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Changes in PKM2 Associate with Prostate Cancer Progression
Cancer Investigation, 2014Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas.
Nicholas, Wong +5 more
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PKM2 is a Novel Osteoporosis-Associated Protein in Chinese
Endocrine ResearchPurpose:Osteoporosis is characterized by low bone mineral density (BMD) and high risk of osteoporotic fracture (OF). Peripheral blood monocytes (PBM) can differentiate into osteoclasts to resorb bone. This study was to identify PBM-expressed proteins significant for osteoporosis in Chinese Han elderly population (>65 years), and ...
Qing Xu +7 more
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PKM2-induced protection from hyperglycaemia
Nature Reviews Nephrology, 2022openaire +2 more sources
PKM2: A novel helmsman of lipid metabolism
Cellular SignallingZhijun Liu, Yifei Le, Dezhao Lu
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