Results 151 to 160 of about 24,140 (274)
Silencing of PKM2 promotes Fas-Dependent Apoptosis via P53 -Mediated in Gastric cancer Cells [PDF]
, 2015 背景和目的：PKM2作为丙酮酸激酶（pyruvatekinaseisoenzyme，PK）家族成员，在肿瘤中呈现高表达，并且在肿瘤能量代谢过程中起到关键作用。近期研究发现，PKM2还具备转录因子活性，参与调控细胞增殖与迁移侵袭，在恶性肿瘤的发生发展中发挥重要作用。我们研究发现，胃癌细胞株BGC823及AGS中基因沉默PKM2后，促进了顺铂诱导的细胞凋亡，由此表明PKM2可以减低胃癌细胞对化疗药物的敏感性，但具体机制有待探索 ...
宋俊娇
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Drug Design, Development and Therapy, 2020 Peng Gao,1,2 Shuo Shen,1,2 Xiaodong Li,3 Dandan Liu,1,2 Yuqing Meng,1,2 Yanqing Liu,1,2 Yongping Zhu,1,2 Junzhe Zhang,1,2 Piao Luo,1,2 Liwei Gu1,2 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People ...
Gao P +9 more
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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]
, 2015 Valeria Iansante +12 more
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Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell Glycolysis [PDF]
, 2016 Jiansheng Xie, Chunyan Dai, Xun Hu
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PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation [PDF]
, 2016 Min Xie +12 more
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MOESM1 of PKM2, function and expression and regulation
, 2019 Additional file 1: Table S1. PKM2 related GO terms and KEGG pathways in cancer tissue. GO terms and KEGG pathways with P-valuesâ <â 0.05 were considered statistically significant. GO: Gene Ontology. KEGG: Kyoto Encyclopedia of Genes and Genomes.
Zhang, Ze +5 more
openaire +1 more source