Results 51 to 60 of about 60,739 (253)

The Economic Impact of Lower Extremity Amputations in Diabetics. a Retrospective Study From a Tertiary Care Hospital of Faisalabad, Pakistan [PDF]

, 2020
Background: Among the various complications of diabetes, lower-extremity amputation due to diabetic foot is a common problem. In Pakistan, 6-7% of patients with diabetes suffer from diabetic foot ulceration.
Ehsan, S. B. (Sumera), Labeeq, M. (Muhammad), Rehman, W. (Waleed), Tariq, M. A. (Muhammad), Tung, S. A. (Samra), Yar, M. A. (Muhammad)   +5 more
core  

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
C. D. Sadik, M. Bachmann, J. Pfeilschifter, H. Muhl, Busch, Will, Hoet, Lovgren, Hoffman, Casciola-Rosen, Biggiogera, Malmegrim, Dieker, Rosen, Hof, Vandivier, Bowie, Gantier, Schr  der, Matsumoto, Honda, Yoneyama, Schleimer, M  ller, Sexton, Monks, Dow, Colin, O'neill, Schreiber, Schafer, Taniguchi, Colonna, Tamura, Hemmi, M  hl, Reddy, Sioud, Degen, Sturchier, Gowen, Nagai, Pirher, Platanias, Grumbach, Yu, Chung, Krysko, King, Akbar, Vervoordeldonk, Nikolaus, Wirtz, Hemmer, Katakura, Sel, Fadok, Voll, Moller, O'Garra   +59 more
core   +1 more source

Intramolecular Charge‐Transfer Dopants Enable Isolated Triplet Excitons as Spin Qutrits in a Single Crystal

Angewandte Chemie, EarlyView.
Photoexcitation of an intramolecular charge‐transfer molecule doped into single crystals of a structurally similar host molecule results in well‐ordered, spectrally addressable, and orientation‐tunable triplet excitons that maintain coherence at elevated temperatures.
Yaoyao Han, Samuel B. Tyndall, Kathryn R. Peinkofer, Yuheng Huang, Ryan M. Young, Matthew D. Krzyaniak, Michael R. Wasielewski   +6 more
wiley   +2 more sources

Heparin Activates PKR by Inducing Dimerization [PDF]

Biophysical Journal, 2011
Protein kinase R (PKR) is an interferon-induced kinase that plays a pivotal role in the innate immunity pathway. PKR is activated to undergo autophosphorylation upon binding to double-stranded RNAs or RNAs that contain duplex regions. Activated PKR phosphorylates the α subunit of eukaryotic initiation factor 2, thereby inhibiting protein synthesis. PKR
Anderson, Eric, Pierre-Louis, Willythssa, Wong, C. Jason, Lary, Jeffrey W., Cole, James   +4 more
openaire   +3 more sources

Prokaryotic respiration and production in the meso- and bathypelagic realm of the eastern and western North Atlantic basin [PDF]

, 2006
We measured prokaryotic production and respiration in the major water masses of the North Atlantic down to a depth of,4,000 m by following the progression of the two branches of North Atlantic Deep Water (NADW) in the oceanic conveyor belt.
Aristegui, Javier, Herndl, Gerhard J., Lebaron, Philippe, Reinthaler, Thomas, Robinson, Carol, Van Aken, Hendrik, Veth, Cornelis, Williams, Peter J. le B.   +7 more
core   +2 more sources

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

Angewandte Chemie, EarlyView.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada, Julong Jiang, Yu Sato, Takashi Yamazaki, Satoshi Maeda, Ken Tanaka   +5 more
wiley   +2 more sources

Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

mBio, 2015
Stress granules (SGs) are dynamic cytoplasmic repositories containing translationally silenced mRNAs that assemble upon cellular stress. We recently reported that the SG nucleating protein G3BP1 promotes antiviral activity and is essential in double ...
Lucas C. Reineke, Nancy Kedersha, Martijn A. Langereis, Frank J. M. van Kuppeveld, Richard E. Lloyd   +4 more
doaj   +1 more source

PKR inhibitors suppress endoplasmic reticulum stress and subdue glucolipotoxicity-mediated impairment of insulin secretion in pancreatic beta cells

Turkish journal of biology = Turk biyoloji dergisi, 2020
Type 2 diabetes mellitus is characterized by insulin resistance and hypersecretion of insulin from the pancreas to compensate for decreased insulin sensitivity in the peripheral tissues.
A. Yalçin, Gülçin Şarkici, UK Kolaç
semanticscholar   +1 more source

pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain

Brain, Behavior, & Immunity - Health, 2023
We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial ...
Sehwan Kim, Chanchal Sharma, Minsang Shin, Hyung-Jun Kim, Jaekwang Kim, Sang Ryong Kim   +5 more
doaj   +1 more source

Cell fate determined by the activation balance between PKR and SPHK1

Cell Death and Differentiation, 2020
Double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) activation via autophosphorylation is the central cellular response to stress that promotes cell death or apoptosis.
Han Qiao, Tianqing Jiang, Peiqiang Mu, Xiaoxuan Chen, X. Wen, Zhangsheng Hu, Shulin Tang, Jikai Wen, Yiqun Deng   +8 more
semanticscholar   +1 more source