Results 61 to 70 of about 60,739 (253)

Mechanism of PKR Activation by dsRNA [PDF]

Journal of Molecular Biology, 2008
Protein kinase R (PKR) is a central component of the interferon antiviral defense pathway. Upon binding double-stranded RNA (dsRNA), PKR undergoes autophosphorylation reactions that activate the kinase. PKR then phosphorylates eukaryotic initiation factor 2alpha, thus inhibiting protein synthesis in virally infected cells.
Peter A, Lemaire, Eric, Anderson, Jeffrey, Lary, James L, Cole   +3 more
openaire   +2 more sources

An antiviral response directed by PKR phosphorylation of the RNA helicase A. [PDF]

PLoS Pathogens, 2009
The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 ...
Anthony J Sadler, Olivier Latchoumanin, David Hawkes, Johnson Mak, Bryan R G Williams   +4 more
doaj   +1 more source

PKR Activation in Neurodegenerative Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2004
Interferon-inducible, double-stranded RNA-dependent protein kinase PKR is well known as an early cellular responder to viral infection. Activation of PKR has been associated with a number of downstream cell stress and cell death events, including a generalized shutdown of protein translation, activation of caspase-8, participation in JNK and p38 MAPK ...
openaire   +2 more sources

PKR Activation Favors Infectious Pancreatic Necrosis Virus Replication in Infected Cells

Viruses, 2016
The double-stranded RNA-activated protein kinase R (PKR) is a Type I interferon (IFN) stimulated gene that has important biological and immunological functions.
Amr A.A. Gamil, Cheng Xu, Stephen Mutoloki, Øystein Evensen   +3 more
doaj   +1 more source

Deficient PKR in RAX/PKR Association Ameliorates Ethanol-Induced Neurotoxicity in the Developing Cerebellum [PDF]

The Cerebellum, 2015
Ethanol-induced neuronal loss is closely related to the pathogenesis of fetal alcohol spectrum disorders. The cerebellum is one of the brain areas that are most sensitive to ethanol. The mechanism underlying ethanol neurotoxicity remains unclear. Our previous in vitro studies have shown that the double-stranded RNA (dsRNA)-activated protein kinase (PKR)
Hui, Li, Jian, Chen, Yuanlin, Qi, Lu, Dai, Mingfang, Zhang, Jacqueline A, Frank, Jonathan W, Handshoe, Jiajun, Cui, Wenhua, Xu, Gang, Chen   +9 more
openaire   +2 more sources

Space Efficiency of Propositional Knowledge Representation Formalisms [PDF]

, 2000
We investigate the space efficiency of a Propositional Knowledge Representation (PKR) formalism. Intuitively, the space efficiency of a formalism F in representing a certain piece of knowledge A, is the size of the shortest formula of F that represents A.
Cadoli, M., Donini, F. M., Liberatore, P., Schaerf, M.   +3 more
core   +3 more sources

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. [PDF]

PLoS Pathogens, 2016
During millions of years of coevolution with their hosts, cytomegaloviruses (CMVs) have succeeded in adapting to overcome host-specific immune defenses, including the protein kinase R (PKR) pathway.
Kathryn S Carpentier, Nicolle M Esparo, Stephanie J Child, Adam P Geballe   +3 more
doaj   +1 more source

PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing

Science Signaling, 2019
Intracellular DNA provokes cytoplasmic cGAS condensation, which requires the helicase G3BP1 and the RNA-dependent kinase PKR. Stronger together Aberrant intracellular recognition of self-DNA is controlled by the spatial restriction of the DNA sensor cGAS.
Siqi Hu, Hong-Min Sun, Lijuan Yin, Jian Li, S. Mei, Fengwen Xu, Chao Wu, Xiaoman Liu, Fei Zhao, Di Zhang, Yu Huang, L. Ren, S. Cen, Jianwei Wang, C. Liang, Fei Guo   +15 more
semanticscholar   +1 more source

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii [PDF]

, 2019
Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic for several nutrients including arginine, tryptophan, and purines, which it must acquire from ...
Amin, Parth H., Augusto, Leonardo, Sullivan, William J., Wek, Ronald C.   +3 more
core   +2 more sources

Implication of protein kinase R Gene quantification in hepatitis C Virus Genotype 4 induced Hepatocarcinogenesis

Diagnostic Pathology, 2012
Background Protein kinase RNA (PKR-regulated) is a double-stranded RNA activated protein kinase whose expression is induced by interferon. The role of PKR in cell growth regulation is controversial, with some studies supporting a tumour suppressor ...
Mohamed Amal A, Nada Ola H, El Desouky Mohamed A   +2 more
doaj   +1 more source