Results 41 to 50 of about 8,509,826 (346)

Commentary: analyzing binary data using MCPMod when zero counts are expected [PDF]

arXiv, 2022
Bretz et al (2005) proposed multiple Comparison Procedure and Modeling (MCPMod) method to design and analyze dose-finding study. Pinheiro (2014) then generalized it to various types of endpoint, including but not limited to binary endpoint, survival endpoint, count data, and longitudinal data. Pinheiro (2013) recommended to use the estimated covariance
arxiv  

Placebo Responses and Placebo Effects in Functional Gastrointestinal Disorders [PDF]

Frontiers in Psychiatry, 2020
Much has been written about the placebo effects in functional gastrointestinal disorders (FGD), especially in irritable bowel syndrome (IBS), driven by the early hypothesis that in randomized controlled trials (RCTs) of IBS, the placebo effect might be specifically high and thus, corrupts the efficacy of novel drugs developed for this condition.
Enck, Paul, Klosterhalfen, Sibylle
openaire   +5 more sources

Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study

Psychological Medicine, 2018
Background Major depressive disorder (MDD) is a highly heterogeneous condition in terms of symptom presentation and, likely, underlying pathophysiology. Accordingly, it is possible that only certain individuals with MDD are well-suited to antidepressants.
Christian A. Webb, M. Trivedi, Z. Cohen, D. Dillon, J. Fournier, F. Goer, M. Fava, P. McGrath, M. Weissman, R. Parsey, P. Adams, Joseph M. Trombello, Crystal M. Cooper, P. Deldin, M. Oquendo, M. McInnis, Q. Huys, G. Bruder, B. Kurian, M. Jha, R. DeRubeis, D. Pizzagalli   +21 more
semanticscholar   +1 more source

A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia

AGING MEDICINE, Volume 5, Issue 4, Page 246-256, December 2022., 2022
A 16‐week randomized double‐blind, placebo‐controlled trial for vascular dementia was carried out with WeiNaoKang (or SaiLuoTong). There were significant differences in improvement in cognitive function and activities of daily living, favouring the treatment group.
Junguang Liu, Dennis Chang, Dennis Cordato, Kien Lee, Hugh Dixson, Alan Bensoussan, Daniel Kam Yin Chan   +6 more
wiley   +1 more source

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?

Health Psychology Report, 2019
An active placebo is a substance that produces side effects similar to an active ingredient while not producing the same intended therapeutic effect. The aim of this study is to review the literature on the hypothesis of the active placebo response as a ...
Wojciech Oronowicz-Jaśkowiak, Przemysław Bąbel   +1 more
doaj   +1 more source

Accurate pain reporting training diminishes the placebo response: Results from a randomised, double-blind, crossover trial

PLoS ONE, 2018
Analgesic trials frequently fail to demonstrate efficacy of drugs known to be efficacious. Poor pain reporting accuracy is a possible source for this low essay-sensitivity.
R. Treister, O. Lawal, Jonathan D Shecter, Nevil Khurana, J. Bothmer, M. J. Field, S. Harte, G. Kruger, Nathaniel Katz   +8 more
semanticscholar   +1 more source

When Your Doctor “Gets It” and “Gets You”: The Critical Role of Competence and Warmth in the Patient–Provider Interaction

Frontiers in Psychiatry, 2019
Background: Research demonstrates that the placebo effect can influence the effectiveness of medical treatments and accounts for a significant proportion of healing in many conditions. However, providers may differ in the degree to which they consciously
Lauren C. Howe, Kari A. Leibowitz, Alia J. Crum   +2 more
doaj   +1 more source

Perioperative optimization of Crohn's disease

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 10-26, January 2023., 2023
Most Crohn's disease patients require surgery during the course of their illness, especially those who experience complications. The management of perioperative medications and surgery‐related decision‐making should be individualized and patient‐centered based on a multidisciplinary approach.
Chun‐Chi Lin, Hung‐Hsin Lin, Hui‐Chuen Chen, Nai‐Chia Chen, I‐Lun Shih, Ji‐Shiang Hung, Te‐Cheng Yueh, Feng‐Fan Chiang, Ping‐Wei Lin, Yuan‐Yao Tsai, Shu‐Chen Wei   +10 more
wiley   +1 more source

Placebo and the law of identification

Frontiers in Psychiatry
Thousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were ...
Steve F. Bierman, Andrew Weil, Stephen Dahmer   +2 more
doaj   +1 more source

Placebo response rates and potential modifiers in double-blind randomized controlled trials of second and newer generation antidepressants for major depressive disorder in children and adolescents: a systematic review and meta-regression analysis

European Child and Adolescent Psychiatry, 2018
Children and adolescents with major depressive disorder (MDD) appear to be more responsive to placebo than adults in randomized placebo-controlled trials (RCTs) of second and newer generation antidepressants (SNG-AD).
Ramona Meister, Maria Abbas, J. Antel, Triinu Peters, Yiqi Pan, U. Bingel, Y. Nestoriuc, J. Hebebrand   +7 more
semanticscholar   +1 more source