Results 131 to 140 of about 39,920 (262)

Multisite Analysis of Vancomycin Concentration Predictions in a Bayesian Software in Adult and Pediatric Patients With and Without Acute Kidney Injury

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Bayesian software programs are recommended for area under the concentration‐time curve (AUC)‐guided vancomycin monitoring, but hesitancy remains for patients with acute kidney injury (AKI). Here, we assessed agreement between population pharmacokinetic model‐based Bayesian predictions and observed vancomycin concentrations in ...
Maria‐Stephanie A. Hughes, Jeffrey C. Pearson, Jasmine H. Hughes   +2 more
wiley   +1 more source

Evaluating the Impact of CYP1A2 Inhibition on the Pharmacokinetics of Savolitinib: A Phase 1 Open‐Label Study

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Savolitinib is an oral, potent, selective CNS‐penetrant MET‐tyrosine kinase inhibitor that in vitro studies indicate is metabolized by cytochrome P450 (CYP) enzymes, including CYP1A2, and by non‐CYP enzymes, such as aldehyde oxidase (AO). Savolitinib primary metabolites, M2 and M3, are formed mainly by CYP1A2 and AO, respectively. This Phase 1,
Kowser Miah, Jitendar Reddy, Pradeep Sharma, Ike Igwegbe, Simon Nelson, Caitlin Muldoon, Ronald Goldwater, Karthick Vishwanathan   +7 more
wiley   +1 more source

Chlorine Position Governs the Multitarget Bioactivity of Phenylhydrazines: In Vitro Antioxidant, Anti‐Inflammatory, Anti‐Tyrosinase and Antibacterial Evaluation Supported by DFT and Molecular Docking

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
Positional chlorination emerges as a key determinant of multitarget activity in phenylhydrazines. The para‐chloro derivative H3 shows the strongest anti‐inflammatory response, notable antibacterial activity, favorable ADMET behavior, and high COX‐2 affinity. DFT descriptors and molecular docking rationalize these substitution‐dependent effects, linking
L. Aouachria, S. Issadi, H. Debab, I. Selatnia, A.G. Soliman, K. Metwally, O. M. A. Khamaysa, Han‐seung Lee, Hassane Lgaz   +8 more
wiley   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Model‐Predicted Shear‐Wave‐Splitting Parameters in NE Japan: Comparison With Observations

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 10, October 2026.
Abstract We model olivine crystal preferred orientation (CPO) and shear wave splitting (SWS) in the mantle wedge, using the results of a 3‐D numerical thermomechanical model for the NE Japan subduction zone. The model predicts a quasi‐2‐D trench‐normal (E‐W) mantle wedge flow pattern beneath Tohoku, given the trench‐normal subduction, but a more ...
Lindsey M. Kenyon, Ikuko Wada, Junichi Nakajima, Naoki Uchida   +3 more
wiley   +1 more source

Seasonal and Spatial Variability of Silicon Cycle in Godavari Tidal River Zone

Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 10, October 2026.
Abstract Dam regulation of tropical monsoonal rivers enhances seasonal contrasts in the tidal river zone (TRZ) hydrology, altering the delivery of dissolved silicon (DSi) to the coastal ocean. Here, we identify the drivers of Si cycling in the Godavari TRZ and quantify their implications for Si delivery to the Bay of Bengal (BoB). We analyzed elemental
Sarath Pullyottum Kavil, Jean Riotte, Ramananda Chakrabarti, V. V. S. S. Sarma, Arnaud Dapoigny, Gilles Reverdin, Damien Cardinal   +6 more
wiley   +1 more source

Dilema PKS: suara dan syariah

Buku ini adalah tesis Burhanuddin Muhtadi di Australian National University, membahas fenomena PKS dari sudut pandang keilmuan, mulai dari asal-usulnya sebagai jamaah tarbiyah pada masa orde baru, pengaruh ideologis dari Ikhwanul Muslimin mesir ...
MUHTADI, Burhanuddin
core  

Polyketide synthase gene clusters in the ericoid mycorrhizal fungus <i>Oidiodendron maius</i>: genome-wide prediction, expression profiling, and functional characterization of knockout mutants. [PDF]

Front Plant Sci
Belmondo S, Daghino S, Miyauchi S, Chiapello M, Shelest E, Bortolot M, Kohler A, Jacob C, Perotto S, Martino E.   +9 more
europepmc   +1 more source

Global Three‐Dimensional Simulation of Magnetospheric Dynamics During the Extreme Geomagnetic Storm of 10–11 May 2024

Journal of Geophysical Research: Space Physics, Volume 131, Issue 10, October 2026.
Abstract This study presents a high‐resolution three‐dimensional global magnetohydrodynamic (MHD) simulation of the historic geomagnetic storm of 10–11 May 2024, using observational data for the ACE solar wind input. This extreme event was characterized by intense solar wind dynamic pressure (∼50 nPa) and exceptionally strong interplanetary magnetic ...
Kyung Sun Park
wiley   +1 more source

Comparative Genomics Reveals Extensive Biosynthetic Diversity and Lineage-Specific Metabolic Potential Across <i>Talaromyces</i> Species. [PDF]

J Fungi (Basel)
Chellappan BV, Al-Sheikh H.
europepmc   +1 more source