Results 41 to 50 of about 639,786 (193)

Placebo response in depression

Dialogues in Clinical Neuroscience, 2002
With its naturally fluctuating course, depression is a highly placebo-responsive condition: mean placebo response rates in antidepressant clinical trials are 30% to 40%. We review the history and terminology of placebo and the proposed mechanisms underlying the placebo response, including the physician-patient relationship and biological, sociocultural,
Shamsah B, Sonawalla, Jerrold F, Rosenbaum   +1 more
openaire   +3 more sources

Randomized controlled trial of adalimumab in patients with nonpsoriatic peripheral spondyloarthritis [PDF]

, 2015
Objective. To evaluate the efficacy and safety of adalimumab in patients with active nonpsoriatic peripheral spondyloarthritis (SpA). Methods. ABILITY-2 is an ongoing phase III, multicenter study of adalimumab treatment.
Karunaratne, P Mahinda, Mease, Philip, Pangan, Aileen L, Rahman, Proton, Sieper, Joachim, Van den Bosch, Filip   +5 more
core   +1 more source

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?

Health Psychology Report, 2019
An active placebo is a substance that produces side effects similar to an active ingredient while not producing the same intended therapeutic effect. The aim of this study is to review the literature on the hypothesis of the active placebo response as a ...
Wojciech Oronowicz-Jaśkowiak, Przemysław Bąbel   +1 more
doaj   +1 more source

Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials. [PDF]

PLoS Biology, 2016
Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned.
Pascal Tétreault, Ali Mansour, Etienne Vachon-Presseau, Thomas J Schnitzer, A Vania Apkarian, Marwan N Baliki   +5 more
doaj   +1 more source

Life-history and hormonal control of aggression in black redstarts: blocking testosterone does not decrease territorial aggression, but changes the emphasis of vocal behaviours during simulated territorial intrusions [PDF]

, 2013
Introduction: Many studies in behavioural endocrinology attempt to link territorial aggression with testosterone, but the exact relationship between testosterone and territorial behaviour is still unclear and may depend on the ecology of a species.
Apfelbeck, Beate, Goymann, Wolfgang, Kiefer, Sarah, Kipper, Silke, Mortega, Kim G   +4 more
core   +2 more sources

Chlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials [PDF]

, 2005
BACKGROUND: Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated.
A George Awad, AO Odejide, B Thornley, Ben Thornley, CE Adams, Clive Elliott Adams, DG Altman, DK Wysowski, F Letemendia, FR Hine, G Norquist, JE Overall, Jo Borrill, JO Cole, JO Cole, John Rathbone, KF Schulz, Kristian Wahlbeck, L Tetreault, M Clark, M Clarke, M Egger, Mike Clarke, ML Clark, MY Chong, P Grygier, P Payne, R DerSimonian, R Prien, RA Hall, RJ Cook, RW Reschke, S Burgess, WT Hamill   +33 more
core   +3 more sources

Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. [PDF]

, 2017
A single dose of the apolipoprotein (apo)A-I mimetic peptide D-4F rendered high-density lipoprotein (HDL) less inflammatory, motivating the first multiple-dose study. We aimed to assess safety/tolerability, pharmacokinetics, and pharmacodynamics of daily,
Bloedon, LeAnne T., Duffy, Danielle, Dunbar, Richard L., Fogelman, Alan M., Movva, Rajesh, Navab, Mohamad, Norris, Robert B., Rader, Daniel J.   +7 more
core   +2 more sources

Does the rising placebo response impact antihypertensive clinical trial outcomes? An analysis of data from the Food and Drug Administration 1990-2016. [PDF]

PLoS ONE, 2018
Recent studies show that placebo response has grown significantly over time in clinical trials for antidepressants, ADHD medications, antiepileptics, and antidiabetics.
Arif Khan, Kaysee Fahl Mar, Joshua Schilling, Walter A Brown   +3 more
doaj   +1 more source

Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]

, 2019
Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H, Domanchuk, Kathryn, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Li, Lingyu, McDermott, Mary M, Polonsky, Tamar S, Stein, James, Taylor, Doris A, Tian, Lu, Zhao, Lihui   +11 more
core   +1 more source

DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study [PDF]

, 2011
The impact of dietary n-3 PUFA on behavioural outcomes has been widely researched; however, very little attention has been given to their impact on brain functioning in physiological terms.
Jackson, Philippa, Kennedy, David, Reay, Jonathon, Scholey, Andrew   +3 more
core   +1 more source