Results 91 to 100 of about 60,739 (253)

Protein kinase R regulates pancreatic ductal adenocarcinoma progression by modulating the cell cycle via GADD45A

Scientific Reports
Protein kinase R (PKR) functions both as a promoter and inhibitor in various cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We investigated the role of PKR in PDAC.
Yuki Numata, Mitsuhito Koizumi, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Kaori Marui, Sho Ishikawa, Masahito Kokubu, Yusuke Okujima, Yoshiki Imamura, Teruki Miyake, Teru Kumagi, Yoichi Hiasa   +12 more
doaj   +1 more source

Novel role of PKR in inflammasome activation and HMGB1 release [PDF]

, 2014
The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA
Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Erlandsson-Harris, Helena, Hotamisligil, Gökhan S., Inouye, Karen, Kalb, Thomas, Li, Jianhua, Lu, Ben, Lundbäck, Peter, Nakamura, Takahisa, Olofsson, Peder S., Roth, Jesse, Tang, Yiting, Ting, Jenny P-Y, Tracey, Kevin J., Valdes-Ferrer, Sergio I, Wang, Haichao, Yang, Huan, Zou, Yongrui   +19 more
core   +1 more source

Protein Kinase R Restricts the Intracellular Survival of Mycobacterium tuberculosis by Promoting Selective Autophagy

Frontiers in Microbiology, 2021
Tuberculosis (TB) is a deadly infectious lung disease caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). The identification of macrophage signaling proteins exploited by Mtb during infection will enable the development of alternative ...
Robin Smyth, Stefania Berton, Nusrah Rajabalee, Therese Chan, Jim Sun, Jim Sun   +5 more
doaj   +1 more source

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Aging Cell, 2019
Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation.
M. Tible, François Mouton Liger, J. Schmitt, A. Giralt, Karim A Farid, S. Thomasseau, S. Gourmaud, C. Paquet, Laure Rondi Reig, E. Meurs, J. Girault, J. Hugon   +11 more
semanticscholar   +1 more source

dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication

Frontiers in Cellular and Infection Microbiology, 2017
Enterovirus 71 (EV-A71) causes hand, foot and mouth disease in young children and infants, but can also cause severe neurological complications or even death.
Yu-Hsiu Chang, Yu-Hsiu Chang, Kean Seng Lau, Rei-Lin Kuo, Rei-Lin Kuo, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng, Jim-Tong Horng   +9 more
doaj   +1 more source

Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

Journal of Innate Immunity, 2020
Double-stranded RNA dependent kinase R (PKR) is originally identified as an intracellular sensor of viral infection, but its role in bacterial infection remains largely unknown. Here we report that PKR was an important regulator of antibacterial immunity
Yanliang Yang, Lingli Xie, Yanjun Zhong, Xiaoli Zhong, Ran Meng, Qianqian Xue, Fang Liang, Kai Zhao, Yiting Tang   +8 more
doaj   +1 more source

PKR modulates abnormal brain signaling in experimental obesity. [PDF]

PLoS ONE, 2018
Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic inflammation and are obvious risk factors for Alzheimer's disease. Recent evidences concerning obesity and diabetes suggest that the metabolic inflammasome (
Mariko Taga, François Mouton-Liger, Malha Sadoune, Sarah Gourmaud, Jenny Norman, Marion Tible, Sylvie Thomasseau, Claire Paquet, James A R Nicoll, Delphine Boche, Jacques Hugon   +10 more
doaj   +1 more source

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Antioxidants, 2019
Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear.
Ching-Hou Ma, Chin-Hsien Wu, I. Jou, Y. Tu, C. Hung, Wan-Ching Chou, Yun-Ching Chang, Pei-Ling Hsieh, Kun-Ling Tsai   +8 more
semanticscholar   +1 more source

dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

Viruses, 2012
The double-stranded RNA-dependent protein kinase PKR plays multiple roles in cells, in response to different stress situations. As a member of the interferon (IFN)‑Stimulated Genes, PKR was initially recognized as an actor in the antiviral action of IFN,
Eliane F. Meurs, Stéphanie Dabo
doaj   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source