Results 61 to 70 of about 317,198 (215)

Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial

PAIN Reports, 2019
. Introduction:. Denervation of the lumbar zygapophyseal joints by medial branch radiofrequency neurotomy has shown some benefit in treating chronic low-back pain.
Damien Finniss, Michael Nicholas, Charles Brooker, Michael Cousins, Fabrizio Benedetti   +4 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

The relation of emotions to placebo responses [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
The hypothesis put forth is that expectations of treatment effects reduce negative emotions and thereby reduce symptoms, e.g. pain. Negative emotions increase pain, and it is hypothesized that placebos reduce pain by reducing negative emotions, i.e. feelings of nervousness, fear and anxiety.
Espen Bjørkedal, Peter Solvoll Lyby, Magne Arve Flaten, Per M. Aslaksen   +3 more
openaire   +3 more sources

A systematic review of sex differences in the placebo and the nocebo effect

Journal of Pain Research, 2017
Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Vambheim SM, Flaten MA
doaj  

Is placebo analgesia for heat pain a sensory effect? An exploratory study on minimizing the influence of response bias

Neurobiology of Pain, 2019
We explored the ongoing question of whether placebo analgesia alters afferent nociceptive processing in a novel paradigm designed to minimize the role of response bias in placebo measurement.
Laura K. Case, Claire M. Laubacher, Emily A. Richards, Matthew Grossman, Lauren Y. Atlas, Scott Parker, M. Catherine Bushnell   +6 more
doaj   +1 more source

Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping

Osteoarthritis and Cartilage Open
Objective: This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA.
Tommy Kok Annfeldt, Elisabeth Ginnerup-Nielsen, Eva Elisabeth Wæhrens, Lene Vase, Lars Erik Kristensen, Tanja Schjødt Jørgensen   +5 more
doaj   +1 more source

Placebo response in depression [PDF]

British Journal of Psychiatry, 2001
An unstated conclusion to Gavin Andrews' editorial ([2001][1]) is surely that placebo controlled trials are absolutely essential to our understanding of the true effects of antidepressants.
openaire   +2 more sources

Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trial

BMC Medical Research Methodology, 2009
Background Assumptions underlying placebo controlled trials include that the placebo effect impacts on all study arms equally, and that treatment effects are additional to the placebo effect.
Bone Kerry M, van Die M Diana, Burger Henry G, Teede Helena J   +3 more
doaj   +1 more source

Bronchial and cardiovascular responses to inhaled reproterol in asthmatics: a double‐blind placebo controlled dose‐response study. [PDF]

, 1985
P A Patchett, SM Patchett, P.S. Burge
openalex   +1 more source

Novel study designs to investigate the placebo response

BMC Medical Research Methodology, 2011
Background Investigating the size and mechanisms of the placebo response in clinical trials have relied on experimental procedures that simulate the double-blind randomized placebo-controlled design.
Klosterhalfen Sibylle, Enck Paul, Zipfel Stephan   +2 more
doaj   +1 more source