Results 91 to 100 of about 18,059 (264)

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

Scientific Reports, 2018
Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood.
Farid Ahmad Siddiqui, Gopinath Prakasam, Shilpi Chattopadhyay, Asad Ur Rehman, Rayees Ahmad Padder, Mohammad Afaque Ansari, Rasha Irshad, Kailash Mangalhara, Rameshwar N. K. Bamezai, Mohammad Husain, Syed Mansoor Ali, Mohammad Askandar Iqbal   +11 more
doaj   +1 more source

PKM2–c-Myc–Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer

Frontiers in Pharmacology, 2020
The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism of PKM2 as a protein kinase regulating breast cancer progression and ...
Pian Yu, Pian Yu, Ao-xue Li, Ao-xue Li, Xi-sha Chen, Xi-sha Chen, Min Tian, Min Tian, Hai-yan Wang, Xin-luan Wang, Yi Zhang, Kuan-song Wang, Yan Cheng, Yan Cheng   +13 more
doaj   +1 more source

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Circulation Research, 2022
Background: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic coronary artery disease.
P. Doddapattar, Rishabh Dev, Madankumar Ghatge, Rakesh B. Patel, Manish Jain, N. Dhanesha, S. Lentz, Anil K. Chauhan   +7 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2

Journal of Hepatocellular Carcinoma, 2020
Tong Liu, 1–3,* Sainan Li, 2,* Liwei Wu, 2 Qiang Yu, 2, 4 Jingjing Li, 1 Jiao Feng, 2 Jie Zhang, 2, 4 Jiaojiao Chen, 2, 4 Yuting Zhou, 2, 4 Jie Ji, 2 Kan Chen, 2 Yuqing Mao, 5 Fan Wang, 6 Weiqi Dai, 7 Xiaoming Fan, 8 Jianye Wu, 1 Chuanyong Guo 1, 2
Liu T, Li S, Wu L, Yu Q, Li J, Feng J, Zhang J, Chen J, Zhou Y, Ji J, Chen K, Mao Y, Wang F, Dai W, Fan X, Wu J, Guo C   +16 more
doaj  

Tumor M2-PK: A novel urine marker of bladder cancer.

PLoS ONE, 2019
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer.
Weiya Liu, Benjamin L Woolbright, Karim Pirani, Ryan Didde, Erika Abbott, Gaurav Kaushik, Paige Martin, Jill Hamilton-Reeves, John A Taylor, Jeffrey M Holzbeierlein, Shrikant Anant, Eugene K Lee   +11 more
doaj   +1 more source

Tetramerization of PKM2 Alleviates Traumatic Brain Injury by Ameliorating Mitochondrial Damage in Microglia.

Journal of Neuroimmune Pharmacology
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Microglial activation and neuroinflammation are key cellular events that determine the outcome of TBI, especially neuronal and cognitive function.
Haiyan Zhu, Huiwen Zhang, Xiaojing Zhao, Lingyuan Zhang, Xue Liu, Zhi-Yuan Zhang, Yi-Zhi Ren, Yong Feng   +7 more
semanticscholar   +1 more source

PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling

Science Advances, 2022
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease, and the molecular mechanisms remain poorly understood. Our findings demonstrated that pyruvate kinase M2 (PKM2) promoted fibrosis progression by directly interacting with ...
Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qinge Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, X. Gu, Ting Xiao, Hui Huang, Shanshan Chen, W. Ning, Guang Yang, Cheng Yang, Honggang Zhou   +16 more
semanticscholar   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis

International Journal of Molecular Sciences, 2022
Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in the cure of colon cancer. Therefore, there is an urgent need to explore a safe and effective multidrug resistance reversal agent for colorectal cancer, which would
Haili Wu, Jin’e Du, Chenglu Li, Hanqing Li, Huiqin Guo, Zhuoyu Li   +5 more
semanticscholar   +1 more source