Results 11 to 20 of about 16,547 (202)

MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2

Archives of Medical Science, 2019
Introduction This study aims to explore the effects of microRNA-1286 (miR-1286) on the development of non-small cell lung cancer (NSCLC) via the aerobic glycolysis pathway by targeting pyruvate kinase muscle isozyme M2 (PKM2).
Hui Li, Xuexia Lin, Chaopeng Li, Jungai Li, Xunxun Xu, Dongyue Meng, Shushen Zheng   +6 more
doaj   +1 more source

Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model

Molecular & Cellular Oncology, 2018
Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target
Taku Sato, Mami Morita, Miyuki Nomura, Nobuhiro Tanuma   +3 more
doaj   +1 more source

Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. [PDF]

PLoS ONE, 2013
BACKGROUND AND AIMS: EGFR activation and PKM2 expression are instrumental in tumorigenesis. EGFR activation regulates PKM2 functions in a subcellular compartment-dependent manner and promotes gene transcription and tumor growth.
Le-Yi Wang, Yun-Peng Liu, Li-Gang Chen, Yan-Ling Chen, Li Tan, Jing-Jing Liu, Amarsanaa Jazag, Jian-Lin Ren, Bayasi Guleng   +8 more
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PKM2 is not required for colon cancer initiated by APC loss

Cancer & Metabolism, 2017
Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor
Allison N. Lau, William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, Omer H. Yilmaz, Dolores Di Vizio, Kenneth E. Hung, Matthew G. Vander Heiden   +10 more
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Role of pyruvate kinase M2 in oxidized LDL-induced macrophage foam cell formation and inflammation[S]

Journal of Lipid Research, 2020
Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in oxidized LDL (Ox-LDL)-induced macrophage foam cell formation and inflammation is unknown and therefore was studied. In
Amit Kumar, Priya Gupta, Minakshi Rana, Tulika Chandra, Madhu Dikshit, Manoj Kumar Barthwal   +5 more
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Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation

Frontiers in Immunology, 2021
Toll-like receptors (TLRs) play critical roles in regulating the abnormal activation of the immune cells resulting in the pathogenesis of inflammation and autoimmune diseases.
Xin Zhang, Xin Zhang, Yonghong Yang, Lina Jing, Weiwei Zhai, Hui Zhang, Qun Ma, Chunxia Li, Fenglian Yan, Dalei Cheng, Junfeng Zhang, Zhaochen Ning, Hui Shi, Changying Wang, Mingsheng Zhao, Jun Dai, Zhihua Li, Jiankuo Ming, Meimei Yu, Haiyan Wang, Hongyan Cheng, Huabao Xiong, Guanjun Dong   +22 more
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Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin

Cell Communication and Signaling, 2022
Background Acute kidney injury (AKI) is associated with a severe decline in kidney function caused by abnormalities within the podocytes' glomerular matrix. Recently, AKI has been linked to alterations in glycolysis and the activity of glycolytic enzymes,
Mohammed Alquraishi, Samah Chahed, Dina Alani, Dexter L. Puckett, Presley D. Dowker, Katelin Hubbard, Yi Zhao, Ji Yeon Kim, Laurentia Nodit, Huma Fatima, Dallas Donohoe, Brynn Voy, Winyoo Chowanadisai, Ahmed Bettaieb   +13 more
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PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

Frontiers in Oncology, 2022
PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba, Shigeo Ohba, Yongjian Tang, Yongjian Tang, Tor-Christian Aase Johannessen, Tor-Christian Aase Johannessen, Joydeep Mukherjee   +6 more
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Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer.

PLoS ONE, 2019
Pyruvate kinase M2 (PKM2) is an alternatively spliced variant, which mediates the conversion of glucose to lactate in cancer cells under normoxic conditions, known as the Warburg effect.
Akiko Suzuki, Sachin Puri, Pamela Leland, Ankit Puri, Tarsem Moudgil, Bernard A Fox, Raj K Puri, Bharat H Joshi   +7 more
doaj   +1 more source

PTDSS1 Drives Glycolysis and Malignant Progression of Lung Cancer Through Maintaining Nuclear–Mitochondrial Homeostatic Crosstalk

Frontiers in Bioscience-Landmark
Background: Phosphatidylserine synthase 1 (PTDSS1) is a crucial enzyme involved in phospholipid synthesis. However, its role in the metabolic regulation of lung cancer remains unclear.
Hailun Wang, Qiao Wang, Yandu He, Xuelu Pu, Yajun Li   +4 more
doaj   +1 more source