Results 91 to 100 of about 14,270 (217)

PKM2 Expression and Elevated CD163 in Macrophage Synergistically Promote Osteosarcoma Progression

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the relation between PKM2 and related pathological features of osteosarcoma, to further explore the markers for predicting the prognosis of osteosarcoma patients.
TAN Wenfu, YANG Juntao, XIA Xue, XIANG Renkun, WANG Xiaoxu   +4 more
doaj   +1 more source

NMR‐based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages

International Journal of Cancer, Volume 156, Issue 8, Page 1644-1655, 15 April 2025.
What's new? Current screening tests for colorectal cancer (CRC) include colonoscopy and fecal occult blood test, both of which have significant drawbacks. Here, the authors tested NMR‐based metabolomic fingerprinting as a potential CRC screening technique.
Rongzhi Cai, LiXin Ke, Yan Zhao, Jiayun Zhao, Huanian Zhang, Peie Zheng, Lijing Xin, Changchun Ma, Yan Lin   +8 more
wiley   +1 more source

CircRNA-0013747 Promotes Mesangial Cell Proliferation in Immunoglobulin A Nephropathy through Modulation of the Warburg Effect

Journal of Physiological Investigation
Immunoglobulin A nephropathy (IgAN) is characterized by aberrant mesangial cell (MC) proliferation, which is a critical determinant of glomerular sclerosis and renal dysfunction.
Huimei Zou, Wenli Deng, Lifen Xu, Mingjun Shi, Lingling Liu, Lei Gong, Daolin Cui, Fan Zhang   +7 more
doaj   +1 more source

Tracing the Evolution of Sex Hormones and Receptor‐Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Prostate and bladder cancers activate genes and pathways similar to those in the developmental stage by aggregating and analyzing current data. In this process, sex hormones and their receptors maybe a key role in causing and reversing the “cold” and “hot” immune tumor phenotypes, potentially enhancing the immune response.
Dengxiong Li, Zhipeng Wang, Qingxin Yu, Jie Wang, Ruicheng Wu, Zhouting Tuo, Koo Han Yoo, Dilinaer Wusiman, Luxia Ye, Yiqing Guo, Yubo Yang, Fanglin Shao, Ziyu Shu, Uzoamaka Okoli, William C. Cho, Wuran Wei, Dechao Feng   +16 more
wiley   +1 more source

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways

Journal of Inflammation Research, 2021
Zhen-Hua Ying,1 Hui-Min Li,1 Wen-Ying Yu,2 Chen-Huan Yu2– 4 1Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310006, People’s Republic of China; 2Zhejiang Key Laboratory of Experimental Animal and Safety ...
Ying ZH, Li HM, Yu WY, Yu CH
doaj  

Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Pyruvate carboxylase (PC), as a catalytic enzyme located within the mitochondria, plays an important role in kidney fibrosis. PC deficiency reduces its interaction with sulfide:quinone oxidoreductase (SQOR), increasing the ubiquitination and degradation of SQOR.
Hao Huang, Yuanyuan Han, Yan Zhang, Jianhua Zeng, Xin He, Jiawei Cheng, Songkai Wang, Yiwei Xiong, Hongling Yin, Qiongjing Yuan, Ling Huang, Yanyun Xie, Jie Meng, Lijian Tao, Zhangzhe Peng   +14 more
wiley   +1 more source

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth [PDF]

, 2009
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae‐Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan L. Kaufman, Jing Chen   +19 more
openalex   +1 more source

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

Disruption of the eEF1A1/ARID3A/PKC‐δ Complex by Neferine Inhibits Macrophage Glycolytic Reprogramming in Atherosclerosis

Advanced Science, Volume 12, Issue 15, April 17, 2025.
The eEF1A1/ARID3A/PKC‐δ complex critically regulates macrophage glycolytic reprogramming in atherosclerosis by mediating ARID3A phosphorylation and nuclear translocation, thereby driving ENO2 transcriptional activation. Neferine targets eEF1A1 to disrupt the eEF1A1/ARID3A/PKC‐δ complex to inhibit ENO2‐mediated macrophage glycolytic reprogramming in ...
Baoping Xie, Li‐Wen Tian, Chenxu Liu, Jiahua Li, Xiaoyu Tian, Rong Zhang, Fan Zhang, Zhongqiu Liu, Yuanyuan Cheng   +8 more
wiley   +1 more source

Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities

European Journal of Immunology, Volume 55, Issue 4, April 2025.
Immune cells and stromal cells undergo metabolic reprogramming in both rheumatoid and osteoarthritis. This review summarises current evidence on the metabolic changes within and the crosstalk between immune and stromal cells in these diseases. In addition, we explore the therapeutic potential of targeting metabolic processes for the treatment of ...
Órlaith C. Henry, Luke A. J. O'Neill
wiley   +1 more source