Results 141 to 150 of about 2,539 (164)

It Is Time to Consider the Lost Battle of Microdamaged Piezo2 in the Context of E. coli and Early-Onset Colorectal Cancer. [PDF]

Int J Mol Sci
Sonkodi B.
europepmc   +1 more source

Microbiomics: Novel Biomarkers of Colorectal Cancer Diagnosis and Prognosis. [PDF]

Diagnostics (Basel)
Yang L, Meng W, Yang T, Zhu Y, Wang Z.
europepmc   +1 more source

Intratumoural pks⁺Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome. [PDF]

EBioMedicine
Chu YL, Georgeson P, Clendenning M, Mahmood K, Walker R, Como J, Joseland S, Preston SG, Rice T, Lynch BM, Milne RL, Southey MC, Giles GG, Phipps AI, Hopper JL, Win AK, Rosty C, Macrae FA, Winship I, Jenkins MA, Buchanan DD, Joo JE.   +21 more
europepmc   +1 more source

DNA cross-link repair deficiency enhances human cell sensitivity to colibactin-induced genotoxicity. [PDF]

Genes Environ
Kawanishi M, Tsubohira O, Ueshima A, Hisatomi Y, Oda Y, Sato M, Miyoshi N, Mutoh M, Ishikawa H, Wakabayashi K, Yagi T, Watanabe K.   +11 more
europepmc   +1 more source

Escherichia coli strains with the capacity for long-term persistence in the bowel microbiota carry the potentially genotoxic pks island

Microbial Pathogenesis, 2012
The pks genomic island found in Escherichia coli strains of phylogenetic group B2 encodes colibactin, a polyketide-peptide genotoxin that causes DNA double-strand breaks. We investigated the relationship between carriage of the pks island and the capacity of E. coli strains to persist in the gut microbiota of 130 Swedish infants, who were followed from
Forough L Nowrouzian, Eric Oswald
exaly   +4 more sources

The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer

Trends in Microbiology, 2022
The structure and mode of action of colibactin with its potential involvement in cancer have been extensively studied but little is known about the intrinsic function of the biosynthetic gene cluster, coding for colibactin, as a bacterial genotoxin. Paradoxically, this pathogenicity island is also found in commensal and probiotic strains of Escherichia
Camille V Chagneau, Min Tang-Fichaux, Frédéric Auvray   +2 more
exaly   +5 more sources

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Nature, 2020
International audienceVarious species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations ...
Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber   +2 more
exaly   +5 more sources

PCR-assisted impedimetric biosensor for colibactin-encoding pks genomic island detection in E. coli samples [PDF]

Analytical and Bioanalytical Chemistry, 2021
A fast PCR-assisted impedimetric biosensor was developed for the selective detection of the clbN gene from the polyketide synthase (pks) genomic island in real Escherichia coli samples. This genomic island is responsible for the production of colibactin, a harmful genotoxin that has been associated with colorectal cancer.
Ramon Gomez-Moreno, Claudia Binder, Abel Baerga-Ortiz   +2 more
exaly   +3 more sources

Detection of pks Island mRNAs Using Toehold Sensors in Escherichia coli

Life, 2021
Synthetic biologists have applied the biomolecular engineering approaches toward the goal of novel biological devices and have shown progress in diverse areas of medicine and biotechnology.
Taeyang Heo, Jongmin Kim, Kim Jongmin
exaly   +1 more source

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Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

Organic Letters, 2015
Colibactin is a structurally uncharacterized, genotoxic natural product produced by commensal and pathogenic strains of E. coli that harbor the pks island. A new metabolite has been isolated from a pks(+) E. coli mutant missing an essential biosynthetic enzyme.
Carolyn A, Brotherton, Matthew, Wilson, Gary, Byrd, Emily P, Balskus   +3 more
openaire   +2 more sources