Results 151 to 160 of about 2,280,368 (270)

Protocol for remapping of place cells in disease mouse models. [PDF]

STAR Protoc, 2021
Jun H, Chavez J, Bramian A, Igarashi KM.
europepmc   +1 more source

Guerra interpolation for place cells

Pyramidal cells that emit spikes when the animal is at specific locations of the environment are known as "place cells": these neurons are thought to provide an internal representation of space via "cognitive maps". Here, we consider the Battaglia-Treves neural network model for cognitive map storage and reconstruction, instantiated with McCulloch &
Centonze, Martino Salomone, Treves, Alessandro, Agliari, Elena, Barra, Adriano   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Brain region-specific gain modulation of place cells by VIP neurons. [PDF]

Nat Commun
Lenkey N, Garvert AC, Neubrandt M, Kriener B, Vervaeke K.   +4 more
europepmc   +2 more sources

Tetrode recording of rat CA1 place cells in an observational spatial working memory task. [PDF]

STAR Protoc, 2022
Mou X, Suresh P, Ji D.
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The functional organization of excitatory synaptic input to place cells. [PDF]

Nat Commun, 2021
Adoff MD, Climer JR, Davoudi H, Marvin JS, Looger LL, Dombeck DA.   +5 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Place cells dynamically refine grid cell activities to reduce error accumulation during path integration in a continuous attractor model. [PDF]

Sci Rep, 2022
Fernandez-Leon JA, Uysal AK, Ji D.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source