Results 51 to 60 of about 639,786 (193)

Possible Strategies to Mitigate Placebo or Vehicle Response in Dry Eye Disease Trials: A Narrative Review

Ophthalmology and Therapy, 2023
Many candidate drugs for dry eye disease (DED) have been assessed over the years in pursuit of demonstrating efficacy in both signs and symptoms. However, patients with DED have very limited treatment options for management of both signs and symptoms of ...
Michela Montecchi-Palmer, Min Wu, Maurizio Rolando, Charis Lau, Victor L. Perez Quinones, Reza Dana   +5 more
doaj   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C., Harazny, J., Hilgers, K.F., Michelson, G., Oehmer, S., Schmieder, R.E.   +5 more
core   +1 more source

Vertebroplasty and the Placebo Response [PDF]

Radiology, 2011
Our interpretation of the evidence for vertebroplasty has distinctive implications for clinical practice and health policy.
Franklin G, Miller, David F, Kallmes, Rachelle, Buchbinder   +2 more
openaire   +2 more sources

An exploratory machine learning approach to identify placebo responders in pharmacological binge eating disorder trials

Clinical and Translational Science, 2022
Randomized, placebo‐controlled trials for binge eating disorder (BED) have revealed highly variable, and often marked, rates of short‐term placebo response.
Rahul K. Goyal, Shamir N. Kalaria, Susan L. McElroy, Mathangi Gopalakrishnan   +3 more
doaj   +1 more source

Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults. [PDF]

, 2019
It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status.
Breen, Elizabeth C, Eisenberger, Naomi I, Irwin, Michael R, Jevtic, Ivana, Moieni, Mona, Muscatell, Keely A   +5 more
core  

Steroids in pediatric eosinophilic esophagitis [PDF]

, 2014
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids.
Contreras, Emily M., Gupta, Sandeep K.
core   +1 more source

Genomic Effects Associated With Response to Placebo Treatment in a Randomized Trial of Irritable Bowel Syndrome

Frontiers in Pain Research, 2022
Background and Aims: Irritable bowel syndrome (IBS), a functional pain disorder of gut-brain interactions, is characterized by a high placebo response in randomized clinical trials (RCTs).
Rui-Sheng Wang, Rui-Sheng Wang, Anthony J. Lembo, Anthony J. Lembo, Ted J. Kaptchuk, Ted J. Kaptchuk, Vivian Cheng, Judy Nee, Judy Nee, Johanna Iturrino, Johanna Iturrino, Meenakshi Rao, Meenakshi Rao, Joseph Loscalzo, Joseph Loscalzo, Jocelyn A. Silvester, Jocelyn A. Silvester, Jocelyn A. Silvester, Jocelyn A. Silvester, Kathryn T. Hall, Kathryn T. Hall, Kathryn T. Hall   +21 more
doaj   +1 more source

Guideline on the use of onabotulinumtoxinA in chronic migraine. a consensus statement from the European Headache Federation [PDF]

, 2018
OnabotulinumtoxinA is being increasingly used in the management of chronic migraine (CM). Treatment with onabotulinumtoxinA poses challenges compared with traditional therapy with orally administered preventatives.
Ahmed, Fayyaz, Ashina, Messoud, Bendtsen, Lars, Hospital Universitari Vall d'Hebron, Martelletti, Paolo, Mitsikostas, Dimos, Pozo-Rosich, Patricia, Sacco, Simona, Universitat Autònoma de Barcelona   +8 more
core   +3 more sources

Ultra-overt therapy: a novel medical approach centered on patient consciousness

Frontiers in Integrative Neuroscience
Within the realms of human and artificial intelligence, the concepts of consciousness and comprehension are fundamental distinctions. In the clinical sphere, patient awareness regarding medication and its physiological processes plays a crucial role in ...
Kamran Shirbache, Amirreza Liaghat, Sanam Saeifar, Ahmadreza Nezameslami, Ali Shirbacheh, Hamid Nasri, Hamidreza Namazi   +6 more
doaj   +1 more source

Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis

BMC Musculoskeletal Disorders, 2018
Background Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients ...
Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal, Marc C. Hochberg   +8 more
doaj   +1 more source