Results 101 to 110 of about 212,073 (195)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
The grieving process in children [PDF]
, 2018 Tugovanje je proces koji u životu doživi svaki čovjek. Dječje shvaćanje smrti sastoji se od pet ideja: univerzalnost (sva živa bića nekada moraju umrijeti), nepovratnost (umrla osoba ne može ponovno oživjeti), nefunkcionalnost (sve životne funkcije, koje
Kosić, Katarina
core +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Analiza stanja psihosocialnih tveganj na delovnih mestih v mikro, malih in srednje velikih podjetjih [PDF]
, 2013 Raziskava predstavlja kvantitativen del metodološkega pristopa večje raziskovalne študije v okviru katere so se izvajale tudi fokusne skupine in poglobljeni intervjuji.
Kralj, Ana, Simčič, Blaž
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PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
, 2018 Strah je jedna od četiri primarne emocije. Predstavlja urođeni obrambeni mehanizam kojim se osoba štiti od različitih potencijalnih opasnosti, a izražava se na fizičkoj, kognitivnoj i bihevioralnoj razini.
Šapina, Daniela
core +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
pot slovensko-francoskega komunista do kariere jugoslovanskega informbirojevskega funkcionarja [PDF]
, 2015 After the split between Stalin and Tito from June 1948 the only centre of the Yugoslav pro-Soviet movement was established abroad. "Cominformist" groups gained support and hospitality in the USSR and the countries of people\u27s democracy.
Vojtěchovský, Ondřej
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