Results 211 to 220 of about 23,565 (226)

Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner

Cell Insight
Ronghui Gao, Qifang Li, Jiahao Guo, Zirou Peng, Chuan Gao, Zirui Zhou, Hankun Hu, Jing Zhang   +7 more
openaire   +1 more source

A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy. [PDF]

Cell Death Dis
Chen JY, Xue YT, Lin B, Huang XY, Lin F, Chen DN, Zhang WJ, Wei Y, Xue XY, Zheng QS, Ke ZB, Xu N.   +11 more
europepmc   +1 more source

Regulation of glycosylation in radiotherapy: exploring the multiple effects of DNA damage, immune response, stromal microenvironment and metabolism. [PDF]

Front Oncol
Cui W, Jiang M, Zhang R, Yu J, Chen D.
europepmc   +1 more source

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PKM2 Blood.pdf

2023
Key Points: 1. Platelet activation increases PKM2 dimer formation, which modulates platelet functions and arterial thrombosis. 2. PKM2 regulates PI3Kmediated Akt and GSK3 signaling.
Nayak, Manasa, Ghatge, Madankumar, Flora, Gagan D., Dhanesha, Nirav, Jain, Manish, Markan, Kathleen R., Potthoff, Matthew J., R. Lentz, Steven, Chauhan, Anil K.   +8 more
openaire   +1 more source

PKM2 contributes to cancer metabolism

Cancer Letters, 2015
Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aerobic glycolysis, tetrameric PKM2 promotes the flux of glucose ...
Nicholas, Wong, Diane, Ojo, Judy, Yan, Damu, Tang   +3 more
openaire   +2 more sources

Activators of PKM2 in Cancer Metabolism

Future Medicinal Chemistry, 2014
Pyruvate kinase converts phosphoenolpyruvate to pyruvate, catalyzing the rate-limiting step of glycolysis. The M1 isoenzyme of pyruvate kinase (PKM1) is found in adult tissues; whereas, PKM2 is a splicesome variant found in embryonic and cancer cells.
Steven L, Warner, Kent J, Carpenter, David J, Bearss   +2 more
openaire   +2 more sources

PKM2 promotes proinflammatory macrophage activation in ankylosing spondylitis

Journal of Leukocyte Biology, 2023
Abstract Macrophages play a critical role in ankylosing spondylitis by promoting autoimmune tissue inflammation through various effector functions. The inflammatory potential of macrophages is highly influenced by their metabolic environment.
Weizhen Weng, Yanli Zhang, Lian Gui, Jingrong Chen, Weihang Zhu, Zhenguo Liang, Zhongming Wu, Yao Liang, Jiewen Xie, Qiujing Wei, Zetao Liao, Jieruo Gu, Yunfeng Pan, Yutong Jiang   +13 more
openaire   +2 more sources

PKM2, a potential target for regulating cancer

Gene, 2018
Aberrated glucose metabolism is a key future of cancer cells. Unlike normal cells, tumor cells favor glycolysis even in the presence of sufficient oxygen. Pyruvate kinase (PK), a key glucose metabolic enzyme, converts phosphoenolpyruvate (PEP) to pyruvate by transferring the high-energy phosphate group to adenosine diphosphate (ADP) to produce ...
Yu-huan Li, Xiao-feng Li, Jia-tao Liu, Hua Wang, Lu-lu Fan, Jun Li, Guo-ping Sun   +6 more
openaire   +2 more sources

G9a inhibition induced PKM2 regulates autophagic responses

The International Journal of Biochemistry & Cell Biology, 2016
Epigenetic regulation by histone methyltransferase G9a is known to control autophagic responses. As the link between autophagy and metabolic homeostasis is widely accepted, we investigated whether G9a affects metabolic circuitries to affect autophagic response in glioma cells.
Fahim, Ahmad, Deobrat, Dixit, Shanker Datt, Joshi, Ellora, Sen   +3 more
openaire   +2 more sources