Results 61 to 70 of about 8,509,826 (346)
Assessing Vaccine Durability in Randomized Trials Following Placebo Crossover [PDF]
arXiv, 2021 Randomized vaccine trials are used to assess vaccine efficacy and to characterize the durability of vaccine induced protection. If efficacy is demonstrated, the treatment of placebo volunteers becomes an issue. For COVID-19 vaccine trials, there is broad consensus that placebo volunteers should be offered a vaccine once efficacy has been established ...
arxiv
Antidepressants and the Placebo Response
Epidemiology and Psychiatric Sciences, 2009 SUMMARYAims – To evaluate new generation antidepressants in relation to the placebo response. Methods – I review meta-analyses in which response to antidepressant medication and response to placebo were calculated. Results – All but one of these meta-analyses included unpublished as well as published trials.
openaire +3 more sources
Schizophrenia bulletin, 2016 Several meta-analyses have assessed the response of patients with schizophrenia with auditory verbal hallucinations (AVH) to treatment with repetitive transcranial magnetic stimulation (rTMS); however, the placebo response has never been explored ...
S. Dollfus +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression [PDF]
arXiv, 2021 The glutamatergic modulator ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant major depressive disorder (TRD). Although its mechanisms of action are not fully understood, changes in cortical excitation/inhibition (E/I) following ketamine administration are well documented in animal models and could ...
arxiv
Manipulating the Placebo Response in Experimental Pain by Altering Doctor’s Performance Style
Frontiers in Psychology, 2016 Background: Performance is paramount in traditional healing rituals. From a Western perspective, such performative behavior can be understood principally as inducing patients’ faith in the performer’s supernatural healing powers and effecting positive ...
E. Czerniak +6 more
semanticscholar +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
International Forum of Allergy &Rhinology, Volume 13, Issue 1, Page 31-41, January 2023., 2023 Abstract Background Sinus surgery removes inflamed tissue, restores airflow, and improves delivery of medication into surgically opened spaces. The exhalation delivery system with fluticasone (EDS‐FLU; XHANCE®) uses a novel delivery system to create closed‐palate, positive‐pressure, bidirectional mechanics that significantly alter the deposition of the
Randall A. Ow +6 more
wiley +1 more source
Clinical and Translational Science, 2022 Randomized, placebo‐controlled trials for binge eating disorder (BED) have revealed highly variable, and often marked, rates of short‐term placebo response.
Rahul K. Goyal +3 more
doaj +1 more source
Point and interval estimation of the target dose using weighted regression modelling [PDF]
arXiv, 2020 In a Phase II dose-finding study with a placebo control, a new drug with several dose levels is compared with a placebo to test for the effectiveness of the new drug. The main focus of such studies often lies in the characterization of the dose-response relationship followed by the estimation of a target dose that leads to a clinically relevant effect ...
arxiv