Results 101 to 110 of about 14,270 (217)

PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research

Diagnostic Pathology
Background Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contributing to ...
Xin Zhou, Yanshi Li, Min Pan, Tao Lu, Chuan Liu, Zhihai Wang, Fengxiang Tang, Guohua Hu   +7 more
doaj   +1 more source

MLN4924: additional activities beyond neddylation inhibition

Molecular & Cellular Oncology, 2019
MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj   +1 more source

Impact of butyrate on PKM2 and HSP90β expression in human colon tissues of different transformation stages: a comparison of gene and protein data [PDF]

, 2011
Franziska Jahns, Anne Wilhelm, Karl Otto Greulich, Henning Mothes, Mariya Y. Radeva, Anja Wölfert, Michael Glei   +6 more
openalex   +1 more source

Amelioration of signaling deficits underlying metabolic shortfall in TREM2R47H human iPSC‐derived microglia

The FEBS Journal, Volume 292, Issue 7, Page 1743-1762, April 2025.
The microglial receptor TREM2 is required for microglia responses in neurodegeneration, and the loss‐of‐function mutation R47H results in functional deficits linked to metabolism. Using human TREM2R47H or TREM2−/− microglia we show that supplementation with either citrate or succinate ameliorates microglia deficiencies due to TREM2 deficiency ...
Foteini Vasilopoulou, Thomas M. Piers, Jingzhang Wei, John Hardy, Jennifer M. Pocock   +4 more
wiley   +1 more source

The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase‐1/GSDMD Pathway in Neonatal Rats With Hypoxic‐Ischemic Brain Injury

Brain and Behavior
Introduction The presence of hypoxic‐ischemic brain damage (HIBD) in neonates triggers a strong neuroinflammatory reaction. Pyroptosis, a programmed cell death mechanism associated with inflammation, plays a crucial role in HIBD. Pyruvate kinase M2 (PKM2)
Sha Sha, Ni Jin, Ruiyu Zhou, Yanghao Ruan, Ying Ouyang   +4 more
doaj   +1 more source

Emerging roles of PKM2 in cell metabolism and cancer progression [PDF]

, 2012
Weibo Luo, Gregg L. Semenza
openalex   +1 more source

Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect [PDF]

, 2012
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaohong Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu   +9 more
openalex   +1 more source

The PKM2 activator TEPP‐46 suppresses cellular senescence in hydrogen peroxide‐induced proximal tubular cells and kidney fibrosis in CD‐1db/db mice

Journal of Diabetes Investigation, Volume 16, Issue 4, Page 598-607, April 2025.
PKM2 activator TEPP46 inhibited hydrogen peroxide‐induced cellular senescence in proximal tubular cells and suppressed kidney fibrosis in CD‐1 db/db mice with a trend toward suppression of certain senescence markers. But, hydrogen peroxide‐stimulated apoptosis and reduction in cell viability were both inhibited by TEPP46.
Shin‐ichiro Ishihara, Md. Imrul Kayes, Hirofumi Makino, Hiroaki Matsuda, Asako Kumagai, Yoshihiro Hayashi, Sara Amelia Ferdaus, Emi Kawakita, Daisuke Koya, Keizo Kanasaki   +9 more
wiley   +1 more source

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells [PDF]

, 2013
William J. Israelsen, Talya L. Dayton, Shawn M. Davidson, Brian P. Fiske, Aaron M. Hosios, Gary Bellinger, Jie Li, Yimin Yu, Mika Sasaki, James W. Horner, Laura N. Burga, Jianxin Xie, Michael J. Jurczak, Ronald A. DePinho, Clary B. Clish, Tyler Jacks, Richard G. Kibbey, Gerburg M. Wulf, Dolores Di Vizio, Gordon B. Mills, Lewis C. Cantley, Matthew G. Vander Heiden   +21 more
openalex   +1 more source

Controversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology

The FASEB Journal, Volume 39, Issue 6, 31 March 2025.
Multiple roles of Nur77. Nur77 has complex biological functions, including roles in the nervous system, genome integrity, cell differentiation, cell homeostasis, oxidative stress, autophagy, aging, and infection. Furthermore, Nur77 is implicated in various neurodegenerative diseases and cancers. Abstract Neuron‐derived clone 77 (Nur77), a member of the
Yanteng Wang, Na Li, Wenwei Guan, Difei Wang   +3 more
wiley   +1 more source