Results 241 to 250 of about 18,059 (264)

Natural product fargesin interferes with H3 histone lactylation via targeting PKM2 to inhibit non‐small cell lung cancer tumorigenesis

Biofactors, 2023
Non‐small cell lung cancer (NSCLC) is one of the most common malignant tumors. There is an urgent need to find more effective drugs that inhibit NSCLC. Fargesin (FGS) has demonstrated anti‐tumor effects; however, its efficacy and the molecular mechanism ...
Zizhang Guo, Yeqing Tang, Shunshun Wang, Yuming Huang, Qingjia Chi, Kang Xu, Lei Xue   +6 more
semanticscholar   +1 more source

Sarsasapogenin, a principal active component absorbed into blood of total saponins of Anemarrhena, attenuates proliferation and invasion in rheumatoid arthritis fibroblast‐like synoviocytes through downregulating PKM2 inhibited pathological glycolysis

Phytotherapy Research, 2023
Increased glycolytic in fibroblast‐like synoviocytes (FLS) of rheumatoid arthritis (RA) not only contributes to early‐stage disease pathogenesis but leads to sustained proliferation of FLS.
Yuan Dai, Panwang Liu, Wen Wen, Ping Li, Chen Yang, Ping Wang, Shijun Xu   +6 more
semanticscholar   +1 more source

Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2.

Journal of Medicinal Chemistry, 2023
Opioid addiction is a chronically relapsing disorder that causes critical public health problems. Currently, there is a lack of effective drug treatment.
Sha Jin, Cong Lin, Yibo Wang, Hongshuang Wang, X. Wen, P. Xiao, Xiaodong Li, Yinghua Peng, Jin-peng Sun, Yuyuan Lu, Xiaohui Wang   +10 more
semanticscholar   +1 more source

Activators of PKM2 in Cancer Metabolism

Future Medicinal Chemistry, 2014
Pyruvate kinase converts phosphoenolpyruvate to pyruvate, catalyzing the rate-limiting step of glycolysis. The M1 isoenzyme of pyruvate kinase (PKM1) is found in adult tissues; whereas, PKM2 is a splicesome variant found in embryonic and cancer cells.
Kent J. Carpenter, Steven L. Warner, David J. Bearss   +2 more
openaire   +2 more sources

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis

Acta Biochimica et Biophysica Sinica, 2023
Chondrocyte senescence is an important mechanism underlying osteoarthritis in the senile population and is characterized by reduced expressions of the extracellular matrix proteins.
Bohan Liu, Chenzhong Wang, Ziyu Weng, Yi Yang, Hong Zhao, Yueqi Zhang, Qinming Fei, Yi Shi, Chi Zhang   +8 more
semanticscholar   +1 more source

Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications.

Current Medicinal Chemistry, 2023
Metabolic reprogramming of cells, from the normal mode of glucose metabolism named glycolysis, is a pivotal characteristic of impending cancerous cells.
Peng Chen, L. Lou, B. Sharma, Mengchu Li, Cheng-Liang Xie, Fen Yang, Yihang Wu, Qicai Xiao, Liqian Gao   +8 more
semanticscholar   +1 more source

PKM2 contributes to cancer metabolism

Cancer Letters, 2015
Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aerobic glycolysis, tetrameric PKM2 promotes the flux of glucose ...
Damu Tang, Nicholas Wong, Diane Ojo, Judy Yan   +3 more
openaire   +3 more sources

PKM2, a potential target for regulating cancer

Gene, 2018
Aberrated glucose metabolism is a key future of cancer cells. Unlike normal cells, tumor cells favor glycolysis even in the presence of sufficient oxygen. Pyruvate kinase (PK), a key glucose metabolic enzyme, converts phosphoenolpyruvate (PEP) to pyruvate by transferring the high-energy phosphate group to adenosine diphosphate (ADP) to produce ...
Yu-huan Li, Xiao-feng Li, Jia-tao Liu, Hua Wang, Lu-lu Fan, Jun Li, Guo-ping Sun   +6 more
openaire   +3 more sources

PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer

EMBO Journal
Phosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation.
Yang Wang, H-S Shu, Yanzhao Qu, Xin Jin, Jia Liu, Wanting Peng, Lihua Wang, Miao Hao, Mingjie Xia, Zhexuan Zhao, Kejian Dong, Yao Di, Miaomiao Tian, Fengqi Hao, Chaoyi Xia, Wenxia Zhang, Xueqing Ba, Yunpeng Feng, Min Wei   +18 more
semanticscholar   +1 more source

PKM2 Is Essential for Bladder Cancer Growth and Maintenance

Cancer Research, 2021
Abstract Pyruvate kinase M2 (PKM2) has been shown to promote tumorigenesis by facilitating the Warburg effect and enhancing the activities of oncoproteins. However, this paradigm has recently been challenged by studies in which the absence of PKM2 failed to inhibit and instead accelerated ...
Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-Shong Tang, Tung-Tien Sun, Xue-Ru Wu   +7 more
openaire   +2 more sources