I. Perry, James Pryke, Carla Rego, Karl A. Roeder, Stéphanie Saussure, Vaughn Shirey, Pasi Sihvonen, Ilja Svetnik, Sergei Tarasov, Pedro Trindade, Ellen A. R. Welti, Mark Wong, Christoph Scherber   +37 more
wiley   +1 more source

A QSAR Study of HIV Protease Inhibitors Using Computational Descriptors to Prediction of pki of Cycle Derivatives of Urea

Bihdād, 2020
Preventing and reducing the spread of HIV (HIV) has always been a concern in medical science. One of the most common ways to control the virus is using enzyme-blocking drugs. In this study, we attempted to predict the biological activity (PKi) of organic
Zakiyeh Bayat, Samaneh Mohamad Ebrahimzadeh Sepasgozar   +1 more
doaj  

Fenomena Kehidupan Keturunan Eks Partai Komunis Indonesia Di Kabupaten Banyuwangi Tahun 2018

Jurnal Darussalam: Jurnal Pendidikan, Komunikasi dan Pemikiran Hukum Islam, 2019
This type of phenomenological qualitative research intends to explore and describe the religious, social and cultural life of people descended from the former Indonesian Communist Party (PKI) in the Banyuwangi Regency. By analyzing interactive model data,
Mundir Mundir
doaj   +1 more source

Insights into factorless translational initiation by the tRNA-like pseudoknot domain of a viral IRES. [PDF]

PLoS ONE, 2012
The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors.
Hilda H T Au, Eric Jan
doaj   +1 more source