Results 181 to 190 of about 30,951 (226)
The integrated stress response in pancreatic β-cell failure in diabetes: from molecular mechanisms to precision therapeutics. [PDF]
Front Endocrinol (Lausanne)Huang Y, Zeng Y, Zhong X, Li L.
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Stress Granules Buffers Inflammation by Restricting dsRNA-led Mitochondrial Fragmentation
Maharana S +12 more
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The Caspase-Generated Fragments of PKR Cooperate to Activate Full-Length PKR and Inhibit Translation [PDF]
Cell Death and Differentiation, 2007 We have studied the involvement of receptor interacting protein kinase-1 (RIP1) and dsRNA-activated protein kinase (PKR) in external dsRNA-induced apoptotic and necrotic cell death in Jurkat T cell lymphoma. Our results suggest that RIP1 plays an imported role in dsRNA-induced apoptosis and necrosis.
Nele Festjens +2 more
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International Journal of Biochemistry and Cell Biology, 1999 The double-stranded (ds) RNA-regulated serine/threonine protein kinase, PKR, is an interferon-inducible enzyme of widespread occurrence in mammalian cells. PKR is activated by dsRNA via a mechanism involving autophosphorylation. Once activated, the enzyme phosphorylates the alpha-subunit of protein synthesis initiation factor eIF2, thereby inhibiting ...
Rosemary Jagus, Glen N. Barber
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Proteins that interact with PKR
Biochimie, 1994The in vitro activities of recombinant gene products of the vaccinia virus E3L and K3L genes have been compared. These proteins are both potent inhibitors of the dsRNA activated protein kinase (PKR) as assayed in cell-free translation systems or with purified PKR. The two gene products function at similar molar concentrations.
R, Jagus, M M, Gray
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A role for PKR in hematologic malignancies
Journal of Cellular Physiology, 2010AbstractThe double‐stranded RNA‐dependent kinase PKR has been described for many years as strictly a pro‐apoptotic kinase. Recent data suggest that the main purpose of this kinase is damage control and repair following stress and, if all else fails, apoptosis.
Blalock WL +4 more
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Science Signaling, 2000
Double-stranded RNA (dsRNA) is detected by cells and triggers several different cellular responses. These pathways are important for controlling viral infections in the host and include stimulation of apoptosis to prevent spread of the virus, inhibition of protein synthesis to prevent viral replication, and induction of antiviral ...
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Double-stranded RNA (dsRNA) is detected by cells and triggers several different cellular responses. These pathways are important for controlling viral infections in the host and include stimulation of apoptosis to prevent spread of the virus, inhibition of protein synthesis to prevent viral replication, and induction of antiviral ...
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Science's STKE, 2001
The vital role of interferons (IFNs) as mediators of innate immunity is well established. It has recently become apparent that one of the pivotal proteins in mediating the antiviral activity of IFNs, the double-stranded RNA (dsRNA)-activated protein kinase (PKR), also functions as a signal transducer in the proinflammatory response to ...
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The vital role of interferons (IFNs) as mediators of innate immunity is well established. It has recently become apparent that one of the pivotal proteins in mediating the antiviral activity of IFNs, the double-stranded RNA (dsRNA)-activated protein kinase (PKR), also functions as a signal transducer in the proinflammatory response to ...
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Journal of Interferon & Cytokine Research, 1999
The interferon (IFN)-induced, double-stranded RNA (dsRNA)-activated human protein kinase (PKR) has been shown to exert antiviral and antiproliferative effects. Activation of the enzyme in mammalian cells results in protein synthesis inhibition and cell death by apoptosis. Previous studies on the structure-function relationship of PKR have been based on
C, Rivas, J, Gil, M, Esteban
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The interferon (IFN)-induced, double-stranded RNA (dsRNA)-activated human protein kinase (PKR) has been shown to exert antiviral and antiproliferative effects. Activation of the enzyme in mammalian cells results in protein synthesis inhibition and cell death by apoptosis. Previous studies on the structure-function relationship of PKR have been based on
C, Rivas, J, Gil, M, Esteban
openaire +2 more sources