En este artículo se discute el sentido que debe tener la investigación como herramienta de aproximación a la realidad cotidiana y del papel del investigador como agente de cambio social.Neste artigo se discute o sentido que deve ter a investigação como ...
Johan Sebastián Lopera Valle
doaj
Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial [PDF]
OBJECTIVES: To determine whether thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical ...
Davidson, K.M.+6 more
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Confusing placebo effect with natural history in epilepsy: A big data approach
For unknown reasons, placebos reduce seizures in clinical trials in many patients. It is also unclear why some drugs showing statistical superiority to placebo in one trial may fail to do so in another.
D. Goldenholz+4 more
semanticscholar +1 more source
Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang+11 more
wiley +1 more source
The paper presents psychobiological mechanisms underlying the placebo effect, and research approaches to determining the effect of placebo on the outcome of treatment.
Mara Bresjanac
doaj
The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes [PDF]
Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defence against oral and respiratory tract infections.
Cheng-Shiun He+9 more
core +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan+16 more
wiley +1 more source
Causal diagrams, the placebo effect, and the expectation effect
Eyal Shahar,1 Doron J Shahar2 1Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, 2Department of Mathematics, College of Science, University of Arizona, Tucson, AZ, USA Abstract: Using causal diagrams, a formal ...
Shahar E, Shahar DJ
doaj
Non-Chemical Distant Cellular Interactions as a potential confounder of Cell Biology Experiments
Distant cells can communicate with each other through a variety of methods. Two such methods involve electrical and/or chemical mechanisms. Non-chemical, distant cellular interactions may be another method of communication that cells can use to modify ...
Ashkan eFarhadi
doaj +1 more source
Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]
This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core +1 more source