Results 91 to 100 of about 22,457 (246)

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, EarlyView.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart

Physiological Reports
Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM).
Katie C. Y. Lee, Allison L. Williams, Akitoshi Hara, Vedbar S. Khadka, Jeffrey Hayashi, Ralph V. Shohet   +5 more
doaj   +1 more source

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

Cancer Cell International, 2019
Background Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies.
Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He, Xinping Cao   +6 more
doaj   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

Nature Communications
Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic ...
Rong-Hsuan Wang, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, Shao-Yun Lo, Zhong-Liang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen-Ling Chen, Yi-Hsuan Wu, Lily Hui-Ching Wang, Wen-Ching Wang, Shu-Yi Lin, Hsing-Jien Kung, Lu-Hai Wang, Hui-Chun Cheng, Kai-Ti Lin   +20 more
doaj   +1 more source

Pyruvate kinase M2 inhibits cisplatin induced caspase-dependent apoptosis via ERK-mediated signaling pathway in hepatocellular carcinoma cells [PDF]

, 2016
M2型丙酮酸激酶（pyruvatekinaseisoenzymetypeM2，PKM2）在肿瘤代谢 和生长等方面发挥重要作用。此外，PKM2还可作为蛋白激酶及辅助转录因子， 调控相关基因的转录表达，促进肿瘤细胞的增殖。我们实验室前期已经证实了 PKM2在肝细胞癌中高表达，并通过EGF/EGFR及TGFβ/TGFβR信号通路调控 肝癌细胞的迁移、侵袭。本课题研究目的在于进一步探索PKM2在肝癌细胞增 殖与凋亡方面的调控作用及相关分子生物学机制。 采用短发夹RNA转染HepG2和Huh7两株肝癌细胞株 ...
谌小春
core  

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]

, 2014
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Anastasiou, Dimitrios, Asara, John M., Auld, Douglas S., Austin, Christopher P., Boxer, Matthew B., Brimacombe, Kyle R., Cantley, Lewis C., Christofk, Heather R., Courtney, Kevin D., Dang, Lenny, Davidson, Shawn M., Dimov, Svetoslav, Fiske, Brian P., Harris, Marian H., Hong, Bum Soo, Inglese, James, Israelsen, William J., Jha, Abhishek, Jiang, Jian-kang, Jin, Shengfang, Johnson, Zachary R., Khan, Tahsin M., Kung, Charles, Kunii, Kaiko, Leister, William, Lunt, Sophia Y., Malstrom, Scott, Mattaini, Katherine R., Metallo, Christian M., Park, Hee-Won, Salituro, Francesco G., Shen, Min, Skoumbourdis, Amanda P., Southall, Noel, Stephanopoulos, Gregory, Tempel, Wolfram, Thomas, Craig J., Vander Heiden, Matthew G., Veith, Henrike, Walsh, Martin J., Yang, Hua, Yen, Katharine E., Yu, Yimin   +42 more
core   +1 more source

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer

Scientific Reports
One of the main characteristics of tumor metabolite reprogramming is enhanced glycolysis, and Pyruvate Kinase M2(PKM2) is a crucial enzyme that limits the pace of glycometabolism. Although PKM2 has been proven to affect the development of some cancers, a
Haosheng Zheng, Jian Tan, Fei Qin, Yuzhen Zheng, Xingping Yang, Zui Liu, Weijie Cai, Xianyu Qin, Hongying Liao   +8 more
doaj   +1 more source