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Tetrameric PKM2 Activation Curbs CD4+ T Cell Overactivation
Trends in Endocrinology & Metabolism, 2020Angiari et al. recently reported that TEPP-46 induces PKM2 tetramerization, thereby inhibiting its nuclear translocation and suppressing CD4+ T cell activation, T helper (Th)1/Th17 cell development, and experimental autoimmune encephalomyelitis (EAE) development both in vitro and in vivo. Moreover, TEPP-46 suppresses T cell glycolysis.
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PKM2-induced protection from hyperglycaemia
Nature Reviews Nephrology, 2022openaire +2 more sources
Pig gene mapping: PKM2-MPI-NP synteny
Cytogenetic and Genome Research, 1981Gellin, Joel +3 more
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