Results 101 to 110 of about 22,457 (246)

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice

Frontiers in Pharmacology
Introduction:Pyruvate kinase M2 (PKM2), the rate-limiting enzyme of glycolysis, plays a critical role in macrophage activation and a broad spectrum of chronic liver diseases.
Ziwei Kang, Ziwei Kang, Ruoyan Xie, Yiming Cui, Zhiwei Chen, Jincheng Li, Jinyu Lv, Weijia Ye, Peixin Zhao, Keke Zhang, Keke Zhang, Jian Hong, Jian Hong, Hengdong Qu, Hengdong Qu   +14 more
doaj   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, EarlyView.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Silencing of PKM2 promotes Fas-Dependent Apoptosis via P53 -Mediated in Gastric cancer Cells [PDF]

, 2015
背景和目的：PKM2作为丙酮酸激酶（pyruvatekinaseisoenzyme，PK）家族成员，在肿瘤中呈现高表达，并且在肿瘤能量代谢过程中起到关键作用。近期研究发现，PKM2还具备转录因子活性，参与调控细胞增殖与迁移侵袭，在恶性肿瘤的发生发展中发挥重要作用。我们研究发现，胃癌细胞株BGC823及AGS中基因沉默PKM2后，促进了顺铂诱导的细胞凋亡，由此表明PKM2可以减低胃癌细胞对化疗药物的敏感性，但具体机制有待探索 ...
宋俊娇
core  

Hormonal control of the metabolic machinery of hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide. It is an aggressive cancer with low cure rate, frequent metastasis, and highly resistant to conventional chemotherapies.
Ng, IOL, Wong, CCL, Wong, CM
core   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Insulin Resistance and Metabolic Hepatocarcinogenesis with Parent-of-Origin Effects in A×B Mice [PDF]

, 2011
Insulin resistance is a defining feature of metabolic syndrome and type 2 diabetes mellitus but also may occur independently of these conditions. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of these disorders, increases the risk ...
Connolly, Jessica, Fecteau, Michelle, Feng, Yan, Fox, James G, Hall, Gregory, Hartwell, Hadley J., Hashway, Sara A., Hines, Ian N., Rogers, Arlin B., Theve, Elizabeth J   +9 more
core   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Targeting pyruvate kinase M2 for the treatment of kidney disease

Frontiers in Pharmacology
Pyruvate kinase M2 (PKM2), a rate limiting enzyme in glycolysis, is a cellular regulator that has received extensive attention and regards as a metabolic regulator of cellular metabolism and energy.
Dan-Qian Chen, Jin Han, Jin Han, Hui Liu, Kai Feng, Ping Li   +5 more
doaj   +1 more source