Results 171 to 180 of about 22,457 (246)

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Pyruvate kinase M2 -mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome. [PDF]

Signal Transduct Target Ther
Yu C, Liu T, Wang Y, Guo X, Chen Y, Zhao Y, Liu X, Huang W, Zhao S, Mo J, Hu H, Lv P, Wang X, Yang Z, Pan J, Ding G, Sheng J, Liu X, Yang H, Huang HF.   +19 more
europepmc   +1 more source

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification. [PDF]

Noncoding RNA Res
Chen S, Xia H, Chen S.
europepmc   +1 more source

Senescent Fibroblasts Drive Melanoma Progression Through GCP‐2 Induced CREB Phosphorylation Enhancing Glycolysis

Aging Cell, Volume 24, Issue 12, December 2025.
Aging constitutes the largest risk factor for melanoma progression; the underlying reason is poorly understood. Here we show that the chemokine GCP‐2 is excessively released by senescent fibroblasts in vitro and in the skin of old melanoma patients. GCP‐2, via phosphorylation of the transcription factor CREB at serine 133, regulates cell cycle control ...
Abhijit Basu, Vida Farsam, Karmveer Singh, Diana Crisan, Nicolai Treiber, Lars Alexander Schneider, Margit Huber, Jennifer I. Engelmeyer, Björn Schumacher, Pallab Maity, Daniel Brandt, Martin Jastroch, Cornelia Mauch, Hartmut Geiger, Dimitris Kletsas, Karin Scharffetter‐Kochanek   +15 more
wiley   +1 more source

The LBX2-AS1-miR-491-5p-PKM2 Positive Feedback Loop Promotes Radiation Resistance of Esophageal Cancer by Enhancing Glycolysis. [PDF]

Biomed Res Int
Zhang F, Wang Z, Yao X, Zhang Q.
europepmc   +1 more source

Microbial and Metabolic Disorders in Cervical Cancer: Structural Insights, Biomarkers, Mechanisms, and Therapeutic Strategies

Cancer Science, Volume 116, Issue 12, Page 3228-3238, December 2025.
We unravel synergistic mechanisms by which microbial‐host metabolic networks regulate the tumor immune microenvironment and therapy resistance, bridging gaps between microbiota research and cancer metabolism. Identified biomarkers (e.g., Lactobacillus, C8‐ceramide‐1‐phosphate) and therapeutic approaches (e.g., FMT combined with immune checkpoint ...
Hong Tao, Luyu Wang, Yi Ding, Lixian Yi, Mutian Han, Mengmeng Gu, Jian Wu   +6 more
wiley   +1 more source

Effects of astrocytic PKM2 gene deletion on neuronal death following traumatic brain injury. [PDF]

Cell Death Discov
Kang BS, Park MK, Yang HW, Kim DY, Jung HH, Song A, Shin J, Son DS, Choi BY, Suh SW.   +9 more
europepmc   +1 more source

A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential. [PDF]

JCI Insight
Damen MS, Alarcon PC, Chan CC, Stankiewicz TE, Chung H, Sawada K, Ulanowicz CJ, Eom J, Oates JR, Wayland JL, Doll JR, Mukherjee R, Watanabe-Chailland M, Romick-Rosendale L, Szabo S, Helmrath MA, Sanchez-Gurmaches J, Moreno-Fernandez ME, Divanovic S.   +18 more
europepmc   +1 more source

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer [PDF]

, 2016
Aguilera Martínez, Óscar, Fernández Fraga, Mario, García Toraño, Estela, Muñoz Sagastibelza, M., Torrejón, Blanca   +4 more
core   +1 more source