Results 141 to 150 of about 23,565 (226)

PKM2 aggregation drives metabolism reprograming during aging process

Nature Communications
AbstractWhile protein aggregation’s association with aging and age-related diseases is well-established, the specific proteins involved and whether dissolving them could alleviate aging remain unclear. Our research addresses this gap by uncovering the role of PKM2 aggregates in aging.
Juntao Bie, Ridong Li, Yutong Li, Chen Song, Zhaoming Chen, Tianzhuo Zhang, Zhiheng Tang, Li Su, Liangyi Zhu, Jiaxin Wang, You Wan, Jun Chen, Xiaoyun Liu, Tingting Li, Jianyuan Luo   +14 more
openaire   +3 more sources

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Pyruvate kinase M2 isozyme (PKM2) [PDF]

Science-Business eXchange, 2012
  +6 more sources

BMAL1 Drives Cisplatin Resistance in Non‐Small Cell Lung Cancer Via Lactate‐MRP1 Signaling Pathway

Thoracic Cancer, Volume 17, Issue 8, April 2026.
The drug cisplatin induces BMAL1 expression through AKT signaling in response to cisplatin‐induced oxidative stress. BMAL1 activates HIF‐1α‐mediated metabolic reprogramming and lactate production, which in turn activates the TAZ/c‐Jun/Snail complex to upregulate drug efflux pump MRP1, initiating and sustaining chemoresistance. ABSTRACT Lung cancer, the
Zixin Shi, Ziniu Qin, Chuantao Chen, Xiaolin Yang, Yunhan Hu, Xiaohui Meng, Yuxiang Cao, Xiang Tao, Zhijian Zhang, Tiancheng Xie, Huijun Wei, Zhihao Wu   +11 more
wiley   +1 more source

PKM2-mediated metabolic reprogramming of microglia in neuroinflammation

Cell Death Discovery
Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic enzyme, and its impact on microglial ...
Qi Zhang, Sha-Sha Wang, Zhao Zhang, Shi-Feng Chu   +3 more
openaire   +3 more sources

RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats

Aging Cell, Volume 25, Issue 4, April 2026.
RUVBL2 mediates stress granule aggregation by regulating microglial metabolic reprogramming, thereby exacerbating postoperative delirium in aged rats with mild cognitive impairment. ABSTRACT Postoperative delirium (POD) accelerates the transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) in elderly patients.
Lin Zhang, Zixuan Wang, Chenyi Yang, Xinyi Wang, Xing Liu, Haonan Zhang, Huan Liu, Huihui Liao, Jun Chen, Haiyun Wang   +9 more
wiley   +1 more source

Insulin enhances proliferation of hepatoma carcinoma cells by regulating the ubiquitination of glycolytic enzyme pyruvate kinase M2 [PDF]

, 2016
流行病学调查显示，胰岛素增加某些癌症的发病风险。胰岛素可作为一种生长因子促进细胞分裂；当体内有肿瘤细胞或突变细胞存在时，胰岛素可放大癌症的风险。但胰岛素对肿瘤细胞增殖调控的具体机制尚未明确。现有研究表明，丙酮酸激酶PKM2，在肿瘤中呈高表达，不仅是糖酵解限速酶，而且还具有转录因子活性，调控肿瘤细胞的增殖、迁移和侵袭过程，进而促进恶性肿瘤的发生发展。此外，核孤儿受体TR3能通过基因转录、蛋白质相互作用等参与细胞生长、自噬、增殖、凋亡、分化等生理过程，并且其功能发挥与亚细胞定位密切相关 ...
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The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research

Diagnostic Pathology
Background Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contributing to ...
Xin Zhou, Yanshi Li, Min Pan, Tao Lu, Chuan Liu, Zhihai Wang, Fengxiang Tang, Guohua Hu   +7 more
doaj   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

Cell Proliferation, Volume 59, Issue 4, April 2026.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang, Li Zhang, Zehao Feng, Xing Li, Zhaohui Qiu, Xingyun Wang, Lingmei Qian   +6 more
wiley   +1 more source