Results 51 to 60 of about 18,059 (264)
PKM2 functions as a histone kinase [PDF]
Cell Cycle, 2012 In the presence of oxygen, most differentiated cells generate the energy needed for cellular processes primarily by metabolizing glucose to carbon dioxide by oxidation of glycolytic pyruvate in the mitochondrial tricarboxylic acid cycle. When oxygen becomes limited, differentiated cells produce large amounts of lactate.
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Pharmaceutical Biology, 2023 Context Rheumatoid arthritis (RA) is an autoimmune disease with aberrant Th17 cell differentiation. Panax notoginseng (Burk.) F. H. Chen (Araliaceae) saponins (PNS) have an anti-inflammatory effect and can suppress Th17 cell differentiation. Objective To
M. Shen +8 more
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PKM2 is not required for colon cancer initiated by APC loss
Cancer & Metabolism, 2017 Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor
Allison N. Lau +10 more
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Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
Frontiers in Pharmacology, 2023 Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang +7 more
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Structural insight into mechanisms for dynamic regulation of PKM2 [PDF]
Protein & Cell, 2015 Pyruvate kinase isoform M2 (PKM2) converts phosphoenolpyruvate (PEP) to pyruvate and plays an important role in cancer metabolism. Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer.
Yanhui Xu +4 more
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HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells. [PDF]
PLoS ONE, 2014 Pyruvate kinase M2 (PKM2) is predominantly expressed in cancers, which is considered as a key regulator of the Warburg effect. In this study, HSP40 was identified as a novel binding partner of PKM2.
Liangqian Huang +4 more
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Journal of Integrative Neuroscience, 2023 Background: The purpose of this study was to investigate the potential involvement of pyruvate kinase M2 (PKM2), an enzyme acting as a rate-limiting enzyme in the final phase of glycolysis, in the regulation of glial activation and brain damage of ...
Xiao-Yi Xiong +8 more
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PKM2 dictates the poised chromatin state of PFKFB3 promoter to enhance breast cancer progression
NAR Cancer, 2023 The hypoxic milieu is a critical modulator of aerobic glycolysis, yet the regulatory mechanisms between the key glycolytic enzymes in hypoxic cancer cells are largely unchartered. In particular, the M2 isoform of pyruvate kinase (PKM2), the rate-limiting
Madhura R. Pandkar +9 more
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PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa [PDF]
Disease Markers, 2021 Retinitis pigmentosa (RP) is a major cause of blindness that is difficult to diagnose and treat. PKM2, a subtype of pyruvate kinase, is strongly associated with oxidative stress and is expressed in photoreceptors. We investigated whether PKM2 reduces photoreceptor cell apoptosis and evaluated possible antiapoptotic mechanisms in RP.
Peiwen Zhu +3 more
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陆军军医大学学报, 2023 Objective To explore the molecular mechanism of amifostine in relieving cisplatin nephrotoxicity. Methods CCK-8 assay was used to detect the inhibitory effect of amifostine on cisplatin cytotoxicity in HK-2 and primary renal proximal tubular epithelial ...
XUE Rong +4 more
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