Results 131 to 140 of about 728,357 (259)

Sentinel dosing: A proposed algorithm to guide decision making on which cohorts in early phase clinical pharmacology trials should use this approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this paper is to describe a proposal for an algorithm to guide decision making on which cohorts in early phase pharmacology trials should employ a sentinel approach, thereby standardising and harmonising practices, and improving decision making around sentinel dosing.
Jules A. A. C. Heuberger, Perry de Jongh, Ewoud‐Jan van Hoogdalem, Wim Tamminga, Pieter de Graeff, Geert Jan Groeneveld   +5 more
wiley   +1 more source

Myths and Truths about Placebo Effect in Rehabilitation for Musculoskeletal Pain. [PDF]

Adv Ther, 2021
Iolascon G, Moretti A.
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher, Shen Cheng, Curtis Johnston, Sebastian Härtter, Wojtyniak Jan‐Georg, Jan Marquard, Igor Tartakovsky, Lori M. B. Laffel   +7 more
wiley   +1 more source

The Placebo Effect in Chronic Thromboembolic Pulmonary Hypertension Trials: A Systematic Review and Meta-Analysis. [PDF]

Med Sci (Basel)
Caldeira D, Cazeiro DI, Plácido R, Ferreira F, Calé R, Pinto FJ.   +5 more
europepmc   +1 more source

Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. [PDF]

Int J Mol Sci, 2022
Ortega Á, Salazar J, Galban N, Rojas M, Ariza D, Chávez-Castillo M, Nava M, Riaño-Garzón ME, Díaz-Camargo EA, Medina-Ortiz O, Bermúdez V.   +10 more
europepmc   +1 more source

Pharmacology and relevant drug interactions of metamizole

British Journal of Clinical Pharmacology, EarlyView.
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman, Linda C. Hendriksen, Irma M. Rigter, Markus W. Hollmann   +3 more
wiley   +1 more source

Justice for Placebo: Placebo Effect in Clinical Trials and Everyday Practice. [PDF]

Medicines (Basel)
Knezevic NN, Sic A, Worobey S, Knezevic E.   +3 more
europepmc   +1 more source

[What can psychotherapy learn from the placebo effect?] [PDF]

Psychotherapeut (Berl), 2022
Rief W.
europepmc   +1 more source

Expert insight into the education of healthcare professionals on medication adherence

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Medication non‐adherence is a global health problem affecting patients with numerous medical conditions. Training healthcare professionals (HCPs) on managing the challenging issue of medication non‐adherence requires an evidence‐based approach.
Fatima Rezae, Stephen Carter, Rebekah Moles, Ayano Kelly   +3 more
wiley   +1 more source

Premovement activity in the corticospinal tract is amplified by the placebo effect: an active inference account. [PDF]

Soc Cogn Affect Neurosci
Emadi Andani M, Braga M, Da Dalt F, Piedimonte A, Carlino E, Fiorio M.   +5 more
europepmc   +1 more source