Results 121 to 130 of about 60,739 (253)
Corneal power modelling with OCT data – Thin and thick lens paraxial models versus raytracing
Acta Ophthalmologica, EarlyView.Abstract Background Evaluating keratometric power with Zeiss index (PKZ), paraxial thick cornea power (Gullstrand [PG]) and power referenced to the front (PFV) and back vertex plane (PBV) and raytracing power (PR), and modelling the deviation from PKZ with a multivariable linear prediction model.
Achim Langenbucher +4 more
wiley +1 more source
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
Nature CommunicationsThe innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases.
Sadeem Ahmad +15 more
doaj +1 more source
PLoS Pathogens, 2016 Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like most other viruses, must navigate through an intricate network of antiviral ...
H. Rabouw +10 more
semanticscholar +1 more source
Fine structure of the zeros of orthogonal polynomials, I. A tale of two pictures [PDF]
, 2006 Mhaskar-Saff found a kind of universal behavior for the bulk structure of the zeros of orthogonal polynomials for large n. Motivated by two plots, we look at the finer structure for the case of the Verblunsky coefficients and for what we call the BLS ...
Simon, Barry
core +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Frontiers in Genetics, 2019 A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation ...
Raymond Kaempfer +5 more
doaj +1 more source
Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival
Scientific Reports, 2018 Transactivation response element RNA-binding protein (TRBP or TARBP2) initially identified to play an important role in human immunodeficiency virus (HIV) replication also has emerged as a regulator of microRNA biogenesis.
E. Chukwurah, Rekha C. Patel
semanticscholar +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Clinical Trials in Central Venous Access Devices: An Evidence and Gap Map
Journal of Advanced Nursing, EarlyView.ABSTRACT Aims To systematically map the landscape of central venous access device research from 2014 to 2024, identifying critical gaps in evidence that may impact nursing practice and patient outcomes across the full device lifecycle from selection through to removal.
Mari Takashima +14 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source