Results 1 to 10 of about 25,196 (274)

Structural basis of PKM2 regulation [PDF]

Protein & Cell, 2015
Alterations in cell metabolism are a characteristic of many cancers. Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang, 2006; Vander Heiden et al., 2009). The best-characterized metabolic phenotype observed in tumor cells is aerobic glycolysis, also known as the Warburg effect, which is a shift of ATP generation from ...
Weiwei Yang
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PKM2 and the Tricky Balance of Growth and Energy in Cancer [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.
Andrew N. Macintyre, Jeffrey C. Rathmell
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Lack of Evidence for PKM2 Protein Kinase Activity [PDF]

Molecular Cell, 2015
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activity is lacking. Using [(32)P]-phosphoenolpyruvate (PEP)
Aaron M. Hosios, Brian P. Fiske, Dan Y. Gui, Matthew G. Vander Heiden   +3 more
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PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]

, 2015
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
A Barbarulo, AE Vaughn, AJ Levine, B Chaneton, C Bubici, CC Wong, CV Dang, D Anastasiou, D Anastasiou, D Beyoğlu, D Beyoğlu, DY Gui, E Kakazu, E Wurmbach, GK Abou-Alfa, H Ke, H Mohammed, H Shim, HJ Huber, HR Christofk, HR Christofk, JL Andersen, JS Boehm, K Bensaad, K Herzer, K Kitamura, K Wang, L Lv, L Lv, M Cortés-Cros, M Hatziapostolou, M Wiznerowicz, MG Vander Heiden, NM Grüning, NN Danial, P Chinnaiyan, P Mehrotra, Q Geissmann, R Koschny, R Ma, R Yang, RA Cairns, RA Gatenby, RG Jones, S Papa, SH Cho, SH Cho, SK McBrayer, SM Jang, SY Peng, T Amann, T Hitosugi, T Hitosugi, T Yamashita, T Yanagawa, TH Nguyen, V Schreiber, W Luo, W Yang, WJ Israelsen, Y Hoshida, Z Chen   +61 more
core   +4 more sources

PKM2 promotes reductive glutamine metabolism

Cancer Biology & Medicine, 2018
Pyruvate kinases M (PKM), including the PKM1 and PKM2 isoforms, are critical factors in glucose metabolism. PKM2 promotes aerobic glycolysis, a phenomenon known as " the Warburg effect". The purpose of this study was to identify the roles of PKM2 in regulating cellular metabolism.The CRISPR/Cas9 system was used to generate the PKM-knockout cell model ...
Miao Liu, Yuan‐Yuan Wang, Ruan Yuxia, Changsen Bai, Qiu Li, Cui Yanfen, Guoguang Ying, Binghui Li   +7 more
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PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis [PDF]

Nature Communications, 2016
AbstractMany types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified.
Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang, Zhimin Lu   +8 more
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Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

Theranostics, 2021
Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are still unclear.
Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang   +11 more
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PKM2-mediated metabolic reprogramming of microglia in neuroinflammation. [PDF]

Cell Death Discov
Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic enzyme, and its impact on microglial ...
Zhang Q, Wang SS, Zhang Z, Chu SF.
europepmc   +4 more sources

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma [PDF]

, 2014
Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome.
Lynam-Lennon, Niamh, Maguire, Aoife, Maher, Stephen G., Muldoon, Cian, O'Sullivan, Jacintha, O’Sullivan, Jacintha, Phelan, James, Reynolds, John V.   +7 more
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The Role of PKM2 in Diabetic Microangiopathy

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of life of affected patients.
Chao Tu, Liangzhi Wang, Lan Wei
openaire   +4 more sources