Results 1 to 10 of about 16,547 (202)
Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis [PDF]
Animal Models and Experimental Medicine, 2023 Background The expression of pyruvate kinase muscle 2 (PKM2) is augmented in macrophages of patients with atherosclerotic coronary artery disease. The role of PKM2 in atherosclerosis is to be determined.
Xiaochen Gai +13 more
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Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment [PDF]
BiomoleculesThe aberrant activation of glycolysis plays a pivotal role in the progression of liver diseases. Pyruvate kinase M2 (PKM2), one of the rate-limiting enzymes of glycolysis, not only regulates cellular metabolism but also translocates to the nucleus in its
Xiaoya Zhang +4 more
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Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]
PeerJ, 2020 Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang +4 more
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USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2.
PLoS ONE, 2023 BackgroundThe pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect.
Yuanyuan Chen +5 more
doaj +1 more source
Viruses, 2021 Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee +4 more
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Frontiers in Pharmacology, 2021 Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in cell proliferation, which is a rate-limiting enzyme that regulates the final step of ...
Yun-zi Liu +16 more
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Cancer & Metabolism, 2018 Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer.
Talya L. Dayton +7 more
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PKM2 is not required for pancreatic ductal adenocarcinoma
Cancer & Metabolism, 2018 Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models.
Alissandra L Hillis +6 more
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HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells. [PDF]
PLoS ONE, 2014 Pyruvate kinase M2 (PKM2) is predominantly expressed in cancers, which is considered as a key regulator of the Warburg effect. In this study, HSP40 was identified as a novel binding partner of PKM2.
Liangqian Huang +4 more
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The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
Cancer Communications, 2021 Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.
Jing‐Zi Wang +12 more
doaj +1 more source