Results 111 to 120 of about 6,450,626 (234)

Dosing of plant-derived extracellular vesicles in traditional Chinese medicine: current status, root causes, and standardization pathways

Frontiers in Pharmacology
Extracellular vesicles derived from Traditional Chinese Medicine represent a growing research Frontier. However, no consensus exists regarding the definition, quantification, and reporting of administered doses.
Mingxin Guo
doaj   +1 more source

Mechanisms and Translational Potential of Plant-Derived Extracellular Vesicles in Cardiovascular Disease

Cells
Cardiovascular diseases remain a major global health burden. Plant-derived extracellular vesicles (PDEVs) are increasingly being investigated as potential therapeutic and drug-delivery platforms for cardiovascular disease. PDEVs are natural nanovesicles carrying bioactive lipids, proteins, nucleic acids, and phytochemicals.
Songyan Tie, Huifang Kuang, Hang Xu, Qian Guo, Jie Li, Lingli Chen   +5 more
openaire   +3 more sources

A Noninvasive Approach to Study Localized Forces in 3D Epithelia

Advanced Materials, EarlyView.
Epithelial morphogenesis depends on dynamic mechanical coupling between adhesion complexes and the cytoskeleton, yet its regulation in polarized 3D tissues remains elusive. We developed a noninvasive strategy using cell‐like elastic microbeads to quantify local forces in intact epithelia.
Niels Gouirand, Muhamet Ibrahimi, Claire Valotteau, Brice Lecouffe, André Le Bivic, Dominique Massey‐Harroche, Felix Rico, Matthias Merkel, Delphine Delacour, Elsa Bazellières   +9 more
wiley   +1 more source

Past, Present, and Future of Plant-Derived Extracellular Vesicles in Biomedical Applications

Pharmaceuticals
Plant-derived extracellular vesicles (PDEVs) have emerged as promising natural nanocarriers for biomedical applications owing to their distinctive ability to facilitate intercellular communication and transport bioactive molecules. In this review, we employ bibliometric analysis to identify research hotspots and trends, providing a comprehensive ...
Yilixiati Wusiman, Xiaoxiao Qiu, Nazhakaiti Yusufujiang, Yipaerguli Paerhati, Alifeiye Aikebaier, Dilihuma Dilimulati, Alhar Baishan, Wenting Zhou   +7 more
openaire   +3 more sources

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Metastatic colon cancer extracellular vesicles spread malignant properties in tumour microenvironment affecting the behaviour of both tumour and endothelial cells

, 2016
Metastatic colon cancer extracellular vesicles spread malignant properties in tumour microenvironment affecting the behaviour of both tumour and endothelial ...
Odessa Schillaci, Simona Taverna, Riccardo Alessandro, Simona Fontana, Francesca Monteleone, Dolores Di Vizio, Valentina Minciacchi   +6 more
core  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source