Results 61 to 70 of about 16,525,519 (328)

CoBeL-RL: A neuroscience-oriented simulation framework for complex behavior and learning

Frontiers in Neuroinformatics, 2023
Reinforcement learning (RL) has become a popular paradigm for modeling animal behavior, analyzing neuronal representations, and studying their emergence during learning. This development has been fueled by advances in understanding the role of RL in both
Nicolas Diekmann, Nicolas Diekmann, Sandhiya Vijayabaskaran, Xiangshuai Zeng, Xiangshuai Zeng, David Kappel, Matheus Chaves Menezes, Sen Cheng   +7 more
doaj   +1 more source

The stimulus control of local enclosures and barriers over head direction and place cell spatial firing

Brain and Behavior, 2021
Objective Head direction cell and place cell spatially tuned firing is often anchored to salient visual landmarks on the periphery of a recording environment.
Anna E. Smith, Emma R. Wood, Paul A. Dudchenko   +2 more
doaj   +1 more source

Dynamic Hippocampal CA2 Responses to Contextual Spatial Novelty

Frontiers in Systems Neuroscience, 2022
Hippocampal place cells are functional units of spatial navigation and are present in all subregions: CA1, CA2, CA3, and CA4. Recent studies on CA2 have indicated its role in social and contextual memories, but its contribution to spatial novelty ...
Guncha Bhasin, Indrajith R. Nair
doaj   +1 more source

Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.

Neuron, 2019
Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these memories influenced CA1 place cell assemblies while reference memories were partially updated.
Haibing Xu, P. Baracskay, J. O’Neill, J. Csicsvari   +3 more
semanticscholar   +1 more source

LSD degrades hippocampal spatial representations and suppresses hippocampal-visual cortical interactions

Cell Reports, 2021
Summary: Lysergic acid diethylamide (LSD) produces hallucinations, which are perceptions uncoupled from the external environment. How LSD alters neuronal activities in vivo that underlie abnormal perceptions is unknown.
Carli Domenico, Daniel Haggerty, Xiang Mou, Daoyun Ji   +3 more
doaj   +1 more source

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling [PDF]

, 2009
CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation.
Lindquist, Jonathan, Strauss, Gudrun, Lindquist, Jonathan A., Arhel, Nathalie, Nathalie Arhel, Tobias L. Haas, Edward Felder, Fulda, Simone, Haas, Tobias L., Henning Walczak, Felder, Edward, Kirchhoff, Frank, Gudrun Strauss, Sabine Karl, Simone Fulda, Walczak, Henning, Karl, Sabine, Frank Kirchhoff, Klaus-Michael Debatin, Debatin, Klaus-Michael, Jonathan A. Lindquist, Haas, Tobias   +21 more
core   +1 more source

Recalibration of path integration in hippocampal place cells

Nature, 2018
Hippocampal place cells are spatially tuned neurons that serve as elements of a ‘cognitive map’ in the mammalian brain1. To detect the animal’s location, place cells are thought to rely upon two interacting mechanisms: sensing the position of the animal ...
Ravikrishnan P. Jayakumar, Manu S. Madhav, F. Savelli, H. T. Blair, N. Cowan, J. Knierim   +5 more
semanticscholar   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Unsupervised Detection of Cell-Assembly Sequences by Similarity-Based Clustering

Frontiers in Neuroinformatics, 2019
Neurons which fire in a fixed temporal pattern (i.e., “cell assemblies”) are hypothesized to be a fundamental unit of neural information processing. Several methods are available for the detection of cell assemblies without a time structure. However, the
Keita Watanabe, Keita Watanabe, Tatsuya Haga, Masami Tatsuno, David R. Euston, Tomoki Fukai, Tomoki Fukai, Tomoki Fukai   +7 more
doaj   +1 more source

Place cells are more strongly tied to landmarks in deep than in superficial CA1

Nature Communications, 2017
Environmental cues affect place cells responses, but whether this information is integrated versus segregated in distinct hippocampal cell populations is unclear.
T. Geiller, Mohammad Fattahi, June-Seek Choi, S. Royer   +3 more
semanticscholar   +1 more source