Results 121 to 130 of about 6,450,626 (234)

Plant-derived extracellular vesicles in skin and bone tissue engineering: current status, challenges, and future perspectives

Frontiers in Bioengineering and Biotechnology
Plant-derived extracellular vesicles (PDEVs) are bioactive nanoscale vesicles secreted by plant cells, which have recently gained attention as promising therapeutic agents in tissue engineering owing to their low immunogenicity, inherent biological ...
Chenyang Lu, Dipeng Li, Dipeng Li, Wenxin Gao, Xiaoxian Sun, Yan Zhang, Yunfei Yu, Chenghao Fei, Peina Zhou, Mao Wu   +9 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Extracellular Vesicles as a Potential Tool in Cancer Diagnosis and Therapy

Biomedicines
Cancer remains one of the leading causes of morbidity and mortality worldwide, with lung, breast, and colorectal cancers among the most prevalent and lethal malignancies.
Giovanni Citelli, Simone Peria, Sabina Di Matteo, Roberto Sirica, Federica Palmiero, Daniela Rita Vantaggiato, Rita Paola Debri, Raffaele Conte, Gianfranco Peluso   +8 more
doaj   +1 more source

Recommendations for Studying In Situ Extracellular Vesicles From Solid Tissue

Solid tissue-derived extracellular vesicles (ST-EVs) are extracellular vesicles (EVs) separated directly from solid tissues of both vertebrates and invertebrates.
Huang, Yiyao, Hendrix, An, Paolini, Lucia, Levy, Efrat, Crescitelli, Rossella, Hill, Andrew F., Puig, Berta, Vella, Laura J., Hurwitz, Stephanie N., Ikezu, Tsuneya   +9 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

, 2019
Extracellular vesicles (EVs), including exosomes and microvesicles, are secreted from all cells, and convey messages between cells in health and disease. However, the diversity of EV subpopulations is only beginning to be explored.
Roger Olofsson Bagge, Lötvall, Jan,, Belgrano, Valerio,, Ochiya, T., Takahiro Ochiya, Crescitelli, Rossella,, Cvjetkovic, Aleksander,, Sundfeldt, Karin,, Jang, Su Chul,, Kalluri, R., Su Chul Jang, Olofsson Bagge, Roger,, Aleksander Cvjetkovic, Karin Sundfeldt, Jan Lötvall, Raghu Kalluri, Rossella Crescitelli, Valerio Belgrano   +17 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Phytochemical-Primed Extracellular Vesicles and Plant-Derived Exosome-Like Nanoparticles as Endogenous Nanomedicine Platforms

International Journal of Nanomedicine
Yaqin Hou,1,* Liang Wu,2,* Jing Wang,1 Bin Han,1 Xiaolei Yu31School of Pharmacy, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China; 2Nanchong Key ...
Hou Y, Wu L, Wang J, Han B, Yu X
doaj  

Plant-derived extracellular vesicles in stress mitigation and crop improvement

Discover Plants
Plant-derived extracellular vesicles (PDEVs) have emerged as key mediators of plant stress biology, transforming our understanding of how plants respond to and tolerate adverse environmental conditions. These nano-sized vesicles act as specific shuttles,
Harsha Sreeraj, K. S. Tamilselvi, Nirmal Kumar Ramasamy   +2 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source