miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
core +1 more source
Hormonal control of the metabolic machinery of hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) is one of the most fatal malignancies worldwide. It is an aggressive cancer with low cure rate, frequent metastasis, and highly resistant to conventional chemotherapies.
Ng, IOL, Wong, CCL, Wong, CM
core +1 more source
MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients [PDF]
, 2020 Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream.
Dewhurst, T +3 more
core +2 more sources
Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells [PDF]
Cancer Cell International, 2019 Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human cervical cancer (CC) remains unknown.The expression of PKM2 in 94 patients with CC in the complete response (CR) and noncomplete response (nCR ...
Qianting He +6 more
openaire +4 more sources
Insulin Resistance and Metabolic Hepatocarcinogenesis with Parent-of-Origin Effects in A×B Mice [PDF]
, 2011 Insulin resistance is a defining feature of metabolic syndrome and type 2 diabetes mellitus but also may occur independently of these conditions. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of these disorders, increases the risk ...
Connolly, Jessica +9 more
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PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation [PDF]
Protein & Cell, 2019 A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear.
Jinbo Han +5 more
openaire +4 more sources
Pyruvate kinase M2 inhibits cisplatin induced caspase-dependent apoptosis via ERK-mediated signaling pathway in hepatocellular carcinoma cells [PDF]
, 2016 M2型丙酮酸激酶（pyruvatekinaseisoenzymetypeM2，PKM2）在肿瘤代谢 和生长等方面发挥重要作用。此外，PKM2还可作为蛋白激酶及辅助转录因子， 调控相关基因的转录表达，促进肿瘤细胞的增殖。我们实验室前期已经证实了 PKM2在肝细胞癌中高表达，并通过EGF/EGFR及TGFβ/TGFβR信号通路调控 肝癌细胞的迁移、侵袭。本课题研究目的在于进一步探索PKM2在肝癌细胞增 殖与凋亡方面的调控作用及相关分子生物学机制。 采用短发夹RNA转染HepG2和Huh7两株肝癌细胞株 ...
谌小春
core
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Proteomic profiling of high risk medulloblastoma reveals functional biology [PDF]
, 2015 Genomic characterization of medulloblastoma has improved molecular risk classification but struggles to define functional biological processes, particularly for the most aggressive subgroups.
Brown, Kristy J. +13 more
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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]
, 2014 Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Anastasiou, Dimitrios +42 more
core +1 more source