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Inhibition of PKR by RNA and DNA viruses
Virus Research, 2006Interferons were the first of the anti-viral innate immune modulators to be characterized, initially characterized solely as anti-viral proteins [reviewed in Le Page, C., Genin, P., Baines, M.G., Hiscott, J., 2000. Inteferon activation and innate immunity. Rev. Immunogenet. 2, 374-386]. As we have progressed in our understanding of the interferons they
Jeffrey O, Langland +4 more
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PKR regulation by phosphorylation and antiviral activity of the PKR-ADAR1 axis
2021Protein kinase RNA-activated (PKR) and Double-stranded RNA-specific adenosine deaminase (ADAR1) are two double stranded RNA binding proteins, respectively involved in the antiviral response to viruses and in the metabolism of dsRNA molecules. PKR is a cellular protein kinase, that in response to dsRNA molecules generated during viral infections, gets ...
Michiels, Thomas, Cesaro, Teresa
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Science Signaling, 2011
A kinase involved in detecting viral RNA also enhances inhibitory neurotransmission in the brain.
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A kinase involved in detecting viral RNA also enhances inhibitory neurotransmission in the brain.
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Nuclear, not cytoplasmic, PKR maneuvers in AML
Blood, 2015In this issue of Blood, Cheng et al have identified a novel and previously unrecognized nuclear function of double-stranded RNA-activated protein kinase (PKR) in the pathogenesis of acute myeloid leukemia (AML). Increased PKR promotes genomic instability and is associated with inferior outcomes in both AML and a mouse model of myelodysplastic syndrome (
Motohiko, Oshima, Atsushi, Iwama
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[Cloning and expression of PKR gene and affinity purification of PKR interacting proteins].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012To clone and express protein kinase regulated by double-stranded RNA (PKR) gene, and to purify and isolate PKR interacting proteins.By using specific primers, PKR gene fragments tagged with HA and FLAG (FLAG-PKR-HA, and HA-PKR-FLAG) were amplified by PCR, and cloned into pSG5 vector. The recombinant plasmids were transfected into PKR knockdown (PKR(
Jiong, Xie +6 more
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PKRS: A Product Knowledge Retrieve System
2019In this demo paper, we present the Product Knowledge Retrieve System (PKRS), which can retrieve the large-scale product knowledge efficiently. The PKRS has three features. Firstly, PKRS can retrieve not only the objective knowledge (e.g. categories) but also the subjective knowledge (e.g. users’ opinion). Secondly, a learned mapping dictionary (LMD) is
Taoyi Huang +4 more
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Trends in Biochemical Sciences, 1995
The double-stranded RNA (dsRNA)-activated protein kinase, now called PKR, was first discovered by virtue of its ability to phosphorylate translation initiation factor eIF-2 and inhibit its activity. Recent studies have shown that expression of inactive mutants of PKR in cultured cells causes them to acquire characteristics typical of transformed cells.
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The double-stranded RNA (dsRNA)-activated protein kinase, now called PKR, was first discovered by virtue of its ability to phosphorylate translation initiation factor eIF-2 and inhibit its activity. Recent studies have shown that expression of inactive mutants of PKR in cultured cells causes them to acquire characteristics typical of transformed cells.
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The caspase-generated fragments of PKR cooperate to activate full length PKR and inhibit translation
2004info:eu-repo/semantics ...
Kalai, Michaël +3 more
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