Results 151 to 160 of about 23,565 (226)

Emerging Therapeutic Strategies in Oral Cancer: Epigenetic, Mitochondrial and Immunotherapy Approaches

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer and poses treatment challenges owing to genetic, epigenetic and environmental factors. Conventional treatments, including surgery, chemotherapy and radiation therapy, often have limitations in terms of efficacy and tolerability.
Geetha Shanmugam, Carmelin Durai Singh, Rekha Thiruvengadam, Muthu Thiruvengadam, Vitaly Morozov, Roman Kolesnikov, Ali Alkaladi, Rashad Saleh, Mohammad Ali Shariati   +8 more
wiley   +1 more source

Pathogenesis of Adenomyosis: An Integrated Review of Cellular Origins, Molecular Mechanisms, and Intersecting Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework initiated by tissue injury and repair (TIAR), aberrant stem cell activation, or de novo metaplasia ...
Jiang Yang, Xiaochong Li, Yu Peng, Zhongfeng Sun, Lingli Zhang, Jie Duan, Nanbert Zhong   +6 more
wiley   +1 more source

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment

Biomolecules
The aberrant activation of glycolysis plays a pivotal role in the progression of liver diseases. Pyruvate kinase M2 (PKM2), one of the rate-limiting enzymes of glycolysis, not only regulates cellular metabolism but also translocates to the nucleus in its
Xiaoya Zhang, Danmei Zhang, Jin Guo, Chunxia Shi, Zuojiong Gong   +4 more
doaj   +1 more source

Täydelliset luvut [PDF]

, 2017
Tämän tutkielman tarkoituksena on tutustua täydellisiin lukuihin ja niiden ominaisuuksiin. Täydellisiin lukuihin liittyy matematiikan avoimia ongelmia, kuten parittomien täydellisten lukujen olemassaolo tai parillisten täydellisten lukujen lukumäärä ...
Niemistö, Katja
core  

PKM2 regulates metabolic flux and oxidative stress in the murine heart

Physiological Reports
Cardiac metabolism ensures a continuous ATP supply, primarily using fatty acids in a healthy state and favoring glucose in pathological conditions. Pyruvate kinase muscle (PKM) controls the final step of glycolysis, with PKM1 being the main isoform in ...
Katie C. Y. Lee, Allison L. Williams, Lu Wang, Guoxiang Xie, Wei Jia, Anastasia Fujimoto, Mariana Gerschenson, Ralph V. Shohet   +7 more
doaj   +1 more source

ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma. [PDF]

Cell Discov
Han L, Gan L, Schäfer B, Voss DM, Danielsen M, Kostov O, Liu J, Wang T, Caruthers MH, Chen H, Krainer AR.   +10 more
europepmc   +1 more source

Aqueous Extract of Rhubarb Promotes Hepatotoxicity via Facilitating PKM2-Mediated Aerobic Glycolysis in a Rat Model of Diethylnitrosamine-Induced Liver Cancer

Drug Design, Development and Therapy
Anni Zhao,1,* Xiaomei Liu,1,* Xiping Chen,1,* Sha Na,1,* Hui Wang,1 Xuan Peng,1 Peizhong Kong,1 Lu Li1,2 1Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese ...
Zhao A, Liu X, Chen X, Na S, Wang H, Peng X, Kong P, Li L   +7 more
doaj  

Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation. [PDF]

Int J Mol Sci
Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y.   +9 more
europepmc   +1 more source

Pyruvate kinase M2 isozyme (PKM2) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Quantitative Phosphoproteomics Identifies Myofibrillar Protein Phosphorylation Mediated by Pyruvate Kinase M2 in Beef. [PDF]

Foods
Xu Y, Liu X, Ren C, Hou C, Li X, Zhang D.   +5 more
europepmc   +1 more source