Results 1 to 10 of about 22,396 (185)

PKM2 is not required for pancreatic ductal adenocarcinoma [PDF]

Cancer & Metabolism, 2018
Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models.
Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio, Matthew G Vander Heiden   +6 more
doaj   +5 more sources

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis

Animal Models and Experimental Medicine, 2023
Background The expression of pyruvate kinase muscle 2 (PKM2) is augmented in macrophages of patients with atherosclerotic coronary artery disease. The role of PKM2 in atherosclerosis is to be determined.
Xiaochen Gai, Fangming Liu, Yuting Wu, Baohui Zhang, Bufu Tang, Kezhuo Shang, Lianmei Wang, Haihong Zhang, Yixin Chen, Shuhui Yang, Weiwei Deng, Peng Li, Jing Wang, Hongbing Zhang   +13 more
doaj   +3 more sources

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment [PDF]

Biomolecules
The aberrant activation of glycolysis plays a pivotal role in the progression of liver diseases. Pyruvate kinase M2 (PKM2), one of the rate-limiting enzymes of glycolysis, not only regulates cellular metabolism but also translocates to the nucleus in its
Xiaoya Zhang, Danmei Zhang, Jin Guo, Chunxia Shi, Zuojiong Gong   +4 more
doaj   +2 more sources

Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma [PDF]

, 2014
Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome.
Lynam-Lennon, Niamh, Maguire, Aoife, Maher, Stephen G., Muldoon, Cian, O'Sullivan, Jacintha, O’Sullivan, Jacintha, Phelan, James, Reynolds, John V.   +7 more
core   +16 more sources

Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]

PeerJ, 2020
Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang, Yingying Zhong, Jiecong Liang, Zhibin Li, Yun Ye   +4 more
doaj   +2 more sources

The Role of PKM2 in Diabetic Microangiopathy

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of life of affected patients.
Chao Tu, Liangzhi Wang, Lan Wei
openaire   +4 more sources

PKM2, function and expression and regulation [PDF]

Cell & Bioscience, 2019
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has ...
Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun, Fangfang Chen   +5 more
openaire   +3 more sources

A PKM2 signature in the failing heart [PDF]

Biochemical and Biophysical Research Communications, 2015
A salient feature of the failing heart is metabolic remodeling towards predominant glucose metabolism and activation of the fetal gene program. Sunitinib is a multitargeted receptor tyrosine kinase inhibitor used for the treatment of highly vascularized tumors. In diabetic patients, sunitinib significantly decreases blood glucose.
Meredith L. Rees, Janani Subramaniam, Yuanteng Li, Dale J. Hamilton, O. Howard Frazier, Heinrich Taegtmeyer   +5 more
openaire   +2 more sources

PKM2 Enters the Morpheein Academy [PDF]

Molecular Cell, 2012
In this issue of Molecular Cell, Gao et al. (2012) show that the glycolytic enzyme PKM2, in its dimeric form, possesses protein kinase activity and phosphorylates STAT3 in the nucleus, thereby driving expression of genes that promote transformation.
Semenova, Galina, Chernoff, Jonathan
openaire   +2 more sources

USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2.

PLoS ONE, 2023
BackgroundThe pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect.
Yuanyuan Chen, Yunfei Guo, Mei Yuan, Song Guo, Shuaishuai Cui, Dahu Chen   +5 more
doaj   +1 more source