Results 71 to 80 of about 6,450,626 (234)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Blueberry-derived extracellular vesicles as a novel nanobioplatform for immunotherapy

, 2022
This research developed multifunctional nano-bioplatform for drug delivery using blueberry-derived extracellular nanovesicles, followed by the investigation of potential 'universal' biomarkers for plant-derived extracellular vesicles.
Tuong Ngoc-Gia Nguyen (15800969)
core  

Characterization of and isolation methods for plant leaf nanovesicles and small extracellular vesicles

, 2020
Mammalian small extracellular vesicles (sEVs) can deliver diverse molecules to target cells. However, they are difficult to obtain in large quantities and can activate host immune responses.
Koo, Yeonjong, Hwang, Elaine, Tang, E. Chia-Cheng, Braam, Janet, de Val, Natalia, Sood, Anil K., Khant, Htet, Wei, Haichao, Dasari, Santosh K., Liu, Yuan, Court, Karem, Dai, Yanwan, Wen, Yunfei, Chowdhury, Mamur, Yang, An, Wu, Sherry, Li, Yang, Osman, Samantha R., Nguyen, Michael, Chehab, E. Wassim   +19 more
core   +1 more source

Plant-derived extracellular vesicles as tools and targets for inflammatory diseases

Journal of Nanobiotechnology
Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammatory drugs and biologics, often provide incomplete relief and cause significant side effects, creating an urgent need for safer, more effective ...
Tan, Fengyu, Liu, Wangrui, Li, Tongfei, Li, Liugen, Chen, Zhiqiang, Thakur, Abhimanyu, Zhang, Kui, Zhan, Cheng, Tang, Hailin, Yan, Yuanliang, Li, Yong, Zhu, Xudong, Xu, Zhijie   +12 more
openaire   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Biodistribution, Uptake and Effects Caused by Cancer-derived Extracellular Vesicles [PDF]

, 2015
Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids.
Kalniņa, Zane, Zane Kalniņa, Zane Kalniņa, Cristina Bajo Santos, Aija Line, Bajo Santos, Cristina, Line, Aija, Lilite Sadovska, Sadovska, Lilite   +8 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Extracellular Vesicles Derived from Natural Biological Resources and Their Potential to Facilitate Skin Regeneration and Rejuvenation

Pharmaceutics
The skin, the largest organ in the human body, serves as a crucial barrier against external stimuli. With the acceleration of social industrialization and the worsening of global climate change, the risk of physical, chemical and biological damage to the
Zhuoyue Yang, Shijun Li, Hangyu Zhang, Zhigang Sui, Na Li   +4 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source