Results 151 to 160 of about 17,689,950 (324)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

eLife
Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown.
Xiang Mou, Daoyun Ji
doaj   +1 more source

Place cells are nonrandomly clustered by field location in CA1 hippocampus. [PDF]

Hippocampus, 2023
Wirtshafter HS, Disterhoft JF.
europepmc   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Evidence of spatial periodic firing in the subiculum of mice

Frontiers in Neural Circuits
The subiculum is a critical node of the hippocampal formation, integrating multiple circuits—including thalamic inputs and afferents from CA1 and medial entorhinal cortex—and projecting broadly to cortical and subcortical targets. Yet its contribution to
P. Abad-Perez, P. Abad-Perez, P. Abad-Perez, G. Rigamonti, G. Rigamonti, G. Rigamonti, F. J. Molina-Paya, F. J. Molina-Paya, F. J. Molina-Paya, G. Cabral-Pereira, Miriam Esteve-Campello, R. Scott, V. Borrell, V. Borrell, L. Martínez-Otero, L. Martínez-Otero, A. Falco, J. R. Brotons-Mas, J. R. Brotons-Mas, J. R. Brotons-Mas   +19 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

eLife
Contextual fear conditioning (CFC) is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous opportunities to understand the neural ...
Seetha Krishnan, Can Dong, Heather Ratigan, Denisse Morales-Rodriguez, Chery Cherian, Mark Sheffield   +5 more
doaj   +1 more source

Enhanced Reactivation of Remapping Place Cells during Aversive Learning. [PDF]

J Neurosci, 2023
Ormond J, Serka SA, Johansen JP.
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Learning Spatiotemporal Properties of Hippocampal Place Cells. [PDF]

eNeuro, 2022
Lian Y, Burkitt AN.
europepmc   +1 more source