Results 11 to 20 of about 18,059 (264)
PKM2 is not required for pancreatic ductal adenocarcinoma [PDF]
Cancer & Metabolism, 2018 Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models.
Alissandra L Hillis +6 more
doaj +6 more sources
Structural basis of PKM2 regulation [PDF]
Protein & Cell, 2015 Alterations in cell metabolism are a characteristic of many cancers. Cancer cells are metabolically rewired to support their rapid growth (Kim and Dang, 2006; Vander Heiden et al., 2009). The best-characterized metabolic phenotype observed in tumor cells is aerobic glycolysis, also known as the Warburg effect, which is a shift of ATP generation from ...
Weiwei Yang
openalex +4 more sources
Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells [PDF]
Cancer Cell International, 2019 Background Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies.
Yanzhu Lin +6 more
doaj +4 more sources
PKM2, a Central Point of Regulation in Cancer Metabolism [PDF]
International Journal of Cell Biology, 2013 Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the ...
Nicholas Wong, Jason De Melo, Damu Tang
doaj +4 more sources
PKM2 and the Tricky Balance of Growth and Energy in Cancer [PDF]
Molecular Cell, 2011 In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.
Andrew N. Macintyre, Jeffrey C. Rathmell
openalex +4 more sources
Lack of Evidence for PKM2 Protein Kinase Activity [PDF]
Molecular Cell, 2015 The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activity is lacking. Using [(32)P]-phosphoenolpyruvate (PEP)
Aaron M. Hosios +3 more
openalex +7 more sources
PKM2 promotes reductive glutamine metabolism
Cancer Biology & Medicine, 2018 Pyruvate kinases M (PKM), including the PKM1 and PKM2 isoforms, are critical factors in glucose metabolism. PKM2 promotes aerobic glycolysis, a phenomenon known as " the Warburg effect". The purpose of this study was to identify the roles of PKM2 in regulating cellular metabolism.The CRISPR/Cas9 system was used to generate the PKM-knockout cell model ...
Miao Liu +7 more
openalex +5 more sources
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis [PDF]
Nature Communications, 2016 AbstractMany types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified.
Ji Liang +8 more
openalex +5 more sources
The Role of PKM2 in Diabetic Microangiopathy
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022 Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of life of affected patients.
Chao Tu, Liangzhi Wang, Lan Wei
openaire +4 more sources
PKM2, function and expression and regulation [PDF]
Cell & Bioscience, 2019 Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has ...
Ze Zhang +5 more
openaire +4 more sources