Results 61 to 70 of about 648,282 (342)

An exploratory machine learning approach to identify placebo responders in pharmacological binge eating disorder trials

Clinical and Translational Science, 2022
Randomized, placebo‐controlled trials for binge eating disorder (BED) have revealed highly variable, and often marked, rates of short‐term placebo response.
Rahul K. Goyal, Shamir N. Kalaria, Susan L. McElroy, Mathangi Gopalakrishnan   +3 more
doaj   +1 more source

Vertebroplasty and the Placebo Response [PDF]

Radiology, 2011
Our interpretation of the evidence for vertebroplasty has distinctive implications for clinical practice and health policy.
Franklin G, Miller, David F, Kallmes, Rachelle, Buchbinder   +2 more
openaire   +2 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Sex Differences in the Effect of Inflammation on Subjective Social Status: A Randomized Controlled Trial of Endotoxin in Healthy Young Adults. [PDF]

, 2019
It has been established that inflammation leads to a variety of changes in social experience, but one area of social experience that has been overlooked is subjective social status.
Breen, Elizabeth C, Eisenberger, Naomi I, Irwin, Michael R, Jevtic, Ivana, Moieni, Mona, Muscatell, Keely A   +5 more
core  

In situ anticaries efficacy of dentifrices with different formulations – A pooled analysis of results from three randomized clinical trials [PDF]

, 2018
Objectives Data generated from three similar in situ caries crossover studies presented the opportunity to conduct a pooled analysis to investigate how dentifrice formulations with different fluoride salts and combinations at concentrations of 1400 ...
Bosma, Mary Lynn, Butler, Andrew, Constantin, Paul, Creeth, Johnathan, Hara, Anderson T., Lippert, Frank, Newby, Evelyn, Zero, Domenick T.   +7 more
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study [PDF]

, 2015
Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients.
Bathon, Joan M., Beaulieu, Andre D., Carlson, Timothy H., Codding, Christine E., Delles, Christian, Giles, Jon T., Lee, Janet S., McInnes, Iain B., Salmon, Jane E., Sattar, Naveed, Thompson, Liz   +10 more
core   +1 more source

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis

BMC Musculoskeletal Disorders, 2018
Background Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients ...
Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal, Marc C. Hochberg   +8 more
doaj   +1 more source

Genomic Effects Associated With Response to Placebo Treatment in a Randomized Trial of Irritable Bowel Syndrome

Frontiers in Pain Research, 2022
Background and Aims: Irritable bowel syndrome (IBS), a functional pain disorder of gut-brain interactions, is characterized by a high placebo response in randomized clinical trials (RCTs).
Rui-Sheng Wang, Rui-Sheng Wang, Anthony J. Lembo, Anthony J. Lembo, Ted J. Kaptchuk, Ted J. Kaptchuk, Vivian Cheng, Judy Nee, Judy Nee, Johanna Iturrino, Johanna Iturrino, Meenakshi Rao, Meenakshi Rao, Joseph Loscalzo, Joseph Loscalzo, Jocelyn A. Silvester, Jocelyn A. Silvester, Jocelyn A. Silvester, Jocelyn A. Silvester, Kathryn T. Hall, Kathryn T. Hall, Kathryn T. Hall   +21 more
doaj   +1 more source