The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
Cancer Communications, 2021 Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.
Jing‐Zi Wang +12 more
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USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2.
PLoS ONE, 2023 BackgroundThe pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect.
Yuanyuan Chen +5 more
doaj +2 more sources
PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer [PDF]
Scientific ReportsOne of the main characteristics of tumor metabolite reprogramming is enhanced glycolysis, and Pyruvate Kinase M2(PKM2) is a crucial enzyme that limits the pace of glycometabolism. Although PKM2 has been proven to affect the development of some cancers, a
Haosheng Zheng +8 more
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Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice [PDF]
Frontiers in PharmacologyIntroduction:Pyruvate kinase M2 (PKM2), the rate-limiting enzyme of glycolysis, plays a critical role in macrophage activation and a broad spectrum of chronic liver diseases.
Ziwei Kang +14 more
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Theranostics, 2021 Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are still unclear.
Dongliang Wang +11 more
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PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la/ NF-κB induced neuroinflammation and mitochondrial damage [PDF]
Scientific ReportsThis study aims to explore the effects and potential mechanisms of PKM2-mediated neuroinflammation leading to mitochondrial damage and its role in the progression of chronic fatigue syndrome (CFS).
Meng Sun +3 more
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Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]
PeerJ, 2020 Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang +4 more
doaj +2 more sources
GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma [PDF]
Cell Death and DiseaseHepatocellular carcinoma (HCC) is one of the most common malignant tumors. Abnormally high expression of Golgi protein 73 (GP73) and pyruvate kinase M2 (PKM2) is intimately associated with HCC progression. However, as secreted proteins, the role of their
Shujie Wang +9 more
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Journal of experimental & clinical cancer research : CR, 2023 Background The response rate to immunotherapy in patients with bladder cancer (BCa) remains relatively low. Considering the stable existence and important functions in tumour metabolism, the role of circRNAs in regulating immune escape and immunotherapy ...
Jiancheng Lv +12 more
semanticscholar +1 more source
Nature Communications, 2023 Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely on glycolysis for energy production, little is known about the role of glycolysis in ECs senescence.
Yinsheng Wu +9 more
semanticscholar +1 more source