Results 1 to 10 of about 14,270 (217)

PKM2 is not required for pancreatic ductal adenocarcinoma [PDF]

Cancer & Metabolism, 2018
Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models.
Alissandra L Hillis, Allison N Lau, Camille X Devoe, Talya L Dayton, Laura V Danai, Dolores Di Vizio, Matthew G Vander Heiden   +6 more
doaj   +6 more sources

Structural basis of PKM2 regulation [PDF]

Protein & Cell, 2015
Alterations in cell metabolism are a characteristic of many cancers. Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang, 2006; Vander Heiden et al., 2009). The best-characterized metabolic phenotype observed in tumor cells is aerobic glycolysis, also known as the Warburg effect, which is a shift of ATP generation from ...
Weiwei Yang
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PKM2 and the Tricky Balance of Growth and Energy in Cancer [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.
Andrew N. Macintyre, Jeffrey C. Rathmell
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Lack of Evidence for PKM2 Protein Kinase Activity [PDF]

Molecular Cell, 2015
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activity is lacking. Using [(32)P]-phosphoenolpyruvate (PEP)
Aaron M. Hosios, Brian P. Fiske, Dan Y. Gui, Matthew G. Vander Heiden   +3 more
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PKM2 promotes reductive glutamine metabolism

Cancer Biology & Medicine, 2018
Pyruvate kinases M (PKM), including the PKM1 and PKM2 isoforms, are critical factors in glucose metabolism. PKM2 promotes aerobic glycolysis, a phenomenon known as " the Warburg effect". The purpose of this study was to identify the roles of PKM2 in regulating cellular metabolism.The CRISPR/Cas9 system was used to generate the PKM-knockout cell model ...
Miao Liu, Yuan‐Yuan Wang, Ruan Yuxia, Changsen Bai, Qiu Li, Cui Yanfen, Guoguang Ying, Binghui Li   +7 more
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High-Resolution Molecular-Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2). [PDF]

Chemistry
Producing more than 6 μs of cumulated simulation time with the AMOEBA polarizable force field, we determined key structural properties of the PKM2 (catalytic, FBP and TEPP) and PKM1 enzymes binding sites to determine new cryptic pockets for further antiviral/antitumoral drug design.
Delobelle Q, Inizan TJ, Adjoua O, Lagardère L, Célerse F, Maréchal V, Piquemal JP.   +6 more
europepmc   +2 more sources

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis [PDF]

Nature Communications, 2016
AbstractMany types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified.
Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang, Zhimin Lu   +8 more
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PKM2, a Central Point of Regulation in Cancer Metabolism [PDF]

International Journal of Cell Biology, 2013
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the ...
Nicholas Wong, Jason De Melo, Damu Tang
doaj   +4 more sources

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells [PDF]

Cancer Cell International, 2019
Background Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies.
Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He, Xinping Cao   +6 more
doaj   +4 more sources

Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion. [PDF]

FASEB J
Left: Supraphysiological fructose amplifies glucose‐induced insulin secretion (GIIS) through sweet taste receptor (STR)‐mediated PLCβ2 signaling in pancreatic β‐cells. Concurrently, the phosphorylation of fructose to fructose 1‐phosphate (F1P) occurs in conjunction with the conversion of ATP to ADP. Subsequently, F1P inhibits pyruvate kinase M2 (PKM2).
Murao N, Morikawa R, Seino Y, Shimomura K, Maejima Y, Ohno T, Yokoi N, Yamada Y, Suzuki A.   +8 more
europepmc   +2 more sources