Results 51 to 60 of about 8,509,826 (346)
Causal progress with imperfect placebo treatments and outcomes [PDF]
arXiv, 2023 In the quest to make defensible causal claims from observational data, it is sometimes possible to leverage information from "placebo treatments" and "placebo outcomes". Existing approaches employing such information focus largely on point identification and assume (i) "perfect placebos", meaning placebo treatments have precisely zero effect on the ...
arxiv
Projection-based two-sample inference for sparsely observed multivariate functional data [PDF]
, 2023 Modern longitudinal studies collect multiple outcomes as the primary endpoints to understand the complex dynamics of the diseases. Oftentimes, especially in clinical trials, the joint variations among the multidimensional responses play a significant role in assessing the differential characteristics between two or more groups, rather than drawing ...
arxiv +1 more source
Evidence Based Journals, 2018 It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews examined this issue and reached
T. Furukawa +8 more
semanticscholar +1 more source
Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia
American Journal of Hematology, Volume 98, Issue 2, Page 338-347, February 2023., 2023 Abstract Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include ...
Jorge J. Castillo +4 more
wiley +1 more source
World Psychiatry, 2017 More than fifteen years ago, it was noted that the failure rate of antidepressant clinical trials was high, and such negative outcomes were thought to be related to the increasing magnitude of placebo response.
Arif Khan +4 more
semanticscholar +1 more source
Ophthalmology and Therapy, 2023 Many candidate drugs for dry eye disease (DED) have been assessed over the years in pursuit of demonstrating efficacy in both signs and symptoms. However, patients with DED have very limited treatment options for management of both signs and symptoms of ...
Michela Montecchi-Palmer +5 more
doaj +1 more source
The Role of Placebo Samples in Observational Studies [PDF]
arXiv, 2022 In an observational study, it is common to leverage known null effect to detect bias. One such strategy is to set aside a placebo sample -- a subset of data immune from the hypothesized cause-and-effect relationship. Existence of an effect in the placebo sample raises concern of unmeasured confounding bias while absence of it corroborates the causal ...
arxiv
Health Psychology, 2017 Objective: Research on placebo/nocebo effects suggests that expectations can influence treatment outcomes, but placebo/nocebo effects are not always evident.
Lauren C. Howe, J. Goyer, A. Crum
semanticscholar +1 more source
The roles and applications of extracellular vesicles in cancer
Molecular Oncology, EarlyView.Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Does the rising placebo response impact antihypertensive clinical trial outcomes? An analysis of data from the Food and Drug Administration 1990-2016. [PDF]
PLoS ONE, 2018 Recent studies show that placebo response has grown significantly over time in clinical trials for antidepressants, ADHD medications, antiepileptics, and antidiabetics.
Arif Khan +3 more
doaj +1 more source