Results 101 to 110 of about 6,450,626 (234)

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Extracellular membrane vesicles from keratinocytes [PDF]

, 2017
This project was the first to simultaneously study the three different types of extracellular membrane vesicles (EVs) released by skin cells in order to reveal the differences in their bioactive molecular cargo.
Than, Thi Trang Uyen
core   +1 more source

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source

Isolating Astrocyte-Derived Extracellular Vesicles From Urine [PDF]

Xin-hui Xie,1,* Mian-mian Chen,1,* Shu-xian Xu,1 Junhua Mei,1,2 Qing Yang,2 Chao Wang,1 Honggang Lyu,1 Qian Gong,1 Zhongchun Liu1,3 1Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China ...
Liu Z, Xu SX, Gong Q, Wang C, Mei J, Lyu H, Chen MM, Yang Q, Xie XH   +8 more
core  

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Malus domestica fruit-derived vesicles extract protect against upstream cellular hallmarks of vascular inflammation and epithelial barrier dysfunction

Frontiers in Pharmacology
BackgroundDysbiosis impairs the intestinal barrier, facilitating the systemic translocation of inflammatory molecules into the bloodstream and ultimately contributing to cardiovascular disease.
Ilenia Pia Cappucci, Laura Basile, Lucia Sileo, Maria Pia Cavaleri, Luna Ardondi, Ilaria Vitali, Marta Degasperi, Jasmine Chini, Luca Lovatti, Leo Massari, Sonia Missiroli, Paolo Pinton, Barbara Zavan, Letizia Ferroni   +13 more
doaj   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

Plant-Derived Nanovesicles: Resolving Conceptual Confusion, Overcoming Isolation Challenges, and Advancing Translational Potential

International Journal of Nanomedicine
Zhaoyu Zhang,1,2,* Guangyang Chen,1,3,* Kaiyuan Zheng,4,* Meifang Lin,1,2 Dali Zheng,1 Youguang Lu,1,2 Li Huang,1,3 Xiaohang Chen,1,2 Ruihuan Gan1,2 1Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology ...
Zhang Z, Chen G, Zheng K, Lin M, Zheng D, Lu Y, Huang L, Chen X, Gan R   +8 more
doaj  

Beyond basic characterization and omics : Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases.
Oxvig, Claus,, Kari, Otto K., Kari, Otto, Masood Kamali‐Moghaddam, Federico, Antonio,, Siljander, Pia R.M., Rikke Halse Østergaard, Kamali-Moghaddam, Masood,, Laitinen, Saara, Eble, Johannes A., Kjaer-Sorensen, Kasper, Hayashi, Yuya, Kasper Kjaer‐Sorensen, Joseph Ndika, Palviainen, Mari, Greco, Dario,, Juan M. Falcon‐Perez, Mari Palviainen, Laitinen, Saara,, Saara Laitinen, Palviainen, Mari,, Claus Oxvig, Aransay, Ana M.,, Federico, Antonio, Maaninka, Katariina, Ana M. Aransay, Falcon-Perez, Juan M., Katariina Maaninka, Pia R.‐M. Siljander, Kamali-Moghaddam, Masood, Aransay, Ana M., Eble, Johannes A.,, Halse Østergaard, Rikke,, Falcon-Perez, Juan M.,, Eble, Johannes, Butt, Umar, Butt, Umar,, Østergaard, Rikke Halse, Greco, Dario, Umar Butt, Oxvig, Claus, Ndika, Joseph,, Kjaer-Sorensen, Kasper,, Johannes A. Eble, Dario Greco, Ndika, Joseph, Johanna Puutio, Puutio, Johanna, Puutio, Johanna,, Ostergaard, Rikke, Yuya Hayashi, Kari, Otto K.,, Otto K. Kari, Antonio Federico, Siljander, Pia, Aransay, Ana, Hayashi, Yuya,, Maaninka, Katariina,, Halse Østergaard, Rikke, Siljander, Pia R. -M., Siljander, Pia R. -M.,   +60 more
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source