Results 41 to 50 of about 888,393 (367)
Current Issues in Pharmacy and Medical Sciences, 2021 The objective of this meta-analysis study was to evaluate the comparative efficacy of empagliflozin (25 mg) with placebo in the treatment and management of type 1 diabetes mellitus.
Gillani Syed Wasif +4 more
doaj +1 more source
Generalizing the intention-to-treat effect of an active control against placebo from historical placebo-controlled trials to an active-controlled trial: A case study of the efficacy of daily oral TDF/FTC in the HPTN 084 study [PDF]
arXiv, 2023 In many clinical settings, an active-controlled trial design (e.g., a non-inferiority or superiority design) is often used to compare an experimental medicine to an active control (e.g., an FDA-approved, standard therapy). One prominent example is a recent phase 3 efficacy trial, HIV Prevention Trials Network Study 084 (HPTN 084), comparing long-acting
arxiv
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.
New England Journal of Medicine, 2010 BACKGROUND Oral fingolimod, a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end points measured on magnetic resonance imaging (MRI), as compared with either ...
L. Kappos +10 more
semanticscholar +1 more source
Wakening Past Concepts without Past Data: Class-Incremental Learning from Online Placebos [PDF]
arXiv, 2023 Not forgetting old class knowledge is a key challenge for class-incremental learning (CIL) when the model continuously adapts to new classes. A common technique to address this is knowledge distillation (KD), which penalizes prediction inconsistencies between old and new models.
arxiv
Statistical significance revisited [PDF]
, 2021 Statistical significance measures the reliability of a result obtained from a random experiment. We investigate the number of repetitions needed for a statistical result to have a certain significance. In the first step, we consider binomially distributed variables in the example of medication testing with fixed placebo efficacy, asking how many ...
arxiv +1 more source
New England Journal of Medicine, 1991 BACKGROUND AND METHODS In the Cardiac Arrhythmia Suppression Trial, designed to test the hypothesis that suppression of ventricular ectopy after a myocardial infarction reduces the incidence of sudden death, patients in whom ventricular ectopy could be ...
D. Echt +11 more
semanticscholar +1 more source
Journal of Indian Society of Periodontology, 2020 Objectives: The purpose of the study was to evaluate and compare the clinical efficacy and the durability of propolis and Light-cured ormocer-based desensitizer (Admira Protect, Voco: Cuxhaven Germany) in the treatment of dentin hypersensitivity (DH ...
Snigdha Maity +2 more
doaj +1 more source
Depression and Anxiety, 2018 The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety‐related disorders based on randomized placebo‐controlled trials.
Joseph K. Carpenter +5 more
semanticscholar +1 more source
Hepatology, 2018 The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of CC chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis (LF).
S. Friedman +22 more
semanticscholar +1 more source
BMJ, 2008 Pittrof and Rubinstein make the important point that the “placebo effect” is actually an effect—people often do get better on placebo.1 However, most, if not all, of the evidence for placebo effects comes from studies where patients expected to have a reasonable chance (generally 0.5) of receiving the active treatment.
openaire +3 more sources