Results 61 to 70 of about 6,450,626 (234)

Plant-Derived Extracellular Vesicles as a Novel Frontier in Cancer Therapeutics

Nanomaterials
Recent advancements in nanomedicine and biotechnology have unveiled the remarkable potential of plant-derived extracellular vesicles (PDEVs) as a novel and promising approach for cancer treatment. These naturally occurring nanoscale particles exhibit exceptional biocompatibility, targeted delivery capabilities, and the capacity to load therapeutic ...
Lishan Cui, Giordano Perini, Valentina Palmieri, Marco De Spirito, Massimiliano Papi   +4 more
openaire   +4 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Isolation and characterizataion of prostate-derived extracellular vesicles as a liquid biopsy strategy in cancer diagnosis

, 2022
S.385Introduction: In the past years, extracellular vesicles (EVs) have attracted considerable interest due to their ability to provide valuable diagnostic information from liquid biopsies.
Kuhlmeier, Dirk, Allelein, Susann, Heitor Lopes, Ana Leonor, Medina-Perez, Paula, Rau, Sabrina, Kölsch, Andreas   +5 more
core   +1 more source

Extracellular vesicles in reproductive medicine: from “animal-led” to “plant-enabled”

Frontiers in Cell and Developmental Biology
Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication in reproductive medicine, demonstrating considerable potential for both understanding and treating reproductive disorders. By precisely regulating key processes
Keying Pan, Wenhan Ju, Yue Wang, Qianwen Zhang, Ruyi Wang, Xingyue Jiang, Shuai Zhao   +6 more
doaj   +1 more source

Isolation of Extracellular Vesicles from Stem Cells

, 2017
Transplanted induced pluripotent stem cells (IPSC) and embryonic stem cells (ESC) exhibit enhanced survival in ischemic tissues and promote survival of neighboring cells via paracrine effects.
Liu, Yutao, Yutao Liu, Kim, Il-Man, Neal L. Weintraub, Weintraub, Neal L., Chengwei Ju, Tang, Yaoliang, Genshan Ma, Il-man Kim, Yaoliang Tang, Ju, Chengwei, Hong Yu, Yongjun Li, Li, Yongjun, Zixin Chen, Yu, Hong, Yan Shen, Chen, Zixin, Shen, Yan, Ma, Genshan   +19 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Link between organic nanovescicles from vegetable kingdom and human cell physiology: intracellular calcium signalling

Journal of Nanobiotechnology
Background Plant-derived nanovesicles (PDNVs) are a novelty in medical and agrifood environments, with several studies exploring their functions and potential applications. Among fruits, apples (sp.
Martina Trentini, Ilaria Zanolla, Elena Tiengo, Federica Zanotti, Eduardo Sommella, Fabrizio Merciai, Pietro Campiglia, Danilo Licastro, Margherita Degasperi, Luca Lovatti, Massimo Bonora, Alberto Danese, Paolo Pinton, Barbara Zavan   +13 more
doaj   +1 more source

Pollen-derived extracellular vesicles promotes allergic airway inflammation

Frontiers in Immunology
BackgroundAsthma remains a global health burden, affecting over 300 million individuals worldwide, with its pathogenesis involving complex interactions between genetic predisposition and environmental allergens.
Tengze Shang, Junda Li, Yi Ru, Kai Guan
doaj   +1 more source

Development of Plant-derived Extracellular Vesicle-based Therapeutic Systems

YAKUGAKU ZASSHI
Plants have long supported human life as medicines and as sources of oxygen and food. Plant resources have played central roles in healthcare including traditional remedies and modern drugs such as aspirin. Recently, attention has shifted beyond small molecules to include higher-order biological structures such as extracellular vesicles (EVs).
Makiya, Nishikawa, Kosuke, Kusamori, Shoko, Itakura   +2 more
openaire   +2 more sources