Results 171 to 180 of about 24,169 (302)

Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2. [PDF]

, 2014
Although insulin is known to regulate glucose metabolism and closely associate with liver cancer, the molecular mechanisms still remain to be elucidated.
Jiang, Bing-Hua, Jiang, Cheng-Fei, Li, Chong-Yong, Li, Qi, Liu, Ling-Zhi, Liu, Xue, Shen, Hua, Wang, Jing, Wang, Min, Yin, Yu, Zheng, Ji-Tai   +10 more
core   +4 more sources

Pyruvate Kinase Function Correlates With Red Blood Cell Properties and Clinical Manifestations in Sickle Cell Disease

American Journal of Hematology, Volume 100, Issue 5, Page 785-796, May 2025.
ABSTRACT Pyruvate kinase (PK) is a key enzyme involved in the final step of glycolysis, essential to produce adenosine triphosphate (ATP). Relatively decreased red blood cell (RBC) PK activity (reflected by a lower PK/hexokinase [HK] ratio) and PK thermostability (PK activity after exposure to heat) were recently identified as pathophysiological ...
M. J. M. Traets, J. F. Bos, S. van der Veen, L. van Pelt, M. J. van Dijk, B. A. van Oirschot, J. R. A. de Wilde, J. J. Jans, W. W. van Solinge, S. E. M. Schols, M. N. Lauw, M. H. Cnossen, E. Nur, B. J. Biemond, A. W. Rijneveld, E. J. van Beers, R. van Wijk, M. A. E. Rab   +17 more
wiley   +1 more source

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation [PDF]

, 2017
Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the growth of CGNP-derived ...
Farooq, Hamza, Fish, Taylor, Gershon, Timothy R., Green, Sarah C., Jones, Steven J.M., Li, Yisu, Liu, Hedi, Ma, Yussanne, Macdonald, Jeffrey M., Marra, Marco A., Meidinger, Jessica, Moore, Richard A., Morrissy, A. Sorana, Mungall, Andrew J., Taylor, Michael D., Tech, Katherine, Tikunov, Andrey P., Vander Heiden, Matthew G.   +17 more
core   +1 more source

The Roles of Exosomes in Anti‐Cancer Drugs

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Cancer is an escalating global health issue, with rising incidence rates annually. Chemotherapy, a primary cancer treatment, often exhibits low tumor‐targeting efficiency and severe side effects, limiting its effectiveness. Recent research indicates that exosomes, due to their immunogenicity and molecular delivery capabilities, hold
Panpan Feng, Xiaodong Zhang, Jian Gao, Lei Jiang, Yan Li   +4 more
wiley   +1 more source

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways

Journal of Inflammation Research, 2021
Zhen-Hua Ying,1 Hui-Min Li,1 Wen-Ying Yu,2 Chen-Huan Yu2– 4 1Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310006, People’s Republic of China; 2Zhejiang Key Laboratory of Experimental Animal and Safety ...
Ying ZH, Li HM, Yu WY, Yu CH
doaj  

Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease [PDF]

Graphical abstract Highlights Pyruvate kinase M2 is a predictor of clinical severity of coronary artery disease Pyruvate kinase M2 predicts the incidence of major adverse cardiovascular events Pyruvate kinase M2 showed additional prognostic value in ...
Huang, Yu, Ma, Hang-hao, Wu, Xue, Xu, Yi-wei, Zhang, Jing-kun, Zhang, Xin-tao, Zhao, Zi-wen   +6 more
core   +2 more sources

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth [PDF]

, 2009
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae‐Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan L. Kaufman, Jing Chen   +19 more
openalex   +1 more source

Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis

Journal of Extracellular Biology, Volume 4, Issue 5, May 2025.
ABSTRACT Extracellular vesicles (EVs) are small particles released by various cells, including cancer cells. They play a significant role in the development of different cancers, including brain metastasis. These EVs transport biomolecular materials such as RNA, DNA, and proteins from tumour cells to other cells, facilitating the spread of primary ...
Muhammad Izhar, Maciej S. Lesniak
wiley   +1 more source

The PKM2/HIF-1α Axis is Involved in the Pathogenesis of Endometriosis via TGF-β1 under Endometrial Polyps

Frontiers in Bioscience-Landmark
Background: Endometriosis patients exhibit a cancer-like glycolytic phenotype. The pyruvate kinase M2 (PKM2)/hypoxia-inducible factor-1 alpha (HIF-1α) axis plays important roles in glycolysis-related diseases, but its role in patients ...
Jianjuan Li, Li Liu, Ruiqi Fan
doaj   +1 more source

The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea, Mauro Siragusa, Ingrid Fleming   +2 more
wiley   +1 more source