Results 11 to 20 of about 14,270 (217)

RETRACTION: PCAT-1' s Role in Wound Healing Impairment: Mitochondrial Dysfunction and Bone Marrow Stem Cell Differentiation Inhibition via PKM2/β-Catenin Pathway and its Impact on Implant Osseo-Integration. [PDF]

Int Wound J
RETRACTION: T. Deng, Q. Liu, Y. Li, X. Zhu, Y. Long, B. Liu, J. Pang, and L. Zhao, “PCAT‐1′ s Role in Wound Healing Impairment: Mitochondrial Dysfunction and Bone Marrow Stem Cell Differentiation Inhibition via PKM2/β‐Catenin Pathway and its Impact on Implant Osseo‐Integration,” International Wound Journal 21, no.
europepmc   +2 more sources

PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la/ NF-κB induced neuroinflammation and mitochondrial damage. [PDF]

Sci Rep
This study aims to explore the effects and potential mechanisms of PKM2-mediated neuroinflammation leading to mitochondrial damage and its role in the progression of chronic fatigue syndrome (CFS).
Sun M, Zhang X, Feng X, Liang L.
europepmc   +2 more sources

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart. [PDF]

Physiol Rep
Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM).
Lee KCY, Williams AL, Hara A, Khadka VS, Hayashi J, Shohet RV.   +5 more
europepmc   +2 more sources

GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma. [PDF]

Cell Death Dis
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Abnormally high expression of Golgi protein 73 (GP73) and pyruvate kinase M2 (PKM2) is intimately associated with HCC progression. However, as secreted proteins, the role of their
Wang S, Zhang T, Zhou Y, Jiao Z, Lu K, Liu X, Jiang W, Yang Z, Li H, Zhang X.   +9 more
europepmc   +2 more sources

PKM2-mediated STAT3 phosphorylation promotes acute liver failure via regulating NLRP3-dependent pyroptosis. [PDF]

Commun Biol
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by high-grade inflammation and multi-organ failure. Our previous study shows that targeting the M2 isoform of pyruvate kinase (PKM2) to inhibit macrophage inflammation may be
Yu S, Pei S, Zhang M, Gao S, Chen J, Duan L, Hu E, Wang Y, Huang Y.   +8 more
europepmc   +2 more sources

Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]

PeerJ, 2020
Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang, Yingying Zhong, Jiecong Liang, Zhibin Li, Yun Ye   +4 more
doaj   +2 more sources

The Role of PKM2 in Diabetic Microangiopathy

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
Diabetic microangiopathy is among the most common complications affecting patients with diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD). Diabetic microangiopathy remains a persistent threat to the health and quality of life of affected patients.
Chao Tu, Liangzhi Wang, Lan Wei
openaire   +4 more sources

PKM2, function and expression and regulation [PDF]

Cell & Bioscience, 2019
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has ...
Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun, Fangfang Chen   +5 more
openaire   +4 more sources

USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2.

PLoS ONE, 2023
BackgroundThe pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect.
Yuanyuan Chen, Yunfei Guo, Mei Yuan, Song Guo, Shuaishuai Cui, Dahu Chen   +5 more
doaj   +1 more source

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein

Viruses, 2021
Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-
Seoung-Ae Lee, Charles Ho, Madison Troxler, Chin-Yo Lin, Sang-Hyuk Chung   +4 more
doaj   +1 more source