Results 61 to 70 of about 14,257 (219)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

The human placental sexome differs between trophoblast epithelium and villous vessel endothelium. [PDF]

PLoS ONE, 2013
Molecular mechanisms underlying sexual dimorphism in mammals, fetal sex influences on intrauterine development, and the sex-biased susceptibility for selected diseases in adulthood are novel areas of current research.
Silvija Cvitic, Mark S Longtine, Hubert Hackl, Karin Wagner, Michael D Nelson, Gernot Desoye, Ursula Hiden   +6 more
doaj   +1 more source

Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta‐Heart Axis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Concurrent development of the placenta and heart during early gestation suggests a shared biological basis for the co‐occurrence of abnormal placentation and congenital heart disease (CHD). This study investigated the association between placental vascular pathology and CHD type.
Natalie Lanners, Sarah U. Morton, Katherine Le, Steffy Blanco, Sara Mansoorshahi, Chrystalle Katte Carreon, Christina Ronai, Louise Wilkins‐Haug, Vidhya Annavajjhala, Jacqueline G. Parchem, Tina O. Findley   +10 more
wiley   +1 more source

Three-dimensional morphological analysis of placental terminal villi.

, 2019
Transport of nutrients and waste between the maternal and fetal circulations during pregnancy takes place at the final branches of the placental villous trees. Therefore, and unsurprisingly, pregnancy complications have been related to the maldevelopment

core   +1 more source

Role of ACE I/D polymorphism in pathological assessment of preeclampsia in Pakistan

Molecular Genetics & Genomic Medicine, 2019
Background Preeclampsia (PE) is a pregnancy‐related hypertensive disorder, which may stem from impair placentation. Renin‐angiotensin system is one of the mediators of decidualization and trophoblastic proliferation.
Ghazala Shaheen, Sabahat Sajid, Suhail Razak, Saeeda Batool Mazhar, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan   +7 more
doaj   +1 more source

Localization of matrix metalloproteinases in the placenta of cows with complicated pregnancy by placental insufficiency [PDF]

BIO Web of Conferences
The placenta of 8 cows with physiological (PP) and placental insufficiency pregnancy (FPI) served as the material for the study. Analysis of the content of glycosaminoglycans (GAG) in the tissue of the uterine part of the placenta in cows with FPI ...
Avdeenko V.S., Safronov D.I., Akhmadov V.T.   +2 more
doaj   +1 more source

Prenatal Genetic Testing for Beckwith‐Wiedemann Syndrome: Considerations, Challenges and Observations (A Real‐World Study)

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal genetic testing for imprinting disorders is rarely requested with the exception of Beckwith‐Wiedemann syndrome (BWS) which is associated with specific ultrasound findings (e.g., placental mesenchymal dysplasia, omphalocele). However, genetic testing for BWS is challenging as aberrant DNA methylation has to be addressed which
Melissa Connolly, Louise McClelland, Pierpaola Tannorella, Tanja Richter, Ester Mainini, Andreas Dufke, Annette Lischka, Matthias Begemann, Katja Eggermann, Thomas Eggermann, Silvia Russo   +10 more
wiley   +1 more source

MORPHOMETRIC PARAMETERS OF PLACENTAL CHORIONIC VILLI IN LABOR AFTER 40 WEEKS

Неонатологія, хірургія та перинатальна медицина
The placenta is the main organ that ensures the vital activity of the fetus during pregnancy. Studying the morphometric characteristics of chorionic villi allows us to better understand the changes that occur in the placenta in late pregnancy.
О. Козар
doaj   +1 more source

Placental basal plate with attached myofibers and adverse pregnancy outcomes: A systematic scoping review

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
The presence of basal plate myometrial fibers was associated with higher rates of placenta‐related pregnancy disorders and abnormal placental attachment in subsequent pregnancies, but heterogeneity in the data was found due to variable inclusion criteria, sampling methods, and reported outcomes.
Eric Jauniaux, Helena C. Bartels, Paul Downey, Francesco D'Antonio   +3 more
wiley   +1 more source

Placental Hypoxia Developed During Preeclampsia Induces Telocytes Apoptosis in Chorionic Villi Affecting The Maternal-Fetus Metabolic Exchange [PDF]

, 2016
Telocytes (TC) are a new type of stromal cells initially found and studied in digestive and extra-digestive organs. These cells have a small cell body with 2 to 5 thin and extremely long cytoplasmic prolongations named telopodes. In recent years, TC have
Rodrigo Salinas, Ramón, Bosco Becerra, Cleofina, Díaz Guerra, Eugenia, Gutiérrez Rojas, Rodrigo, Barja Yáñez, Pilar, Parra Cordero, Mauro, González Montero, Jaime   +6 more
core   +1 more source