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The Placebo Effect

JAMA: The Journal of the American Medical Association, 1985
To the Editor.— Drs Kramer and Shapiro 1 give some valuable guidelines to improving the quality of research in their article, "Scientific Challenges in the Application of Randomized Trials," in the Nov 16, 1984, issue ofThe Journal. However, I'm afraid they perpetuate some of the misunderstandings concerning the nature of the placebo effect and its ...
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The Placebo Effect

Survey of Ophthalmology, 1999
Placebos have been traditionally regarded as deceptive therapies and have not been understood in the broader context of social symbols and of interpersonal factors that surround the healing process itself. Although the power of inert substances to heal is well recognized, the placebo effect also influences the outcome of conventional therapies.
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Placebos and the Placebo Effect in Drug Trials

2019
In this review, we explored different ways of controlling the placebo effects in clinical trials and described various factors that may increase/decrease the placebo effect in randomized placebo-controlled trials. These factors can be subdivided into four groups, and while not all factors are effective in every study and under all clinical conditions ...
Paul, Enck, Sibylle, Klosterhalfen
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Differences in placebo effects

Pharmacology Biochemistry and Behavior, 1977
Constant volume injections of water and saline were evaluated in terms of their effects upon locomotor activity in the rat. Both solutions produced an overall decrease in activity and were found to be nonequivalent in their effect.
W L, Isaac, W, Isaac
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Consistency of the placebo effect

Journal of Psychosomatic Research, 2008
The existence of reliable personality predictors of the placebo effect is controversial. For prediction to be possible, the response to placebo must be reliable. We tested the consistency of the placebo effect by assessing the response to four trials of placebo analgesic treatment.Two identical experimental pain stimuli were administered simultaneously
Ben, Whalley   +2 more
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Placebo Effects in Medicine

New England Journal of Medicine, 2015
Research has revealed placebo effects to be genuine biopsychosocial phenomena representing more than simply spontaneous remission or normal symptom fluctuations. How can this understanding be used to benefit patients?
Ted J, Kaptchuk, Franklin G, Miller
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Determinants of placebo effects

2020
Determinants of placebo effects and placebo response can be considered from multiple intrinsic and extrinsic perspectives. Intrinsic factors may influence the patient and the clinician/researcher. Patient expectations and previous experiences are considered two of the major intrinsic determinants of placebo response.
Sharlet, Anderson, Glenn T, Stebbins
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[Placebo and placebo effect].

Annales pharmaceutiques francaises, 2006
The word placebo appeared for the first time in an English medical dictionary in 1785. In French, it appeared much latter in 1958. This word defines an experimental tool used for rigourous evaluation of a specific effect of pharmacological treatment and the non specific effect of any therapy.
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[Placebo and placebo effects--a review].

Psychotherapie, Psychosomatik, medizinische Psychologie, 2002
Placebo controls in clinical trials are usually employed to filter out undesired, psychological or non-specific effects from "true" therapeutic effects. Although this is useful in the context of clinical trials for the purpose of proving pharmacological efficacy, it is misleading to generalize this strategy to therapy as a whole.
Harald, Walach, Catarina, Sadaghiani
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Treatment effects and placebo effects

BMJ, 2015
Researchers investigated the effectiveness of iron supplementation on reducing fatigue in non-anaemic women with unexplained fatigue. A double blind randomised placebo controlled trial was performed. In total, 144 women aged 18-55 years were recruited from an academic primary care centre and eight general practices in western Switzerland.
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