Results 51 to 60 of about 6,450,626 (234)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Protocol for isolating plant-derived extracellular vesicles

STAR Protocols
Plant-derived extracellular vesicles (PEVs) are nanosized, lipid bilayer-enclosed vesicles secreted by plant cells into the extracellular space, playing critical roles in intercellular communication. Here, we present a comprehensive and reproducible protocol for isolating PEVs from diverse plant species.
Chen, Yunyi, Xu, Le, Yu, Yuanyuan, Xu, Zhifeng, Xiao, Songhua, Mai, Hongcheng   +5 more
openaire   +2 more sources

Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Journal of Nanobiotechnology, 2023
Abstract Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as ...
Zhijie Xu, Yuzhen Xu, Kui Zhang, Yuanhong Liu, Qiuju Liang, Abhimanyu Thakur, Wei Liu, Yuanliang Yan   +7 more
openaire   +3 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Exogenous Extracellular Vesicles as Emerging Platforms in Translational Medicine

BIO Integration
Extracellular vesicles (EVs) are nanoscale, membrane-bound carriers that are naturally secreted by cells and capable of transporting proteins, lipids, and nucleic acids across biological barriers.
Muran Bai, Zhongshi Li, Tianren Shi, Xiangling Li, Jia Li, Jian Ma, Lei Huang, Zhijin Fan   +7 more
doaj   +1 more source

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

Molecules, 2021
In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products contain a
Željka Peršurić, Sandra Kraljević Pavelić   +1 more
doaj   +1 more source

Quantitative proteomic analysis of trypsin‐treated extracellular vesicles to identify the real‐vesicular proteins

, 2020
Extracellular vesicles (EVs) are nano-sized vesicles surrounded by a lipid bilayer and released into the extracellular milieu by most of cells. Although various EV isolation methods have been established, most of the current methods isolate EVs with ...
Seon‐Min Park, Go, Gyeongyun, Choi, Dongsic, Jaewook Lee, Di Vizio, Dolores, Dae‐Kyum Kim, Gyeongyun Go, Dolores Di Vizio, Yong Song Gho, Park, Seon-Min, Gho, Yong Song, Dongsic Choi, Lee, Jaewook, Kim, Dae-Kyum   +13 more
core   +1 more source

Lipidome profiling of human and equine neutrophil-derived extracellular vesicles and their potential contribution to the ensemble of synovial fluid-derived extracellular vesicles during joint inflammation

, 2023
The molecular signature of cell-derived extracellular vesicles (EVs) in synovial fluid (SF) can provide information about cells and molecular processes involved in joint disorders.
Chris H.A. van de Lest (Utrecht University), Laura Varela (Utrecht University)   +1 more
core   +1 more source

Plant-derived extracellular vesicles for drug delivery: current and future

Regenerative Biomaterials
Abstract Plant-derived extracellular vesicles (PDEVs) have attracted considerable attention as natural drug delivery vehicles owing to their low immunogenicity, excellent biocompatibility, cross-kingdom delivery capability and intrinsic targeting properties.
Xu, Fengdan, Liu, Yuling, Zhang, Qiling, Tang, Ruying, Li, Hui, Yang, Hongjun, Lin, Longfei   +6 more
openaire   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source