Results 81 to 90 of about 60,739 (253)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.

PLoS Pathogens, 2016
Sensing invading pathogens early in infection is critical for establishing host defense. Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection.
Alissa M Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J Marié, David E Levy   +5 more
doaj   +1 more source

Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization. [PDF]

, 2018
Lentiviral vector mobilization following HIV-1 infection of vector-transduced cells poses biosafety risks to vector-treated patients and their communities.
Bi, Yanmin, Fry, Nate J, Hu, Peirong, Kafri, Tal, Kohn, Donald B, Ma, Hong, Suwanmanee, Thipparat, Zeithaml, Brian   +7 more
core  

Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]

, 2015
Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena, Esteban, Mariano, Nájera García, José Luis, Toribio, René, Ventoso, Iván   +4 more
core   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis

Journal of Virology
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli.
Daniel F. Edwards, III, Estela A. Pereira, Luiza A. Castro-Jorge, Juan M. Nevarez, Oded Foreman, Katherine R. Spindler   +5 more
doaj   +1 more source

Interaction of the Human Protein Kinase PKR with the Mouse PKR Homolog Occurs via the N-Terminal Region of PKR and Does Not Inactivate Autophosphorylation Activity of Mouse PKR

Virology, 1997
The RNA-dependent protein kinase (PKR) is implicated in the antiviral and antiproliferative actions of interferon. Mutant forms of human PKR display a transdominant behavior when expressed in transfected cells. The potential for the human PKR protein to physically interact with the mouse PKR homolog has therefore been examined.
Rende-Fournier, Rosanna, Ortega, Laura G., George, Cyril X., Samuel, Charles E.   +3 more
openaire   +2 more sources

The Economic Impacts of Inadequate Sanitation in Pakistan [PDF]

, 2013
This study conducts evidence based research to help advocacy in the sanitation sector. It aims to empirically estimate the economic impacts of current poor sanitation conditions in Pakistan as well as the economic benefits of options for improved ...

core  

Onkogene Signalwege bei der Infektion mit Adenoviren [PDF]

, 2005
Konditional replizierende Viren werden derzeit hinsichtlich ihrer Einsetzbarkeit in der Krebstherapie untersucht, mit dem Ziel der spezifischen, Virus-vermittelten Onkolyse.
Dobbelstein, Matthias (Prof. Dr.), Schümann, Michael   +1 more
core   +1 more source