Results 41 to 50 of about 1,543,966 (410)

Deep Brain Stimulation for Chronic Facial Pain: An Individual Participant Data (IPD) Meta-Analysis

Brain Sciences, 2023
Despite available, advanced pharmacological and behavioral therapies, refractory chronic facial pain of different origins still poses a therapeutic challenge.
Hebatallah Qassim, Yining Zhao, Armin Ströbel, Martin Regensburger, Michael Buchfelder, Daniela Souza de Oliveira, Alessandro Del Vecchio, Thomas Kinfe   +7 more
doaj   +1 more source

DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study [PDF]

, 2011
The impact of dietary n-3 PUFA on behavioural outcomes has been widely researched; however, very little attention has been given to their impact on brain functioning in physiological terms.
Jackson, Philippa, Kennedy, David, Reay, Jonathon, Scholey, Andrew   +3 more
core   +1 more source

Error-related negativity and the misattribution of state-anxiety following errors: On the reproducibility of Inzlicht and Al-Khindi (2012)

Frontiers in Human Neuroscience, 2016
In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to
Carmen Cano Rodilla, André Beauducel, Anja Leue   +2 more
doaj   +1 more source

Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma : results from two phase 3, randomised, double-blind, placebo-controlled trials [PDF]

, 2020
BACKGROUND: Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients with uncontrolled severe asthma and ...
Adir, Yochai, Bernstein, Jonathan A, Brusselle, Guy, Castro, Mario, Garin, Margaret, Hickey, Lisa, Humbert, Marc, Jacobs, Joshua, Marsteller, Douglas A, Maspero, Jorge Fernando, McElhattan, Jennifer, Murphy, Kevin, Vanlandingham, Rebecca, Virchow, J Christian   +13 more
core   +1 more source

The effect of alcohol and placebo on post-error adjustments

Frontiers in Human Neuroscience, 2013
Several studies have shown detrimental effects of alcohol on post-error adjustments. In contrast to previous studies, which focused on only one aspect of post-error adaptive behavior, we compared the effect of alcohol and placebo on post-error slowing ...
Klaas eBombeke, Nathalie eSchouppe, Wout eDuthoo, Wim eNotebaert   +3 more
doaj   +1 more source

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes [PDF]

, 2016
Background The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. Methods In this double-blind trial, we randomly assigned patients with type 2 diabetes
Bergenstal, RM, Brown-Frandsen, K, Buse, JB, Daniels, GH, Kristensen, P, LEADER Steering Committee on behalf of the LEADER Trial Investigators, Mann, JF, Marso, SP, Nauck, MA, Nissen, SE, Pocock, S, Poulter, NR, Ravn, LS, Steinberg, WM, Stockner, M, Zinman, B   +15 more
core   +1 more source

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [PDF]

, 2020
Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the ...
Aldrich, Christina, Eisenberg, Howard M, Hayman, Erik G, He, Feng, Jain, Sonia, Okonkwo, David O, Pasternak, Ofer, Shenton, Martha E, Simard, J Marc   +8 more
core  

Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]

, 2011
Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT_2A receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg, A. G. Wade, A. McConnachie, Blier, Buntinx, C. B. Nemeroff, Celada, Demyttenaere, E. Buntinx, G. M. Crawford, Gillespie, Guy, L. Haazen, Landen, T. Schlaepfer   +14 more
core   +1 more source

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney ...
J. Rosenstock, V. Perkovic, O. Johansen, M. Cooper, S. Kahn, N. Marx, J. Alexander, M. Pencina, R. Toto, C. Wanner, B. Zinman, H. Woerle, David Baanstra, E. Pfarr, S. Schnaidt, T. Meinicke, J. George, M. von Eynatten, D. McGuire   +18 more
semanticscholar   +1 more source

Music-Induced Analgesia in Healthy Participants Is Associated With Expected Pain Levels but Not Opioid or Dopamine-Dependent Mechanisms

Frontiers in Pain Research, 2022
Music interventions accommodate the profound need for non-pharmacological pain treatment. The analgesic effect of listening to music has been widely demonstrated across studies. Yet, the specific mechanisms of action have still to be elucidated. Although
Sigrid Juhl Lunde, Peter Vuust, Peter Vuust, Eduardo A. Garza-Villarreal, Eduardo A. Garza-Villarreal, Irving Kirsch, Arne Møller, Arne Møller, Lene Vase   +8 more
doaj   +1 more source