Results 151 to 160 of about 22,457 (246)

Advances in Tumor‐Derived Exosomal Non‐Coding RNAs Regulating M2 Macrophage Polarization: Molecular Mechanisms and Signaling Pathway

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Cancer persists as a leading cause of global mortality, largely due to the immunosuppressive tumor microenvironment (TME) that facilitates tumor progression and therapy resistance. M2 macrophages dominate this immunosuppressive landscape, and emerging evidence highlights tumor‐derived exosomes (TEXs) as critical mediators of ...
Yifan Bian, Jilei Li, Jiarui Cao, Sizhe Wang, Chunzheng Ma   +4 more
wiley   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng, Xu Zhang, Yulu Jiang, Yuxiang Luo, Zuao Wang, Xiaohong Du, Leifeng Chen   +6 more
wiley   +1 more source

Risk model of liquid–liquid phase separation‐related genes reveals the prognosis and tumor microenvironment characteristics of colorectal cancer

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
A prognostic framework for colorectal cancer based on liquid–liquid phase separation (LLPS) genes stratifies patients by survival and tumor microenvironment. The pivotal gene signature—encompassing ASXL1, DDX21, HNRNPA1L2, TACC3, and TRIM28—is functionally linked to epigenetic and splicing dysregulation, providing independent risk assessment and ...
Hui Liu, Ziwen Chen, Jie Hao, Ziyi Dong, Yaoyang Guo, Minghan Qiu, Xipeng Zhang, Ming Gao, Haiyang Zhang, Mingqing Zhang   +9 more
wiley   +1 more source

Recent Advances of In Situ Anticancer Nanomedicine from Enzyme‐Instructed Self‐Assembly

ChemNanoMat, Volume 11, Issue 12, December 2025.
This review summarizes advances in enzymatic self‐assemblies for generating in situ anticancer nanomedicine over the past five years. It highlights the unique features of enzyme substrates for in situ anticancer nanomedicine by discussing the representative examples.
Linrui Zou, Meihui Yi, Bing Xu
wiley   +1 more source

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Daji Guo, Mengjiao Cai, Yanmin Xian, Yinyin Chen, Yujun Feng, Chun Hu, Lizhang Zeng, Lei Shi, Shiqing Zhang   +8 more
wiley   +1 more source

Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Tumour metabolic reprogramming initiates a vicious cycle of immunosuppression and therapy resistance. This synergy disarms immunity and fortifies tumour cells, ultimately driving clonal evolution of resistant disease. Abstract Background Glucose metabolic reprogramming is a hallmark of cancer, best exemplified by the Warburg effect.
Li Ma, Ming‐yang Wu, Cui‐cui Tian, Hao‐ze Shi, Dan Song   +4 more
wiley   +1 more source

PFKFB3 drives hepatocellular carcinoma growth and radiotherapy resistance under matrix mechanical forces

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Abstract This commentary discusses the important study by Wang et al. on how tumor matrix stiffness drives radiotherapy resistance in hepatocellular carcinoma (HCC). The key breakthrough of this research lies in the discovery that the metabolic enzyme PFKFB3 undergoes nuclear translocation under mechanical stimulation and directly binds to the DNA ...
Haixia Gu, Ming Yang, Rishang Lu, Cheng Zhang   +3 more
wiley   +1 more source

Metabolic enzyme PFKFB3 mediates matrix stiffness‐potentiated tumour growth and radiotherapeutic resistance in HCC

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
This study proposes a stiffness‐triggered pathway that co‐opts PFKFB3 expression and localization to fuel HCC growth and compromise radiotherapy efficacy. Specifically, matrix stiffness suppresses PFKFB3 ubiquitination by downregulating E3 ubiquitin ligase NEDD4 expression, and then enhances the stablity of PFKFB3 protein to increase glycolysis ...
Mimi Wang, Jiajun Li, Jiali Qian, Xi Zhang, Miao Li, Yingying Zhao, Zhiming Wang, Kun Guo, Dongmei Gao, Yan Zhao, Rongxin Chen, Zhenggang Ren, Taiwei Sun, Fan Wang, Jiefeng Cui   +14 more
wiley   +1 more source

PKM2 regulates metabolic flux and oxidative stress in the murine heart

Physiological Reports
Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main isoform in ...
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet   +7 more
doaj   +1 more source